Tolerance of Therapeutic Doses of Abamectin and Doramectin in Istrian Pramenka Sheep

Abstract

Avermectin endectocides are very effective and safe veterinary drugs, when used at recommended doses. Adverse reactions are described in some species and breeds of animals. In this study, the effects of therapeutic doses of abamectin and doramectin on some haematological and biochemical parameters in Istrian Pramenka sheep are discussed. In the pilot trial, we compared selected haematological and blood biochemical parameters of an experimental sheep flock (40 sheep) with the reference values. Then, two groups of 12 sheep (and their suckling lambs) were chosen from the experimental sheep flock. Each group was subdivided into a control (six animals) and treated (six sheep and their six suckling lambs) groups. We compared haematological and biochemical parameters between control and treated group before subcutaneous administration of abamectin or doramectin (0.2 mg/kg b.w.) and on days 15 and 42 after treatment. In addition, animals were observed for neurological signs. We detected some significant differences (P < 0.05) in some haematological and biochemical parameters between control and treated animals, but none of them appeared to be of clinical importance. No neurological symptoms were observed. Therefore, abamectin and doramectin might be well tolerated in Istrian Pramenka sheep.

Experimental Exposure to Bisphenol A Has Minimal Effects on Bone Tissue in Growing Rams—A Preliminary Study

“…Basic blood analysis was performed before the procedure; blood was collected in the morning before pellets were administered [ 46 ]. Vital signs (body temperature, pulse, respiratory rate, ruminations) and serum biochemistry parameters ( Supplementary Table S1 ) were consistent with a previous study of this breed [ 47 ].…”

“…We analyzed bone turnover markers, femoral growth and geometry (the distal EGP and trabecular microarchitecture), and mineral content and investigated to what extent these parameters influence bone biomechanical behavior in young, growing rams, given the similarities of sheep bone anatomy, trabecular structure, and mineral metabolism to humans [ 44 ]. A two-month exposure to a daily dose of 25 µg BPA/kg bw/day showed no systemic or acute effects on rams, and this finding was also supported by relative liver mass and serum parameters of liver and kidney function, as they were in previously reported ranges for sheep breed Istrian Pramenka [ 47 ]. Serum and bone parameters of bone metabolism, mass, geometry (length, width, cross-sectional architecture), mineral content, and biomechanics seemed to be only slightly affected in the BPA group, suggesting no major biological effects in long bone tissues.…”

“…The high serum PO 4 concentration in all animals before BPA administration reflected their age and intense growth and possibly the daily administration of concentrated pellets. Therefore, the significant decrease in phosphate and increase in Ca:P ratio throughout the procedure—with increasing age—toward the Ca:P ratio common to adult animals, i.e., 1.37–1.86 [ 47 ], was expected and should not be considered an effect of BPA treatment. Decreased levels of AST and increased levels of GGT activity, although still in the physiological range (also reported when low doses of BPA were administered to rats [ 60 ]), could indicate a disturbance in biliary excretion [ 61 ], although the relative liver mass was not affected in the present study.…”

Haemaphysalis concinna(Acari: Ixodida): Persistent efficacy of doramectin in rabbits under laboratory conditions

“…Doramectin (DOR) has been widely used to control ectoparasites and internal parasites (Lloyd et al 1996;Kanbur et al 2008;van der Merwe et al 2008). In clinical trials, it was found to be highly effective, broad-spectrum and safe for animal (cattle, sheep, dogs and pigs) use (Yazwinski et al 1997;Lavy et al 2002;Kuzner et al 2005;Bengone-Ndong et al 2008;Zacharias et al 2008).…”