Tolerance of intravenous indomethacin treatment for premature infants with patent ductus arteriosus.

Abstract

eight patients who had a stable or partial response, suggesting that, in addition to causing sclerosis of bone, APD may have an antitumour effect. Factors released from tumours stimulate osteoblastic activity3 and osteolysis mediated by osteoclasts.4 APD is a potent inhibitor of osteoclast function, and such inhibition combined with the osteoblastic factors produced by tumour cells may explain the bony sclerosis seen in this study.APD reduces morbidity from lytic metastases when used in conjunction with standard chemotherapy,' and this study shows that it may be active when used alone.We are grateful to the staff of the day ward, Christie Hospital; the departments of chemical pathology at Christie Hospital and Withington Hospital; Mrs H Morten and Mr J Turnbull for performing the radioimmunoassays; and Ciba-Geigy Ltd for supplies of

Can Dopamine Prevent the Renal Side Effects of Indomethacin?

“…The dose and the duration of the indomethacin application are still controversial [9] but most neonatal intensive care units use the classical 3 dose course with a 0.2 mg/kg/dose. The adverse effects occurring with intravenous administration of indomethacin in premature infants are a fall in cerebral blood flow [12], reversible renal failure [10,18] reduced intestinal blood flow [14], decreased platelet function [26], and increased bleeding other than intracerebral haemorrhage [1,5]. There are several studies advocating different drugs to prevent the indomethacin induced renal failure [4,18,21,24].…”

Excretion of indomethacin in breast milk.

“…Our data show that infants could ingest only relatively small amounts of indomethacin via breast milk. For example, the maximum absolute daily dose (0.017 mg kg-' day-'), corresponds to only 4.2-8.5% of the intravenous dose of indomethacin (0.2 mg kg-' 12-24 hourly for three doses) used to treat patent ductus arteriosus (Walters, 1988). The total indomethacin dose exposure of the infants, calculated as the relative dose in milk was extremely low.…”