Tolerance to Donor-Type Skin in the Recipient of a Bone Marrow Allograft: Treatment of Skin Ulcers in Chronic Graft-Versus-Host Disease With Skin Grafts From the Bone Marrow Donor

Hy, Knobler; Sagher, U; Ij, Peled; Mr, Wexler; Steiner, D.; Rubinstein, N; Weshler, Z; Or, R.; Slavin, Shimon

doi:10.1097/00007890-198508000-00027

Cited by 32 publications

(14 citation statements)

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“…Pierwszy tego typu zabieg przeprowadzono w 1985 r., a przeszczep skórny pochodził od dawcy szpiku [17]. Do tej pory opisano udane zabiegi przeszczepu skóry pochodzącej zarówno od krewnych HLA-identycznych, jak i niespokrewnionych dawców [7,18,19].…”

Section: Omówienieunclassified

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Chronic graft-versus-host disease – the role of dermatological treatment

Żychowska¹,

Gruber-Kopczyńska²,

Tupikowska-Marzec³

et al. 2017

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Introduction. The number of allogeneic haematopoietic stem cell transplantations is increasing year by year. The most common long-term complication is chronic graft-versus-host disease, with skin involvement noted in over 90% of cases. Objective. To present and discuss skin lesions occurring in chronic graft-versus-host disease with a particular focus on available dermatological treatment modalities. Case report. A 45-year-old male patient, who received allogeneic haematopoietic stem cell transplantations in December 2012, presented for the treatment of skin lesions secondary to chronic graft-versus-host disease. Clinical examination revealed hyperpigmented lichenoid eruption on the trunk; irregular patches of non-scarring alopecia; poikiloderma on the face and upper limbs; and sclerodermatous lesions on the hands with diffuse epidermal exfoliation on the palms and soles. Histopathological examination confirmed the diagnosis of chronic graft-versus-host disease. Treatment consisting of phototherapy and intensive topical treatment was introduced. Conclusions. Skin lesions secondary to chronic graft-versus-host disease may impair the daily functioning of post-transplant patients. Comprehensive therapeutic management should be based on the cooperation between haematologists and dermatologists.

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Section: Omówienieunclassified

“…The first procedure of this type was performed in 1985, and the skin graft was harvested from the bone marrow donor [17]. The literature also contains reports of successful skin grafting both from HLA-identical relatives and unrelated donors [7,18,19].…”

Section: Konflikt Interesówmentioning

confidence: 99%

Chronic graft-versus-host disease – the role of dermatological treatment

Żychowska¹,

Gruber-Kopczyńska²,

Tupikowska-Marzec³

et al. 2017

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“…[22][23][24][25] In humans, BMT has been shown to confer acceptance of donor specific skin and kidney allografts without immunosuppression. 26,27 …”

Section: Chimerismmentioning

confidence: 99%

Mixed allogeneic chimerism and tolerance to composite tissue allografts

et al. 2000

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“…These can be grafted with split thickness skin grafts taken from the donor of the bone marrow. The grafted skin is spared by the GVHD process [15]. This would indicate that chronic GVHD is, in fact, primarily an allogenic immune reac tion.…”

Section: How Does Gvhd Pertain To Clinical Dermatology?mentioning

confidence: 99%

Graft versus Host Reaction: Why Is It Important for the Dermatologist?

Jh¹

1988

Dermatology

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Tolerance to Donor-Type Skin in the Recipient of a Bone Marrow Allograft: Treatment of Skin Ulcers in Chronic Graft-Versus-Host Disease With Skin Grafts From the Bone Marrow Donor

Cited by 32 publications

References 0 publications

Chronic graft-versus-host disease – the role of dermatological treatment

Chronic graft-versus-host disease – the role of dermatological treatment

Mixed allogeneic chimerism and tolerance to composite tissue allografts

Graft versus Host Reaction: Why Is It Important for the Dermatologist?

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