Tolerance and osteointegration of TricOs<sup>TM</sup>/MBCP<sup>®</sup>in association with fibrin sealant in mastoid obliteration after canal wall-down technique for cholesteatoma

Franco-Vidal, V.; Daculsi, Guy; d'Arc, Maurice Bagot; Sterkers, Olivier; Smail, Mustapha; Robier, A.; Bordure, Philippe; Clarós, Pedro; Paiva, António; Darrouzet, V.; Anthoine, Emmanuelle; Bébéar, J. P.

doi:10.3109/00016489.2013.859394

Cited by 18 publications

(7 citation statements)

References 11 publications

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“…The addition of the calcium phosphate material and mesenchymal stem cells to the FBP scaffold during the surgery improved the handling and application of the association due to the formation of a moldable composite, thus reducing the time of the surgical procedure [55-58]. This was due to the malleability of the dense fibrin network formed during the stabilization of the clot [30] .…”

Section: Discussionmentioning

confidence: 99%

Fibrin biopolymer as scaffold candidate to treat bone defects in rats

Cassaro

Justulin

Lima

et al. 2019

J. Venom. Anim. Toxins incl. Trop. Dis

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Background: Bone tissue repair remains a challenge in tissue engineering. Currently, new materials are being applied and often integrated with live cells and biological scaffolds. The fibrin biopolymer (FBP) proposed in this study has hemostatic, sealant, adhesive, scaffolding and drug-delivery properties. The regenerative potential of an association of FBP, biphasic calcium phosphate (BCP) and mesenchymal stem cells (MSCs) was evaluated in defects of rat femurs.Methods: Adult male Wistar rats were submitted to a 5-mm defect in the femur. This was filled with the following materials and/or associations: BPC; FBP and BCP; FBP and MSCs; and BCP, FBP and MSCs. Bone defect without filling was defined as the control group. Thirty and sixty days after the procedure, animals were euthanatized and subjected to computed tomography, scanning electron microscopy and qualitative and quantitative histological analysis.Results:It was shown that FBP is a suitable scaffold for bone defects due to the formation of a stable clot that facilitates the handling and optimizes the surgical procedures, allowing also cell adhesion and proliferation. The association between the materials was biocompatible. Progressive deposition of bone matrix was higher in the group treated with FBP and MSCs. Differentiation of mesenchymal stem cells into osteogenic lineage was not necessary to stimulate bone formation.Conclusions:FBP proved to be an excellent scaffold candidate for bone repair therapies due to application ease and biocompatibility with synthetic calcium-based materials. The satisfactory results obtained by the association of FBP with MSCs may provide a more effective and less costly new approach for bone tissue engineering.

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Section: Discussionmentioning

confidence: 99%

Fibrin biopolymer as scaffold candidate to treat bone defects in rats

Cassaro

Justulin

Lima

et al. 2019

J. Venom. Anim. Toxins incl. Trop. Dis

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“…Erkkola-Anttinen N, Laine MK, Tahtinen PA, et al OM2015047 (214) Showed that spectral acoustic reflectometry is not accurate in excluding ME effusion in symptomatic children.…”

Section: Middle Earmentioning

confidence: 99%

“…Kanemaru et al examined the ability of regenerated MACS to restore normal gas exchange and improve ETF in patients with COM. 210 Although an ideal material for mastoid air cell regeneration has not yet been identified, several materials have been investigated, including ceramic-based biphasic calcium phosphate granules [211][212][213] mixed with fibrin sealant, 214 polycaprolactone-tricalcium phosphate 215 composites, artificial or biologic hydroxyapatite, 216,217 autogenous bone cement, 218 and bioactive glass. 219 Biodegradable materials 220 and biomaterials coated with growth factors 221,222 have been investigated and/or encapsulated with cultured ME mucosal epithelial cells 223 and supplemented with collagen nanofibers.…”

Section: Physiology and Pathophysiologymentioning

confidence: 99%

Panel 2: Anatomy (Eustachian Tube, Middle Ear, and Mastoid—Anatomy, Physiology, Pathophysiology, and Pathogenesis)

Alper

Luntz

Takahashi

et al. 2017

Otolaryngol.--head neck surg.

