Tobacco Use and Cessation in HIV-Infected Individuals

Browning, Kristine K.; Wewers, Mary Ellen; Ferketich, Amy K.; Diaz, Philip T.

doi:10.1016/j.ccm.2013.01.005

Cited by 44 publications

(31 citation statements)

References 65 publications

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“…These include pulmonary complications, cancer, cardiovascular disease, fragility fractures and impaired immune response to antiretroviral therapy[32, 25, 33–37, 30]. Most important is the impact of smoking on mortality.…”

Section: Tobaccomentioning

confidence: 99%

“…Data from the general population demonstrate that benefits of quitting smoking are evident regardless of age[41]. While effective treatment strategies in the general population and older populations specifically integrate counseling and pharmacotherapy[42–44], there have been only a limited number of treatment trials in HIV-infected populations[32, 45–49]. A large-scale trial compared the efficacy of a cell phone counseling-based smoking cessation intervention which occurred over 3 months plus access to a hotline to treatment as usual targeting a HIV-infected population (n=474).…”

Section: Tobaccomentioning

confidence: 99%

“…The data on the efficacy and safety of pharmacotherapy for tobacco dependence in the setting of antiretroviral agents and in HIV-infected patients are currently limited[52, 32, 53]. A recent preliminary non-randomized 12-week study in which all participants received telephone counseling and either varenicline or nicotine replacement therapy found that varenicline was associated with a greater odds of abstinence compared with nicotine replacement therapy.…”

Section: Tobaccomentioning

confidence: 99%

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Substance use in older HIV-infected patients

Edelman¹,

Tetrault²,

Fiellin³

2014

Current Opinion in HIV and AIDS

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Purpose of the Review Substance use may persist throughout the life course and has a substantial impact on health outcomes globally. As HIV-infected individuals are disproportionately impacted by substance use and living longer, it is critical that providers and researchers alike understand the impact of substance use on older, HIV-infected patients and potential treatment options. To this end, we conducted a review of the literature focusing on the most commonly used substances to outline the epidemiology, health consequences, treatment options and latest research relevant to older, HIV-infected patients. Recent Findings Substance use impacts older, HIV-infected patients with regards to HIV-related and non-HIV related outcomes. Counseling strategies are available for marijuana and stimulant use disorders. Brief counseling is useful alongside medications for alcohol, tobacco and opioid use disorders. Many medications for alcohol, tobacco, and opioid use disorders are safe in the setting of antiretroviral therapy. Unfortunately, few interventions targeting substance use in older, HIV-infected patients have been developed and evaluated. Summary As older, HIV-infected patients continue to experience substance use and its related health consequences, there will be a growing need for the development of safe and effective interventions which address the complex needs of this population.

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Section: Tobaccomentioning

confidence: 99%

Section: Tobaccomentioning

confidence: 99%

Section: Tobaccomentioning

confidence: 99%

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Substance use in older HIV-infected patients

Edelman¹,

Tetrault²,

Fiellin³

2014

Current Opinion in HIV and AIDS

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“…However, while mortality from AIDS and other causes may result in reduced survival for HIV-infected individuals, few studies have examined cancer-specific mortality (16); furthermore, several were conducted among individuals living with AIDS, (13,14) who are at particularly high risk of death from non-cancer causes. Despite differences by HIV status in mortality risk factors, such as smoking (19,20) and cancer treatment (21,22), few studies have had available data or adequate sample size to adjust for these factors in analyses of individual cancers. (16,17) Finally, cancers may be diagnosed at a more advanced stage or earlier age among HIV-infected individuals; (23,24) although most studies of cancer prognosis have adjusted for age at diagnosis, few have adjusted for stage in analyses of individual cancers.…”

Section: Introductionmentioning

confidence: 99%

Survival among HIV-Infected and HIV-Uninfected Individuals with Common Non–AIDS-Defining Cancers

