Tolerance to acute hypoxia maximally increases in case of joint effect of normobaric hypoxia and permissive hypercapnia in rats

Tregub, Pavel; Kulikov, V. V.; Bespalov, A. G.

doi:10.1016/j.pathophys.2013.09.001

Cited by 20 publications

(11 citation statements)

References 28 publications

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“…The respiratory exposures were performed in a sealed chamber [5,12]. During training sessions (20 min per day for 15 days), gas mixtures were different for different rat groups.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, new data were reported on the neuroprotective properties of permissive hypercapnia [11,13]. For instance, permissive hypercapnia exerted a pronounced therapeutic effect in experimental brain ischemia/reperfusion [15].We have previously demonstrated that combined exposure to hypoxia and hypercapnia more effectively improved brain tolerance to ischemia/hypoxia than individual exposures to these factors [5,12]. We also showed that the important role in potentiation of the hypoxia-induced neuroprotective effect under conditions of hypercapnia is played by VEGF, HSP-70, and neurotrophic protein S-100B [3].…”

mentioning

confidence: 99%

“…We have previously demonstrated that combined exposure to hypoxia and hypercapnia more effectively improved brain tolerance to ischemia/hypoxia than individual exposures to these factors [5,12]. We also showed that the important role in potentiation of the hypoxia-induced neuroprotective effect under conditions of hypercapnia is played by VEGF, HSP-70, and neurotrophic protein S-100B [3].…”

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confidence: 99%

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Proliferative and Synthetic Activity of Nerve Cells after Combined or Individual Exposure to Hypoxia and Hypercapnia

et al. 2015

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We compared synthetic and proliferative activity of brain cells in rats exposed hypoxia, hypercapnia, or both prior to experimental focal stroke. The mean number of nucleolus organizer regions in penumbra neurons did not change after normobaric hypoxia, but increased after permissive hypercapnia or hypercapnic hypoxia. These data attest to activation of proliferative and synthetic functions in nerve cells, which plays an important role in the neuroprotective mechanisms under conditions of combined exposure to hypoxia and hypercapnia.

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“…The respiratory exposures were performed in a sealed chamber [5,12]. During training sessions (20 min per day for 15 days), gas mixtures were different for different rat groups.…”

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Proliferative and Synthetic Activity of Nerve Cells after Combined or Individual Exposure to Hypoxia and Hypercapnia

et al. 2015

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“…One of the most common methods for determining tolerance to oxygen deficiency is a model that reproduces the conditions of hypobaric hypoxia in decompression chambers, into which volunteers, pilots, astronauts or experimental animals are set [ 9 , 10 , 11 , 12 , 14 , 17 , 18 , 19 , 20 , 21 , 22 , 123 , 124 , 125 , 126 , 127 , 128 , 129 ]. To assess the individual’s hypoxia tolerance, people are exposed to altitudes of several thousand meters [ 99 , 101 , 130 ].…”

Section: Physiological Biochemical and Molecular-biological Charmentioning

confidence: 99%

“…Experimental models of high-altitude human diseases mostly include the use of a decompression chamber [ 189 , 190 , 191 ]. Additionally, among experimental animals, the most common method for determining tolerance to oxygen deficiency is a model that reproduces the conditions of hypobaric hypoxia in decompression chambers by the controlled pumping out of air [ 11 , 14 , 18 , 19 , 128 ].…”

Section: Physiological Biochemical and Molecular-biological Charmentioning

confidence: 99%

Differences in Tolerance to Hypoxia: Physiological, Biochemical, and Molecular-Biological Characteristics

Джалилова

Makarova

2020

Biomedicines

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Hypoxia plays an important role in the development of many infectious, inflammatory, and tumor diseases. The predisposition to such disorders is mostly provided by differences in basic tolerance to oxygen deficiency, which we discuss in this review. Except the direct exposure of different-severity hypoxia in decompression chambers or in highland conditions, there are no alternative methods for determining organism tolerance. Due to the variability of the detection methods, differences in many parameters between tolerant and susceptible organisms are still not well-characterized, but some of them can serve as biomarkers of susceptibility to hypoxia. At the moment, several potential biomarkers in conditions after hypoxic exposure have been identified both in experimental animals and humans. The main potential biomarkers are Hypoxia-Inducible Factor (HIF)-1, Heat-Shock Protein 70 (HSP70), and NO. Due to the different mechanisms of various high-altitude diseases, biomarkers may not be highly specific and universal. Therefore, it is extremely important to conduct research on hypoxia susceptibility biomarkers. Moreover, it is important to develop a method for the evaluation of organisms’ basic hypoxia tolerance without the necessity of any oxygen deficiency exposure. This can contribute to new personalized medicine approaches’ development for diagnostics and the treatment of inflammatory and tumor diseases, taking into account hypoxia tolerance differences.

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Hypercapnic hypoxia as a potential means to extend life expectancy and improve physiological activity in mice

et al. 2019

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Tolerance to acute hypoxia maximally increases in case of joint effect of normobaric hypoxia and permissive hypercapnia in rats

Cited by 20 publications

References 28 publications

Proliferative and Synthetic Activity of Nerve Cells after Combined or Individual Exposure to Hypoxia and Hypercapnia

Proliferative and Synthetic Activity of Nerve Cells after Combined or Individual Exposure to Hypoxia and Hypercapnia

Differences in Tolerance to Hypoxia: Physiological, Biochemical, and Molecular-Biological Characteristics

Hypercapnic hypoxia as a potential means to extend life expectancy and improve physiological activity in mice

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