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Objective. In this report, we review the recent literature (ie, past 4 years) to identify advances in our understanding of the middle ear-mastoid-eustachian tube system. We use this review to determine whether the short-term goals elaborated in the last report were achieved, and we propose updated goals to guide future otitis media research.Data Sources. PubMed, Web of Science, Medline.Review Methods. The panel topic was subdivided, and each contributor performed a literature search within the given time frame. The keywords searched included middle ear, eustachian tube, and mastoid for their intersection with anatomy, physiology, pathophysiology, and pathology. Preliminary reports from each panel member were consolidated and discussed when the panel met on June 11, 2015. At that meeting, the progress was evaluated and new short-term goals proposed.Conclusions. Progress was made on 13 of the 20 short-term goals proposed in 2011. Significant advances were made in the characterization of middle ear gas exchange pathways, modeling eustachian tube function, and preliminary testing of treatments for eustachian tube dysfunction.Implications for Practice. In the future, imaging technologies should be developed to noninvasively assess middle ear/eustachian tube structure and physiology with respect to their role in otitis media pathogenesis. The new data derived from these structure/function experiments should be integrated into computational models that can then be used to develop specific hypotheses concerning otitis media pathogenesis and persistence. Finally, rigorous studies on medical or surgical treatments for eustachian tube dysfunction should be undertaken.

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“…Для облитерации МП используют ауто-, алло-, ксеноткани, а также различные биосовместимые материалы (метакрилат, керамика, гидроксиапатит и так далее) [12,13].…”

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The application of mastoidoplasty in repeated scanning operations on the ear

2016

Vestn. otorinolaringol.

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The objective of the present study was to evaluate the outcomes of mastoid obliteration with the use of the orthotopic bone tissue taken from the linea temporalis region. It was shown that this region is the optimal site at the temporal bone for the harvesting of the plastic bone material to be used in mastoidoplasty during secondary sanitizing surgical interventions on the patients with mastoid cavity problems after canal wall-down mastoidrctomy under conditions of the deficiency of the orthotopic bone tissue. The application of such tissue for the purpose of mastoid-obliteration surgery provides a number of advantages over other methods of mastoidoplasty, in the first place from the standpoint of tissue biocompatibility. Multispiral computed tomography (MSCT) of the temporal bones is a highly informative and non-invasive technique for the study and control of the patients' condition during the late postoperative period following a secondary sanitizing surgical intervention involving mastoidoplasty with the application of the orthotopic bone tissue.

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Tolerance and osteointegration of TricOs^TM/MBCP^®in association with fibrin sealant in mastoid obliteration after canal wall-down technique for cholesteatoma

Cited by 18 publications

References 11 publications

Fibrin biopolymer as scaffold candidate to treat bone defects in rats

Fibrin biopolymer as scaffold candidate to treat bone defects in rats

Panel 2: Anatomy (Eustachian Tube, Middle Ear, and Mastoid—Anatomy, Physiology, Pathophysiology, and Pathogenesis)

The application of mastoidoplasty in repeated scanning operations on the ear

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Tolerance and osteointegration of TricOsTM/MBCP®in association with fibrin sealant in mastoid obliteration after canal wall-down technique for cholesteatoma

Cited by 18 publications

References 11 publications

Fibrin biopolymer as scaffold candidate to treat bone defects in rats

Fibrin biopolymer as scaffold candidate to treat bone defects in rats

Panel 2: Anatomy (Eustachian Tube, Middle Ear, and Mastoid—Anatomy, Physiology, Pathophysiology, and Pathogenesis)

The application of mastoidoplasty in repeated scanning operations on the ear

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Tolerance and osteointegration of TricOs^TM/MBCP^®in association with fibrin sealant in mastoid obliteration after canal wall-down technique for cholesteatoma