Tolerability and safety of commonly used dietary supplements and nutraceuticals with lipid-lowering effects

Middle-Term Dietary Supplementation with Red Yeast Rice Plus Coenzyme Q10 Improves Lipid Pattern, Endothelial Reactivity and Arterial Stiffness in Moderately Hypercholesterolemic Subjects

“…Nutraceuticals and dietary supplements with a supposed or demonstrated ability to lower cholesterolemia, which may represent in some patients an alternative to statins, have been lately studied extensively [1,2] . Among these compounds are monacolins, policosanols, berberine [3] , phytosterols, soluble fibers, omega 3 polyunsaturated fatty acids [4,5] , soy proteins and garlic extracts.…”

Berberis aristata/Silybum marianum fixed combination (Berberol®) effects on lipid profile in dyslipidemic patients intolerant to statins at high dosages: A randomized, placebo-controlled, clinical trial

“…One strategy to reduce the risk of statin-induced adverse events includes using a lower dosage, however this consequently leads to a lower benefit on lipid profile. In the latest years relatively large number of dietary supplements and nutraceuticals have been studied for their supposed or demonstrated ability to reduce cholesterolemia in humans (Cicero et al 2008(Cicero et al , 2012. These supplements include soluble fibers, phytosterols, soy proteins (Cicero et al, 2004), omega 3 polyunsaturated fatty acids (Derosa et al, 2011(Derosa et al, , 2012a, red yeast rice (Cicero et al, 2013), policosanols, berberine both alone (Derosa et al, 2012b(Derosa et al, , 2013a or in combination with Silybum marianum (Derosa et al, 2013b,c), and garlic extracts.…”

Red yeast rice improves lipid pattern, high-sensitivity C-reactive protein, and vascular remodeling parameters in moderately hypercholesterolemic Italian subjects

“…A relatively large number of dietary supplements and nutraceuticals have been studied for their supposed or demonstrated ability to reduce cholesterolemia in humans [1,2]. These supplements include soluble fibers, phytosterols, soy proteins, omega 3 polyunsaturated fatty acids [3,4], monacolins, policosanols, berberine [5], and garlic extracts.…”