Tocotrienols have a nephroprotective action against lipid-induced chronic renal dysfunction in rats

Khan, Mohammad Rashid; Ahsan, Haseeb; Siddiqui, Shahla; Siddiqui, Waseem Ahmad

doi:10.3109/0886022x.2014.959433

Cited by 23 publications

(15 citation statements)

References 31 publications

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“…Being among the most widely available natural antioxidants, tocopherols (TOH), especially α‐ and γ‐tocopherol, have been found in vegetable oils (Wagner & Elmadfa, 2000). Many physiological functions, such as hypolipidemic, antiatherogenic, antihypertensive, and neuroprotective effects, have been attributed to the tocopherols and tocotrienols (Franco et al., 2019; Kizhakekuttu & Widlansky, 2010; Rashid Khan et al, 2015; Shahidi & De Camargo, 2016).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant capacity, physicochemical properties, thermal behavior, and oxidative stability of nectarine (Prunus persica var. nucipersica) kernel oil

Sodeifian

Sajadian

2021

J. Food Process. Preserv.

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The current work is focused on the evaluation of oxidative stability, thermal behavior, antioxidant activity, phenolic content, and physicochemical properties of nectarine kernel oil. The antioxidant activity of the oil was remarkably high, that is, IC50 = 95.1 μg/ml. Thermogravimetric experiments indicated thermal stability of the oil at temperatures up to 261°C, where only 2% mass loss was observed, and the oil decomposition occurred in three main stages. Total phenolic content was found to be 334.5 mg GAE/100 g oil. The extracted oil was highly stable for up to 20.92 hr, as per calculations by the Rancimat method. Gas chromatography analysis demonstrated that the extracted oil consisted mainly of unsaturated fatty acids that formed some 92% wt% of the total content. Among others, the fatty acids were mainly composed of oleic (74.55%) and linoleic acids (16.85%). The extracted oil was characterized. The results highlighted the potentials of the nectarine kernel oil for enriching various pharmaceutical products and human nutrition. Practical applications Nectarine (Prunus persica var. nucipersica) is of high commercial value thanks to its outstanding properties such as oxidative stability, thermal behavior, and antioxidant activity. This investigation's outcomes are beneficial to the research and development activities focused on the commercial‐scale processing of nectarine seeds.

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Section: Introductionmentioning

confidence: 99%

Antioxidant capacity, physicochemical properties, thermal behavior, and oxidative stability of nectarine (Prunus persica var. nucipersica) kernel oil

Sodeifian

Sajadian

2021

J. Food Process. Preserv.

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“…This shows that the actions of the antioxidants in fresh palm oil far outweigh the actions of the saturated palmitic acid. This is supported by Several investigators who reported that tocotrienols T3 have strong antioxidant activity and protects efficiently against some free radical-related diseases [34,9].…”

Section: Discussionmentioning

confidence: 53%

“…It is the largest natural source of tocotrienol which is the most potent form of vitamin E [4], which act as antioxidants [5], strengthen the immune system, protects the skin cells from toxins and ultra violet radiation [6] stimulate rapid recovery from induced heart attack [7], and has anti-cancer properties [8]. They also have a nephroprotective action against lipidinduced chronic renal dysfunction in rats [9].…”

Section: Introductionmentioning

confidence: 99%

Renal Function Indices are Distorted by Chronic Consumption of Thermoxidised Palm Oil

Beshel¹,

Beshel²,

Imade³

2019

SJMPS

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Fresh palm oil is known to compose of vitamin A and E; two well known antioxidants which combat alot of ailments caused by reactive oxygen species. Thermoxidized palm oil on the other hand has deleterious effects on some organs. This study was done to find out the effects of chronic consumption of palm oil on some renal function indices (protein, glucose and creatinine) in rats. Thirty male albino rats (weighing 140g-160g) of the wistar strain were randomly divided into three groups of ten rats each namely: control; (fed normal rat chow), FPO (fed 15%w/w fresh palm oil diets) and TPO (fed 15%w/w thermoxidized palm oil diets). All groups had free access to tap water. Results showed that plasma protein levels in TPO-fed animals were significantly (P<0.001) higher compared with control and FPO-fed groups. Creatinine levels were significantly (P<0.001) higher in TPO-fed group than those of the control and FPO-fed groups. Urine protein, glucose and creatinine levels in the TPO-fed group were significantly (P<0.001) higher than those of control and FPO groups. Conclusion: Chronic consumption of thermoxidized palm oil distorts renal handling of protein, glucose and Creatinine, while fresh palm oil maintains these renal function indices.

