Tolerance to Plant Disease

Schafer, J. F.

doi:10.1146/annurev.py.09.090171.001315

Cited by 213 publications

(153 citation statements)

References 17 publications

Supporting

Mentioning

132

Contrasting

Unclassified

Order By: Relevance

“…An historical perspective of disease tolerance: Disease tolerance was first recognized as a plant defense strategy against infection 88,89 , with its original description dating back to as early as the end of the XIX century 90 . The concept was refined by mid XX century, as the ability to sustain infection without a concomitant reduction in host fitness 89 .…”

Section: Boxmentioning

confidence: 99%

Section: Boxmentioning

confidence: 99%

“…The concept was refined by mid XX century, as the ability to sustain infection without a concomitant reduction in host fitness 89 . These studies posit that disease tolerance does not rely on reducing host pathogen load for preservation of health 88 but instead acts via mechanisms that limit parenchyma damage 89 . While the concept of disease tolerance was rapidly expanded to different types of infection in plants 89 , it took over a century to extrapolate this notion beyond the plant literature.…”

Section: Boxmentioning

confidence: 99%

“…These studies posit that disease tolerance does not rely on reducing host pathogen load for preservation of health 88 but instead acts via mechanisms that limit parenchyma damage 89 . While the concept of disease tolerance was rapidly expanded to different types of infection in plants 89 , it took over a century to extrapolate this notion beyond the plant literature. This was achieved by a series of studies on the immune response of Drosophila melanogaster to infection, which revealed that loss of function mutations in genes encoding inflammatory cytokines, e.g.…”

Section: Boxmentioning

confidence: 99%

See 3 more Smart Citations

Tissue damage control in disease tolerance

Soares

Gozzelino

Weis

2014

Trends in Immunology

154

174

View full text Add to dashboard Cite

The deposited article is a prost-print version.This publication hasn't any creative commons license associated.This deposit is composed by the main article, and it hasn't any supplementary materials associated.Immune-driven resistance mechanisms are the prevailing host defense strategy against infection. By contrast, disease tolerance mechanisms limit disease severity by preventing tissue damage or ameliorating tissue function without interfering with pathogen load. We propose here that tissue damage control underlies many of the protective effects of disease tolerance. We explore the mechanisms of cellular adaptation that underlie tissue damage control in response to infection as well as sterile inflammation, integrating both stress and damage responses. Finally, we discuss the potential impact of targeting these mechanisms in the treatment of disease.Fundação para a Ciência e Tecnologia grants: (PTDC/SAU-TOX/116627/2010, HMSP-ICT/0022/2010, SFRH/BPD/44256/2008); European Commission 7th Framework grant: (ERC-2011-AdG. 294709-DAMAGECONTROL); Deutsche Forschungsgemeinschaft grant: (DFG WE 4971/3-1).info:eu-repo/semantics/publishedVersio

show abstract

Section: Boxmentioning

confidence: 99%

Section: Boxmentioning

confidence: 99%

Section: Boxmentioning

confidence: 99%

Section: Boxmentioning

confidence: 99%

See 2 more Smart Citations

Tissue damage control in disease tolerance

Soares

Gozzelino

Weis

2014

Trends in Immunology

154

174

View full text Add to dashboard Cite

show abstract

“…This notion has been challenged over the past years by the (re)discovery of disease tolerance 5,6 . This evolutionarily conserved host defense strategy, which was first described in plants 7,8 , is fully operational in flies 9,10 and mammals, including rodents 11,12 and humans 13 , where it preserves host homeostasis in response to viral 14,15 , bacterial [15][16][17][18] , fungal 19 and protozoan 11,13,20,21 infections. In contrast to resistance to infection, disease tolerance does not exert a direct negative effect on these pathogens 6 .…”

Section: Introductionmentioning

confidence: 99%

Disease tolerance and immunity in host protection against infection

2017

View full text Add to dashboard Cite

The immune system has most likely evolved to limit the negative impact exerted by pathogens on host homeostasis. This defense strategy relies on the concerted action of innate and adaptive components of the immune system, which sense and target pathogens for containment, destruction or expulsion. Resistance to infection refers to these immune functions, which reduce the pathogen load of an infected host as the means to preserve homeostasis. Immune-driven resistance to infection is coupled to an additional, and arguably as important, defense strategy that limits the extent of dysfunction imposed to host parenchyma tissues during infection, without exerting a direct negative impact on pathogens.This defense strategy, called disease tolerance, relies on tissue damage control mechanisms that prevent the deleterious effects of pathogens, while uncoupling immunedriven resistance mechanisms from immunopathology and disease. Here we provide a unifying view of resistance and disease tolerance within the framework of immunity to infection.

show abstract

Crop Tolerance of Foliar Pathogens: Possible Mechanisms and Potential for Exploitation

Bingham¹,

Newton²

2009

Disease Control in Crops

View full text Add to dashboard Cite

Tolerance to Plant Disease

Cited by 213 publications

References 17 publications

Tissue damage control in disease tolerance

Tissue damage control in disease tolerance

Disease tolerance and immunity in host protection against infection

Crop Tolerance of Foliar Pathogens: Possible Mechanisms and Potential for Exploitation

Contact Info

Product

Resources

About