Tolerance to Tick-Borne Diseases in Sheep: Highlights of a Twenty-Year Experience in a Mediterranean Environment

Pieragostini, E.; Ciani, Elena; Rubino, Giuseppe; Petazzi, Ferruccio

doi:10.5772/23309

Cited by 6 publications

(9 citation statements)

References 32 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Once all the seven independent variables were entered, the three groups were shown to be significantly differentiated (P < 0.0001, data not shown), thus confirming the previous results obtained by the univariate analysis which evidenced the different behaviour of the three breeds both in health conditions and in coping with anaplasmosis [8]. The separation of the three breeds was also visually appreciable from the scatter plot of the coefficients for the two discriminant functions (Figure 1).…”

Section: Resultssupporting

confidence: 86%

“…After inoculation with Anaplasma ovis , all the animals developed the disease but symptoms and haematological and clinical parameters varied in terms of severity and duration and none died [ 8 ].…”

Section: Resultsmentioning

confidence: 99%

“…On the whole, eleven clinical as well as haematological parameters (Table 2 ) were monitored at different temporal resolutions on the same subjects before and after the infection, resulting in a data set of 435 observations. For further details on the experimental design see Pieragostini et al [ 8 ].…”

Section: Methodsmentioning

confidence: 99%

“…Based on the above considerations, a study was carried out [ 8 ] to evaluate the response of sheep breeds native both from Southern Italy (Comisana and Altamurana) and Northern Europe (Suffolk) through an experimental infection with Anaplasma ovis , an obligate intraerythrocytic Rickettsia, the most prevalent sheep tick-borne pathogen (TBP) in Apulia (Southern Italy) [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Looking for prognosticators in ovine anaplasmosis: discriminant analysis of clinical and haematological parameters in lambs belonging to differently susceptible breeds experimentally infected with Anaplasma ovis

et al. 2013

Self Cite

View full text Add to dashboard Cite

BackgroundA study was carried out to evaluate the response of different native sheep breeds to experimental infection with Anaplasma ovis, the most prevalent sheep tick-borne pathogen in Apulia (Southern Italy). Thirty-four lambs belonging to a Northern European breed (Suffolk) and two Southern Italian breeds (Comisana and Altamurana) were infected. Eleven clinical as well as haematological parameters were monitored at different temporal resolutions on the same subjects before and after the infection, resulting in a data set of 435 observations. The present work, aiming to further the research, presents the results of a multivariate analysis carried out to identify which parameters out of the eleven considered are the most reliable parameters to be considered as markers of the disease phenotype as well as prognosticators of practical clinical importance.ResultsData were analysed by discriminant analysis. Out of the eleven considered variables (red blood cells, packed cell volume, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin content, haemoglobin concentration, white blood cells, neutrophils, leukocytes, platelets, rectal temperature), only seven were included in the step-wise model since significantly increasing the Mahlanobis distance between the two closest groups. Both discriminant functions resulted to be highly significant (P < 0.0001) and the percentage of variation accounted for by the first discriminant function was 63.6% of the variance in the grouping variable.ConclusionsTaken together, the observed results stress the marked differentiation among the three breeds in terms of physio-pathological phenotypes indicating packed cell volume and red blood cell count as the most informative parameters in the routine clinical practice for A. ovis infection in sheep.

show abstract

Section: Resultssupporting

confidence: 86%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Looking for prognosticators in ovine anaplasmosis: discriminant analysis of clinical and haematological parameters in lambs belonging to differently susceptible breeds experimentally infected with Anaplasma ovis

et al. 2013

Self Cite

View full text Add to dashboard Cite

show abstract

“…The previously undocumented introgression event detected here further aggravates the threatened status of this breed, known for its unusual hemoglobin polymorphism and tolerance to tickborne diseases (Pieragostini et al . ), and stresses the need for urgent and more effective conservation efforts.…”

Section: Discussionmentioning

confidence: 99%

Genome‐wide analysis of Italian sheep diversity reveals a strong geographic pattern and cryptic relationships between breeds

et al. 2013

View full text Add to dashboard Cite

Italy counts several sheep breeds, arisen over centuries as a consequence of ancient and recent genetic and demographic events. To finely reconstruct genetic structure and relationships between Italian sheep, 496 subjects from 19 breeds were typed at 50K single nucleotide polymorphism loci. A subset of foreign breeds from the Sheep HapMap dataset was also included in the analyses. Genetic distances (as visualized either in a network or in a multidimensional scaling analysis of identical by state distances) closely reflected geographic proximity between breeds, with a clear north-south gradient, likely because of high levels of past gene flow and admixture all along the peninsula. Sardinian breeds diverged more from other breeds, a probable consequence of the combined effect of ancient sporadic introgression of feral mouflon and long-lasting genetic isolation from continental sheep populations. The study allowed the detection of previously undocumented episodes of recent introgression (Delle Langhe into the endangered Altamurana breed) as well as signatures of known, or claimed, historical introgression (Merino into Sopravissana and Gentile di Puglia; Bergamasca into Fabrianese, Appenninica and, to a lesser extent, Leccese). Arguments that would question, from a genomic point of view, the current breed classification of Bergamasca and Biellese into two separate breeds are presented. Finally, a role for traditional transhumance practices in shaping the genetic makeup of Alpine sheep breeds is proposed. The study represents the first exhaustive analysis of Italian sheep diversity in an European context, and it bridges the gap in the previous HapMap panel between Western Mediterranean and Swiss breeds.

show abstract

Haemoparasitism of Goats and Sheep

Stuen

2017

Sustainable Goat Production in Adverse Environments: Volume I

View full text Add to dashboard Cite

Tolerance to Tick-Borne Diseases in Sheep: Highlights of a Twenty-Year Experience in a Mediterranean Environment

Cited by 6 publications

References 32 publications

Looking for prognosticators in ovine anaplasmosis: discriminant analysis of clinical and haematological parameters in lambs belonging to differently susceptible breeds experimentally infected with Anaplasma ovis

Looking for prognosticators in ovine anaplasmosis: discriminant analysis of clinical and haematological parameters in lambs belonging to differently susceptible breeds experimentally infected with Anaplasma ovis

Genome‐wide analysis of Italian sheep diversity reveals a strong geographic pattern and cryptic relationships between breeds

Haemoparasitism of Goats and Sheep

Contact Info

Product

Resources

About