Tolerance of inorganic selenium in wether sheep

Cristaldi, Laura; McDowell, L. R.; Buergelt, C. D.; Davis, Philip A.; Wilkinson, N. S.; Martin, F. G.

doi:10.1016/j.smallrumres.2004.06.001

Cited by 60 publications

(55 citation statements)

References 16 publications

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“…At enrolment, HSY lambs had higher (P , 0.001) whole-blood Se concentrations than C (766.4 v. 216.4 ng Se per ml), as would be expected from animals that had been previously exposed to high doses of Se. These values were similar to those found in pregnant ewes (Davis et al, 2006) and wether lambs (Cristaldi et al, 2005) that had received comparable Se doses in the form of SS. Similarly, whole-blood Se concentrations were still significantly higher (P , 0.001) in HSY animals at PT 21 and PT 42 when compared with C, although HSY whole-blood total Se values were seen to decline between successive time points (P , 0.001), whereas those of C remained relatively constant.…”

Section: Feed Analysessupporting

confidence: 85%

“…Among HSY animals, the concentration of total Se at PT 0 was highest in the liver (22.64 mg/kg DM), which declined significantly to approximately 35% of PT 0 values by PT 21 and 20% by PT 42 ). Similar Se concentrations to those of HSY animals at PT 0 have been recorded in the liver of pregnant ewes (Davis et al, 2006) and wether lambs (Cristaldi et al, 2005) that had received comparable doses as SS. The total Se content of kidney in HSY animals at PT 0 was 18.96 mg/kg DM; this value was higher than those reported for pregnant ewes (Davis et al, 2006) and wether lambs (Cristaldi et al, 2005), indicating that Se source may influence Se retention between different tissues.…”

Section: Feed Analysessupporting

confidence: 68%

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Selenium persistency and speciation in the tissues of lambs following the withdrawal of dietary high-dose selenium-enriched yeast

Juniper

Phipps

Ramos-Morales

et al. 2008

Animal

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The objective was to determine the concentration of total selenium (Se) and the proportion of total Se comprised as selenomethionine (SeMet) and selenocysteine (SeCys) in post mortem tissues of lambs in the 6 weeks period following the withdrawal of a diet containing high-dose selenised yeast (HSY), derived from a specific strain of Saccharomyces cerevisae CNCM (Collection Nationale de Culture de Micro-organism) I-3060. Thirty Texel 3 Suffolk lambs used in this study had previously received diets (91 days) containing either HSY (6.30 mg Se per kg dry matter (DM)) or an unsupplemented control (C; 0.13 mg Se per kg DM). Following the period of supplementation, all lambs were then offered a complete pelleted diet, without additional Se (0.15 mg Se per kg DM), for 42 days. At enrolment and 21 and 42 days later, five lambs from each treatment were blood sampled, euthanased and samples of heart, liver, kidney and skeletal muscle (longissimus dorsi and psoas major) tissue were retained. Total Se concentration in whole blood and tissues was significantly (P , 0.001) higher in HSY lambs at all time points that had previously received long-term exposure to high dietary concentrations of SY. The distribution of total Se and the proportions of total Se comprised as SeMet and SeCys differed between tissues, treatment and time points. Total Se was greatest in HSY liver and kidney (22.64 and 18.96 mg Se per kg DM, respectively) and SeCys comprised the greatest proportion of total Se. Conversely, cardiac and skeletal muscle (longissimus dorsi and psoas major) tissues had lower total Se concentration (10.80, 7.02 and 7.82 mg Se per kg DM, respectively) and SeMet was the predominant selenised amino acid. Rates of Se clearance in HSY liver (307 mg Se per day) and kidney (238 mg Se per day) were higher compared with HSY cardiac tissue (120 mg Se per day) and skeletal muscle (20 mg Se per day). In conclusion, differences in Se clearance rates were different between tissue types, reflecting the relative metabolic activity of each tissue, and appear to be dependent on the proportions of total Se comprised as either SeMet or SeCys.

