Tobramycin-resistant small colony variant mutant of
Salmonella enterica
serovar Typhimurium shows collateral sensitivity to nitrofurantoin
Chang-Zhen Wang,
Yue-Jun Zhang,
Yue-Fei Chu
et al.
Abstract:The increasing antibiotic resistance poses a significant global health challenge, threatening our ability to combat infectious diseases. The phenomenon of collateral sensitivity, whereby resistance to one antibiotic is accompanied by increased sensitivity to another, offers potential avenues for novel therapeutic interventions against infections unresponsive to classical treatments. In this study, we elucidate the emergence of tobramycin (TOB)-resistant small colony variants (SCVs) due to mutations in the
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