Toenail selenium status and risk of subtypes of head-neck cancer: The Netherlands Cohort Study

Maasland, Denise Helena Elisabeth; Schouten, Leo J.; Kremer, Bernd; Brandt, Piet A. van den

doi:10.1016/j.ejca.2016.03.003

Cited by 20 publications

(10 citation statements)

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“…Our group has previously shown that low selenium is associated with an increased risk of laryngeal cancer in Poland, a geographic area with endemically low levels of soil selenium[ 10 ]. The role of selenium status on cancer risk for head and neck cancers remains uncertain [ 11 – 14 ]. To our knowledge, there have been no studies specifically evaluating the role of low circulating selenium levels and prognosis specifically following a diagnosis of laryngeal cancer.…”

Section: Introductionmentioning

confidence: 99%

Serum selenium levels and the risk of progression of laryngeal cancer

et al. 2018

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BackgroundObservational studies have reported an inverse relationship between selenium status (blood or toenail) and the risk of laryngeal cancer; however, the impact of low serum selenium level on survival has not been evaluated.MethodsWe conducted a prospective study of 296 patients diagnosed with laryngeal cancer in Szczecin, Poland. Serum selenium was measured at diagnosis and prior to treatment. Patients were followed from the date of diagnosis to death at five years. Vital status was obtained by linkage to the Polish National Death Registry.ResultsThe five-year survival after diagnosis was 82.0% (95% CI: 68% to 91%) for individuals in the highest quartile of serum selenium (> 66.8 μg/L) and was 28.6% (95% CI 19% to 42%) for individuals in the lowest quartile (<50.0 μg/L). In an age- and sex-adjusted analysis, the hazard ratio (HR) for death from all causes was 7.01 (95% CI 3.81 to 12.9) for patients in the lowest quartile of serum selenium, compared to those in the highest quartile. The corresponding multivariate HR was 3.07 (95% CI 1.59 to 5.94).ConclusionsThis study suggests that a selenium level in excess of 70 μg/L is associated with improved outcome among patients undergoing treatment for laryngeal cancer. Further studies are needed to evaluate if selenium supplementation to achieve this level might improve overall prognosis.

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Section: Introductionmentioning

confidence: 99%

Serum selenium levels and the risk of progression of laryngeal cancer

et al. 2018

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“…The Nurses’ Health and Health Professional studies in the USA have shown that average concentrations of toenail Se were 0·77 ( sd 0·13) μg/g in men and 0·84 ( sd 0·15) μg/g in women ( 38 ) . The average concentrations of toenail Se in the Netherlands Cohort Study in Europe were relatively lower at 0·55 ( sd 0·13) μg/g in men and 0·57 ( sd 0·15) μg/g in women ( 39 ) . The average concentrations of toenail Se in the SELEN participants were 0·68 ( sd 0·08) μg/g in men and 0·70 ( sd 0·09) μg/g in women, which fall in between values reported in the USA and Europe.…”

Section: Discussionmentioning

confidence: 88%

Toenail selenium levels and prevalence of dyslipidaemia among Korean adults

2017

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Multiple studies have elucidated the antioxidant properties of Se, which are now well known among the nutrition and biomedical science communities. Recently, considerable interest has been focused on the possible association between Se exposure and risk of metabolic disease, such as lipid dysregulation; however, there is limited epidemiological data on this topic. The present study aimed to investigate associations between toenail Se levels and dyslipidaemia or individual lipid levels, and to examine the effect of dietary supplement use on these associations. We analysed baseline data from a cohort in the Yeungnam area, including 232 men and 269 women. Information on demographic, dietary and lifestyle characteristics was obtained through a self-reported questionnaire. Se levels in toenail specimens were measured using neutron activation analysis. Fasting blood lipid levels were measured during medical examinations. After adjusting for multiple confounding variables, we observed no association between toenail Se levels and dyslipidaemia or individual lipid profiles. However, the association was modified by dietary supplement use. Among the supplement users, higher toenail Se levels were associated with a higher prevalence of lipid dysregulation, whereas non-users exhibited a lower prevalence of lipid dysregulation. Associations between toenail Se levels, lipid levels and dyslipidaemia may be influenced by taking dietary supplements. Future large-scale, prospective cohort studies should be conducted to further evaluate the association between Se levels in the body and metabolic health effects in light of increasing rates of dietary supplement use.

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“…In general, Europeans are considered to have lower intakes of selenium since European countries tend to have lower soil selenium levels . For example, participants from a cohort study in the Netherlands had toenail selenium levels of 0.55 μg g −1 for men and 0.58 μg g −1 for women .…”

Section: Discussionmentioning

confidence: 99%