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Section: Feed Analysessupporting

confidence: 85%

Section: Feed Analysessupporting

confidence: 68%

Selenium persistency and speciation in the tissues of lambs following the withdrawal of dietary high-dose selenium-enriched yeast

Juniper

Phipps

Ramos-Morales

et al. 2008

Animal

View full text Add to dashboard Cite

show abstract

“…Cristaldi et al (2005) stated that Se concentrations in serum generally reflect the level of dietary Se, as is evident from Fig. 1.…”

Section: Selenium Concentrations After Commencement Of Supplementationmentioning

confidence: 76%

“…Consequently, graphs are presented in which plasma/serum Se concentrations have apparently reached a steady-state by day 20 (Van Ryssen et al, 1989), have peaked by four weeks (Nicholson et al, 1991), (Hartmann and Van Ryssen, 1997), by 21 days or within 14 days (Taylor, 2005). However, after the first collection at four weeks, over 52 weeks Cristaldi et al (2005) recorded increasing concentrations of Se in the serum of sheep receiving inorganic Se. This was more pronounced at the higher dietary Se concentrations, which ranged from 0.2 mg/kg to 10 mg/kg than at the lower levels of intake.…”

Section: Selenium Concentrations After Commencement Of Supplementationmentioning

confidence: 99%

“…Since whole blood and plasma Se concentrations seem to continue to increase with time after commencement of supplementation (Knowles et al, 1999;Cristaldi et al, 2005), the time of reaching steady-state is probably somewhat arbitrary. However, in the present investigation, the ratios between Se in whole blood and plasma showed quite a distinct pattern of reaching a stabilizing point at between 50 and 70 days after commencement of Se supplementation.…”

Section: Ratio Between Selenium In Whole Blood and Plasmamentioning

confidence: 99%

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Time-dependent effect of selenium supplementation on the relationship between selenium concentrations in whole blood and plasma of sheep

Ryssen

Coertze

Smith³

2013

Small Ruminant Research

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The ratio between selenium (Se) concentrations in pairs of plasma and whole blood of sheep after commencement of Se supplementation was calculated from data obtained from 10 independent investigations. The diets in the studies consisted of a variety of ingredients, from the individual feeding of feedlot diets to grazing trials on Se-deficient pastures. Means from 51 treatments, derived from 179 collections at various stages after commencement of Se supplementation, were used to calculate the ratios. In one study it was found that plasma Se concentration reached steady-state within 4 days of commencement, while Se in whole blood reached steady-state only at the collection 60 days after supplementation commenced. Using the 179 pairs, the ratio of whole blood and plasma stabilized at about 50 days after commencement when inorganic Se was supplemented, and at about 60-70 days when the Se was in the organic form. The ratios stabilized when they were between 2:1 and 3:1, and remained practically constant from 50 days post onset of supplementation, when plasma Se constituted 0.445 of whole blood Se concentration for the inorganic Se source and 0.410 when the Se source was organic. It was concluded that after commencement of Se intake, plasma Se concentration remains relatively constant from within 4 days of onset, while whole blood Se concentration apparently reaches steady-state only after approximately 50 days. Before 50 days, whole blood Se seems not to be reliable to predict the Se status of an animal. In a situation where Se intake is stable and Se requirements do not fluctuate, a bloodplasma ratio of between 2:1 and 3:1 would be a guideline to indicate that whole blood Se and plasma Se concentrations could both be used to assess the Se status of sheep.

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Fabaceae Lindl.

and¹,

Tyrl²

2012

Toxic Plants of North America

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Tolerance of inorganic selenium in wether sheep

Cited by 60 publications

References 16 publications

Selenium persistency and speciation in the tissues of lambs following the withdrawal of dietary high-dose selenium-enriched yeast

Selenium persistency and speciation in the tissues of lambs following the withdrawal of dietary high-dose selenium-enriched yeast

Time-dependent effect of selenium supplementation on the relationship between selenium concentrations in whole blood and plasma of sheep

Fabaceae Lindl.

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