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“…It has been reported that cows fed with tallow showed higher total cholesterol in plasma than cows fed a low-fat diet [65]. Moreover, 21% tallow with 1.25% cholesterol consumption for six weeks led to renal dysfunction and atherosclerosis in the rats [66]. In addition, a beef tallow diet promoted body fat accumulation and reduced norepinephrine turnover rate in brown adipose tissue by reducing sympathetic activity [67].…”

Section: Discussionmentioning

confidence: 99%

Dillenia indica fruit extract has Glucose and Cholesterol Lowering effects

Khan

Bhowmik

Rhaman

et al. 2019

Preprint

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27 Background: Dillenia indica (D. indica) can suppress carbohydrates 28 hydrolysis by inhibiting α-amylase and α-glucosidase. However, there is a lack 29 of understanding of its therapeutic potential as an antidiabetic and anti-30 hyperlipidemic agent. 31Methods and findings: Type 2 diabetes (T2D) was induced by a single 32 intraperitoneal injection of Streptozotocin (STZ; 90mg/kg) and hyperlipidemia 33 by feeding with 1% cholesterol, 5% coconut oil and 5% cow fat diet. 34Administration of D. indica extracts in water for four weeks triggered a 35 significant (p≤0.05) reduction in fasting serum glucose (FSG) levels with 36 concomitant improvement in serum insulin levels. Both the water-and 37 ethanol-extract of D. indica treated groups showed significant (p≤0.01) 38 reduction in total cholesterol levels by 25% and 19%, respectively. HDL-39 cholesterol was also augmented (by 14%) in ethanol-extract treated group. 40Liver glycogen content was higher in the water-extract treated group. 41Histopathological examination revealed that there was no tubular epithelial 42 cell degeneration or necrosis in the renal tissues or hepatocyte degeneration 43 and sinusoidal dilation in liver tissues in animals that received the water-44 extract. On the other hand, consumption of D. indica extract with 1% 45 cholesterol, 5% coconut oil diet or with a 5% cow fat diet for 14 days 46 significantly reduced serum cholesterol levels in group-lll (60→45 mg/dl; 47 p≥0.05) and -IV (85→66 mg/dl; p≥0.05) hypercholesterolemic model rats. D. 48 indica fruit extract also reduced serum TG levels (Group-III: 87→65 mg/dl; 49 Group-IV: 40→90 mg/dl; p≥0.05). Interestingly, treatment with D. indica Page 3 of 52 50 prevented a reduction in serum HDL levels in those hypercholesterolemic 51 model rats. Serum LDL levels were significantly lower in group-III (47→39 52 mg/dl; p≥0.05) and group-IV (57→44 mg/dl; p≥0.05) hypercholesterolemic 53 model rats after D. indica treatment. 54 Conclusion: D. indica fruit ameliorates FSG, insulin secretion, glycogen 55 synthesis, and serum lipid profile. Therefore, D. indica fruit can be a potential 56 therapeutic agent for diabetic and hyperlipidemia. Introduction 75 Diabetes mellitus is a chronic metabolic disorder characterized by on-going 76 hyperglycemia. Insulin resistance and decreased insulin secretion are the two 77 cardinal features of type 2 diabetes mellitus (T2DM). T2DM is typically 78 diagnosed based on glucose levels, either a fasting plasma glucose (FPG) ≥ 79 7.0 or a 2-hour 75 g oral glucose tolerance test (OGTT) ≥ 11.1 mmol/L levels. 80 Pre-diabetic classifications include a fasting blood glucose (FBG) of 5.6-81 6.9 mmol/L or a 2-hour blood glucose level of ≥7.8 and < 11.1 mmol/L [1]. 82 T2DM is often accompanied by cardiovascular disease, diabetic neuropathy, 83 nephropathy, and retinopathy. An altered lipid profile is common in T2DM 84 patients. Furthermore, reduced hepatic glycogen storage is also observed in 85 diabetes [2-4]. Advancements in the modern lifestyle over the last century 86 have contr...

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Tocotrienols have a nephroprotective action against lipid-induced chronic renal dysfunction in rats

Cited by 23 publications

References 31 publications

Antioxidant capacity, physicochemical properties, thermal behavior, and oxidative stability of nectarine (Prunus persica var. nucipersica) kernel oil

Antioxidant capacity, physicochemical properties, thermal behavior, and oxidative stability of nectarine (Prunus persica var. nucipersica) kernel oil

Renal Function Indices are Distorted by Chronic Consumption of Thermoxidised Palm Oil

Dillenia indica fruit extract has Glucose and Cholesterol Lowering effects

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