Toehold Strand Displacement-Mediated Exponential HCR for Highly Sensitive and Specific Analysis of miRNA in Living Cells
Mengxu Sun,
Qianying Zhou,
Jing Peng
et al.
Abstract:As an important disease biomarker, the development of
sensitive
detection strategies for miRNA, especially intracellular miRNA imaging
strategies, is helpful for early diagnosis of diseases, pathological
research, and drug development. Hybridization chain reaction (HCR)
is widely used for miRNA imaging analysis because of its high specificity
and lack of biological enzymes. However, the classic HCR reaction
exhibits linear amplification with low efficiency, limiting its use
for the rapid analysis of trace miRN… Show more
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