Tolerance potential of Chilo suppressalis larvae to fipronil exposure via the modulation of detoxification and GABA responses

Xiao, Ciying; Luan, Shaorong; Xu, Zhikang; Lang, Jialin; Rao, Wenbing; Huang, Qingchun

doi:10.1016/j.aspen.2017.09.013

Cited by 6 publications

(2 citation statements)

References 39 publications

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“…However, the overexpression of such enzymes can also occur only after contact with sublethal concentrations of insecticides in susceptible individuals. This phenomenon of increased expression of detoxifying enzymes was observed in a susceptible population of Anopheles coluzzii after sublethal exposure to pyrethroids [68], and this is probably a common response among insects [69][70][71]. This overexpression of enzymes leads to energetic costs that may negatively impact several lifehistory traits related to fitness.…”

Section: Sublethal Exposure Of Adults To Insecticidesmentioning

confidence: 82%

Implications of Sublethal Insecticide Exposure and the Development of Resistance on Mosquito Physiology, Behavior, and Pathogen Transmission

Andreazza

Oliveira

Martins

2021

Insects

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For many decades, insecticides have been used to control mosquito populations in their larval and adult stages. Although changes in the population genetics, physiology, and behavior of mosquitoes exposed to lethal and sublethal doses of insecticides are expected, the relationships between these changes and their abilities to transmit pathogens remain unclear. Thus, we conducted a comprehensive review on the sublethal effects of insecticides and their contributions to insecticide resistance in mosquitoes, with the main focus on pyrethroids. We discuss the direct and acute effects of sublethal concentrations on individuals and populations, the changes in population genetics caused by the selection for resistance after insecticide exposure, and the major mechanisms underlying such resistance. Sublethal exposures negatively impact the individual’s performance by affecting their physiology and behavior and leaving them at a disadvantage when compared to unexposed organisms. How these sublethal effects could change mosquito population sizes and diversity so that pathogen transmission risks can be affected is less clear. Furthermore, despite the beneficial and acute aspects of lethality, exposure to higher insecticide concentrations clearly impacts the population genetics by selecting resistant individuals, which may bring further and complex interactions for mosquitoes, vertebrate hosts, and pathogens. Finally, we raise several hypotheses concerning how the here revised impacts of insecticides on mosquitoes could interplay with vector-mediated pathogens’ transmission.

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Section: Sublethal Exposure Of Adults To Insecticidesmentioning

confidence: 82%

Implications of Sublethal Insecticide Exposure and the Development of Resistance on Mosquito Physiology, Behavior, and Pathogen Transmission

Andreazza

Oliveira

Martins

2021

Insects

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“…In the study by Zhao et al (2018), the GST activity in the maggots of Bradysia odoriphaga (Diptera: Sciaridae) treated with chlorfenapyr at LC20 and LC50 concentrations did not significantly differ from the control [ 53 ]. The GST and P450 activities were shown to be decreased in the fourth instar larvae of Chilo suppressalis after being topically treated by fipronil at an LD80 dosage [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of Insecticides at Sublethal Concentrations on the Enzyme Activities in Adult Musca domestica L.

Kinareikina

Silivanova

2023

Toxics

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Nowadays, the use of pesticides is, as before, the most common way to control arthropod plant pests and the ectoparasites of animals. The sublethal effects of pesticides on insects can appear at different levels, from genetics to populations, and the study of these effects is important for a better understanding of the environmental and evolutionary patterns of pesticidal resistance. The current study aimed to assess the sublethal effects of chlorfenapyr and fipronil on the activities of detoxifying enzymes (carboxylesterase—CarE, acetylcholinesterase—AChE, glutathione-S-transferase—GST, and cytochrome P450 monooxygenase—P450) in adults Musca domestica L. The insects were exposure to insecticides by a no-choice feeding test and the enzyme activities and the AChE kinetic parameters were examined in female and male specimens at 24 h after their exposure. According to Tukey’s test, the CarE activity was statistically significantly decreased by 29.63% in the females of M. domestica after an exposure to chlorfenapyr at a concentration of 0.015% when compared to the controls (p ≤ 0.05). An exposure to the sublethal concentration of fipronil (0.001%) was followed by a slightly decrease in the specific activity (33.20%, p ≤ 0.05) and the main kinetic parameters (Vmax, Km) of AChE in females in comparison with the control values. The GST and P450 activities had not significantly changed in M. domestica males and females 24 h after their exposure to chlorfenapyr and fipronil at sublethal concentrations. The results suggest that the males and females of M. domestica displayed biochemically different responses to fipronil, that is a neurotoxin, and chlorfenapyr, that is a decoupler of oxidative phosphorylation. Further research needs to be addressed to the molecular mechanisms underlying the peculiarities of the insect enzyme responses to different insecticides.

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Interaction of fipronil and the red imported fire ant (Solenopsis invicta): Toxicity differences and detoxification responses

Xiong

Qiu

Ling

et al. 2019

Journal of Insect Physiology

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Tolerance potential of Chilo suppressalis larvae to fipronil exposure via the modulation of detoxification and GABA responses

Cited by 6 publications

References 39 publications

Implications of Sublethal Insecticide Exposure and the Development of Resistance on Mosquito Physiology, Behavior, and Pathogen Transmission

Implications of Sublethal Insecticide Exposure and the Development of Resistance on Mosquito Physiology, Behavior, and Pathogen Transmission

Impact of Insecticides at Sublethal Concentrations on the Enzyme Activities in Adult Musca domestica L.

Interaction of fipronil and the red imported fire ant (Solenopsis invicta): Toxicity differences and detoxification responses

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