Tocotrienol alleviates inflammation and oxidative stress in a rat model of spinal cord injury via suppression of transforming growth factor-β

Xun, Chuanhui; Mamat, Mardan; Guo, Hailong; Mamati, Pulat; Sheng, Jun; Zhang, Jian; Xu, Tao; Li, Weidong; Cao, Rui; Sheng, Weibin

doi:10.3892/etm.2017.4505

Cited by 18 publications

(16 citation statements)

References 37 publications

(50 reference statements)

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“…Similarly, T3 have been reported to inhibit the activity of TGF-β in human intestinal fibroblasts from Crohn’s disease patients and healthy controls [ 35 ] as well as the expression of TGF-β in the kidney of diabetic rats [ 75 ] and the transduction of TGF signaling in human prostate cancer cell lines [ 5 ]. Additional evidence of the inhibitory effect of T3 on TGF-β signaling has been reported in a rat model of spinal cord injury [ 91 ] and in human airway smooth muscle cells [ 17 ]. Anyway, more studies are needed to verify whether T3 may delay cellular senescence by targeting TGF-β signaling.…”

Section: Inhibition Of Cellular Senescence and Inflammation As Main Mmentioning

confidence: 88%

Anti-inflammatory Activity of Tocotrienols in Age-related Pathologies: A SASPected Involvement of Cellular Senescence

et al. 2018

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Tocotrienols (T3) have been shown to represent a very important part of the vitamin E family since they have opened new opportunities to prevent or treat a multitude of age-related chronic diseases. The beneficial effects of T3 include the amelioration of lipid profile, the promotion of Nrf2 mediated cytoprotective activity and the suppression of inflammation. All these effects may be the consequence of the ability of T3 to target multiple pathways. We here propose that these effects may be the result of a single target of T3, namely senescent cells. Indeed, T3 may act by a direct suppression of the senescence-associated secretory phenotype (SASP) produced by senescent cells, mediated by inhibition of NF-kB and mTOR, or may potentially remove the origin of the SASP trough senolysis (selective death of senescent cells). Further studies addressed to investigate the impact of T3 on cellular senescence “in vitro” as well as in experimental models of age-related diseases “in vivo” are clearly encouraged.

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Section: Inhibition Of Cellular Senescence and Inflammation As Main Mmentioning

confidence: 88%

Anti-inflammatory Activity of Tocotrienols in Age-related Pathologies: A SASPected Involvement of Cellular Senescence

et al. 2018

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“…Medicinal plants have been used for thousands of years. Herbs, roots, bulbs, and fruits contain different compounds which act as therapeutic ingredients [ 38 ]. Recently, traditional medicine has been the focus of attention in the treatment of some diseases, including SCI [ 39 ].…”

Section: Effects Of Natural Antioxidant Compounds On Scimentioning

confidence: 99%

“…Also, treatment with tocotrienols suppressed TGF- β , collagen type IV, and fibronectin protein expression levels. Furthermore, the BBB scores in rats treated with 120 mg/kg/day tocotrienol were significantly higher when compared with the group administered with MPS sodium succinate [ 38 ].…”

Section: Effects Of Natural Antioxidant Compounds On Scimentioning

confidence: 99%

The Importance of Natural Antioxidants in the Treatment of Spinal Cord Injury in Animal Models: An Overview

Coyoy-Salgado

Segura-Uribe

Guerra‐Araiza

et al. 2019

Oxidative Medicine and Cellular Longevity

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Patients with spinal cord injury (SCI) face devastating health, social, and financial consequences, as well as their families and caregivers. Reducing the levels of reactive oxygen species (ROS) and oxidative stress are essential strategies for SCI treatment. Some compounds from traditional medicine could be useful to decrease ROS generated after SCI. This review is aimed at highlighting the importance of some natural compounds with antioxidant capacity used in traditional medicine to treat traumatic SCI. An electronic search of published articles describing animal models of SCI treated with natural compounds from traditional medicine was conducted using the following terms: Spinal Cord Injuries (MeSH terms) AND Models, Animal (MeSH terms) AND [Reactive Oxygen Species (MeSH terms) AND/OR Oxidative Stress (MeSH term)] AND Medicine, Traditional (MeSH terms). Articles reported from 2010 to 2018 were included. The results were further screened by title and abstract for studies performed in rats, mice, and nonhuman primates. The effects of these natural compounds are discussed, including their antioxidant, anti-inflammatory, and antiapoptotic properties. Moreover, the antioxidant properties of natural compounds were emphasized since oxidative stress has a fundamental role in the generation and progression of several pathologies of the nervous system. The use of these compounds diminishes toxic effects due to their high antioxidant capacity. These compounds have been tested in animal models with promising results; however, no clinical studies have been conducted in humans. Further research of these natural compounds is crucial to a better understanding of their effects in patients with SCI.

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“…The inflammation includes increased expression of pro-inflammatory factors, including tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and a reduction in inflammatory mediators (8). The oxidative stress involves an increase in the levels of nitric oxide (NO) and reactive oxygen species (ROS) (9).…”

Section: Introductionmentioning

confidence: 99%

Low‑frequency pulsed electromagnetic field promotes functional recovery, reduces inflammation and oxidative stress, and enhances HSP70 expression following spinal cord injury

et al. 2019

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Low-frequency pulsed electromagnetic fields (LPEMFs) have been reported to be protective for multiple diseases. However, whether the administration of LPEMFs inhibits inflammation and oxidative stress following spinal cord injury requires further investigation. In the current study, a contusion spinal cord injury model was used and LPEMFs administration was applied to investigate the molecular changes, including inflammation, oxidative stress and heat shock protein 70 (HSP70) levels. The results revealed that LPEMFs significantly promoted functional recovery following spinal cord injury, as demonstrated by an increased Basso, Beattie and Bresnahan score. The results demonstrated that LPEMFs decreased the expression of inflammatory factors, including tumor necrosis factor-α, interleukin-1β and nuclear factor-κB. Additionally, LPEMFs exposure reduced the levels of inducible nitric oxide synthase and reactive oxygen species, and upregulated the expression of catalase and superoxide dismutase. Furthermore, treatment with LPEMFs significantly enhanced the expression of HSP70 in spinal cord-injured rats. Overall, the present study revealed that LPEMFs promote functional recovery following spinal cord injury, potentially by modulating inflammation, oxidative stress and HSP70.

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Tocotrienol alleviates inflammation and oxidative stress in a rat model of spinal cord injury via suppression of transforming growth factor-β

Cited by 18 publications

References 37 publications

Anti-inflammatory Activity of Tocotrienols in Age-related Pathologies: A SASPected Involvement of Cellular Senescence

Anti-inflammatory Activity of Tocotrienols in Age-related Pathologies: A SASPected Involvement of Cellular Senescence

The Importance of Natural Antioxidants in the Treatment of Spinal Cord Injury in Animal Models: An Overview

Low‑frequency pulsed electromagnetic field promotes functional recovery, reduces inflammation and oxidative stress, and enhances HSP70 expression following spinal cord injury

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