Tobamoviruses can be frequently present in the oropharynx and gut of infants during their first year of life

Aguado-García, Yarenci; Taboada, Blanca; Morán, Patricia; Rivera-Gutiérrez, Xaira; Serrano-Vázquez, Angélica; Iša, Pavel; Rojas-Velázquez, Liliana; Pérez-Juárez, Horacio; López, Susana; Torres, Javier; Ximénez, Cecilia; Arias, Carlos F.

doi:10.1038/s41598-020-70684-w

Cited by 20 publications

(23 citation statements)

References 26 publications

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“…reads per sample, respectively. A detailed characterization of the plant viruses found in the infants' gut was recently reported by our group [42].…”

Section: Plos Onementioning

confidence: 89%

“…Our results showed a large diversity of tobamoviruses circulating in the population, suggesting that infants are continuously exposed to an extensive and dynamic collection of these plant viruses, even before infants begin to ingest food other than mother's breastmilk, including baby formula or other liquids, indicating a distinct source of origin for these viruses. We recently reported the genetic diversity and dynamics of tobamovirus infection in infants, as wells as the potential implications of these findings [42].…”

Section: Plos Onementioning

confidence: 99%

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The gut virome of healthy children during the first year of life is diverse and dynamic

et al. 2021

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In this work, we determined the diversity and dynamics of the gut virome of infants during the first year of life. Fecal samples were collected monthly, from birth to one year of age, from three healthy children living in a semi-rural village in Mexico. Most of the viral reads were classified into six families of bacteriophages including five dsDNA virus families of the order Caudovirales, with Siphoviridae and Podoviridae being the most abundant. Eukaryotic viruses were detected as early as two weeks after birth and remained present all along the first year of life. Thirty-four different eukaryotic virus families were found, where eight of these families accounted for 98% of all eukaryotic viral reads: Anelloviridae, Astroviridae, Caliciviridae, Genomoviridae, Parvoviridae, Picornaviridae, Reoviridae and the plant-infecting viruses of the Virgaviridae family. Some viruses in these families are known human pathogens, and it is surprising that they were found during the first year of life in infants without gastrointestinal symptoms. The eukaryotic virus species richness found in this work was higher than that observed in previous studies; on average between 7 and 24 virus species were identified per sample. The richness and abundance of the eukaryotic virome significantly increased during the second semester of life, probably because of an increased environmental exposure of infants with age. Our findings suggest an early and permanent contact of infants with a diverse array of bacteriophages and eukaryotic viruses, whose composition changes over time. The bacteriophages and eukaryotic viruses found in these children could represent a metastable virome, whose potential influence on the development of the infant’s immune system or on the health of the infants later in life, remains to be investigated.

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“…reads per sample, respectively. A detailed characterization of the plant viruses found in the infants' gut was recently reported by our group [42].…”

Section: Plos Onementioning

confidence: 89%

Section: Plos Onementioning

confidence: 99%

The gut virome of healthy children during the first year of life is diverse and dynamic

et al. 2021

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“…The sources of contamination can be manifold, including viruses contaminating the laboratory reagents (Naccache et al., 2013) and human viruses present in the laboratory personnel. In this respect, it is interesting to note that plant‐infecting viruses, including TSAMV, are frequently found in the human oropharynx and gut as a result of plant consumption (Aguado‐García et al., 2020; Balique et al., 2015), which may suggest a possible source of contamination.…”

Section: Resultsmentioning

confidence: 99%

A vertically transmitted amalgavirus is present in certain accessions of the bryophyte Physcomitrium patens

et al. 2021

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In the last few years, next-generation sequencing techniques have started to be used to identify new viruses infecting plants. This has allowed to rapidly increase our knowledge on viruses other than those causing symptoms in economically important crops. Here we used this approach to identify a virus infecting Physcomitrium patens that has the typical structure of the double-stranded RNA endogenous viruses of the Amalgaviridae family, which we named Physcomitrium patens amalgavirus 1, or PHPAV1. PHPAV1 is present only in certain accessions of P. patens, where its RNA can be detected throughout the cell cycle of the plant. Our analysis demonstrates that PHPAV1 can be vertically transmitted through both paternal and maternal germlines, in crosses between accessions that contain the virus with accessions that do not contain it. This work suggests that PHPAV1 can replicate in genomic backgrounds different from those that actually contain the virus and opens the door for future studies on virus-host coevolution.

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“…This indicates that control at farm level may at least partially mitigate the risks posed [ 10 ]. Currently, there is no evidence for negative impacts of plants affected by plant viruses on human health [ 11 ], although there is potential for them to have negative impacts on ecosystem functioning [ 12 ]. There is a need for early identification of emerging agricultural and food risks in order to prevent them from resulting in negative health, environmental or economic impacts, and to ensure emerging risk identification can be embedded in the risk analysis process for food safety [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Risk perception associated with an emerging agri-food risk in Europe: plant viruses in agriculture

et al. 2022

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Background Research into public risk perceptions associated with emerging risks in agriculture and supply chains has focused on technological risks, zoonotic diseases, and food integrity, but infrequently on naturally occurring diseases in plants. Plant virus infections account for global economic losses estimated at $30 billion annually and are responsible for nearly 50% of plant diseases worldwide, threatening global food security. This research aimed to understand public perceptions of emerging risks and benefits associated with plant viruses in agriculture in Belgium, Slovenia, Spain, and the UK. Methods Online qualitative semi-structured interviews with 80 European consumers were conducted, including 20 participants in each of Belgium, Slovenia, the UK, and Spain. Microsoft Streams was used to transcribe the interview data, and NVivo was utilized to code the transcripts and analyze the data. Results The results indicate that, while study participants were relatively unfamiliar with the plant viruses and their potential impacts, plant viruses evoked perceived risks in a similar way to other emerging risks in the agri-food sector. These included risks to environment and human health, and the economic functioning of the relevant supply chain. Some participants perceived both risks and benefits to be associated with plant viruses. Benefits were perceived to be associated with improved plant resistance to viruses. Conclusions The results provide the basis for risk regulation, policy, and communication developments. Risk communication needs to take account of both risk and benefit perceptions, as well as the observation that plant viruses are perceived as an emerging, rather than an established, understood, and controlled risk. Some participants indicated the need for risk–benefit communication strategies to be developed, including information about the impacts of the risks, and associated mitigation strategies. Participants perceived that responsibility for control of plant viruses should be conferred on actors within the supply chain, in particular primary producers, although policy support (for example, financial incentivization) should be provided to improve their motivation to instigate risk mitigation activities.

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Tobamoviruses can be frequently present in the oropharynx and gut of infants during their first year of life

Cited by 20 publications

References 26 publications

The gut virome of healthy children during the first year of life is diverse and dynamic

The gut virome of healthy children during the first year of life is diverse and dynamic

A vertically transmitted amalgavirus is present in certain accessions of the bryophyte Physcomitrium patens

Risk perception associated with an emerging agri-food risk in Europe: plant viruses in agriculture

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