Tokographische Untersuchungen zur medikament�sen Wehenhemmung

Review article

“…These publications escaped notice in the German-speaking countries for some time. In 1961 we introduced nylidrin (buphenine, Dik-tol®), a substance of similar composition which had akeady been tested on humans in Germany [17,38,55] (Fig. 1), into the treatment of premature labor.…”

“…Doses which were eflfective in the Uterus led to considerable side effects. In subsequent years new ^sympathomimetics, kst fenoterol (Th 1165a), were studied experimentally and therapeutically [17,29,38,40]. Substances with a difFetent mode of action, such äs ethyl alcohol [24], spasmolytic agents of the calcium antagonistic type [23,40,41] and, recently, prostagkndin antagonists were also therapeutically tested [2 9 43], To date no drug which acts exlusively or primärily on the myometrium has been found.…”

“…

Tocolysis means drug-induced Inhibition of premature or excessive uterine activity [38], Other terms, such äs "sedation of the irritated myometrium" or "relaxation of the uterus" have the same meaning; they are, however, not commonly applied [10,11,17,29]. At the beginning of the research for new substances with inhibitory effect on the uterus it was postulated that progesterone or newlydeveloped gestagen preparations could inhibit uterine activity.

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