Marcus

Chao

Leyden

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

100

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Background Non-AIDS-defining cancers increasingly contribute to mortality among human immunodeficiency virus (HIV)-infected individuals. However, few studies have compared cancer prognosis by HIV status with adjustment for risk factors. Methods We conducted a cohort study of HIV-infected and HIV-uninfected adults in Kaiser Permanente California during 1996–2011, following subjects diagnosed with Hodgkin lymphoma (HL) or anal, prostate, colorectal, or lung cancers. We used Kaplan-Meier curves and Cox regression to assess cancer-related mortality within five years, comparing HIV-infected with HIV-uninfected subjects. Adjusted models included age, race/ethnicity, sex, cancer stage, cancer treatment, and smoking. Results Among HIV-infected and HIV-uninfected subjects, there were 68 and 51 cases of HL, 120 and 28 of anal cancer, 150 and 2050 of prostate cancer, 53 and 646 of colorectal cancer, and 80 and 507 of lung cancer, respectively. Five-year cancer-related survival was reduced for HIV-infected compared with HIV-uninfected subjects, reaching statistical significance for lung cancer (10% vs. 19%, P=0.002) but not HL (83% vs. 89%, P=0.40) or anal (64% vs. 74%, P=0.38), prostate (86% vs. 92%, P=0.074), or colorectal cancers (49% vs. 58%, P=0.55). Adjusted results were similar, with lung cancer (hazard ratio [HR] 1.3, 95% confidence interval [CI]: 1.0–1.7) and prostate cancer (HR 2.1, 95% CI: 1.1–4.1) reaching significance. Conclusions Cancer-related mortality was higher among HIV-infected compared with HIV-uninfected individuals for prostate and lung cancers, but not HL, anal cancer, or colorectal cancer. Impact Our findings emphasize the need for a focus on prevention, early detection, and adequate treatment of cancer among HIV-infected individuals.

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“…Compared to the general population, PLWH are far more likely to be current smokers (Browning et al, 2013) and, subsequently, are confronted with numerous tobacco- and HIV-related health risks (Feldman and Anderson, 2013; Palella and Phair, 2011; Smith et al, 2010). In fact, PLWH who smoke cigarettes are at higher risk for acute bronchitis, bacterial pneumonia, pulmonary disease, non-AIDS and AIDS-defining cancers, and overall mortality (Burke et al, 2004; Crothers et al, 2005; Engels et al, 2006; Lifson et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Mediators of a smoking cessation intervention for persons living with HIV/AIDS

Vidrine

Kypriotakis

et al. 2015

Drug and Alcohol Dependence

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Background Cigarette smoking among persons living with HIV (PLWH) is a pressing public health concern, and efforts to evaluate cessation treatments are needed. The purpose of the present study was to assess potential mechanisms of a cell phone-delivered intervention for HIV-positive smokers. Methods Data from 350 PLWH enrolled in a randomized smoking cessation treatment trial were utilized. Participants were randomized to either usual care (UC) or a cell phone intervention (CPI) group. The independent variable of interest was treatment group membership, while the dependent variable of interest was smoking abstinence at a 3-month follow-up. The hypothesized treatment mechanisms were depression, anxiety, social support, quit motivation and self-efficacy change scores. Results Abstinence rates in the UC and CPI groups were 4.7% (8 of 172) and 15.7% (28 of 178), respectively. The CPI group (vs. UC) experienced a larger decline in depression between baseline and the 3-month follow-up, and a decline in anxiety. Self-efficacy increased for the CPI group and declined for the UC group. Quit motivation and social support change scores did not differ by treatment group. Only self-efficacy met the predefined criteria for mediation. The effect of the cell phone intervention on smoking abstinence through change in self-efficacy was statistically significant (p<.001) and accounted for 17% of the total effect of the intervention on abstinence. Conclusions The findings further emphasize the important mechanistic function of self-efficacy in promoting smoking cessation for PLWH. Additional efforts are required to disentangle the relationships between emotional, distress motivation, and efficacious smoking cessation treatment.

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Tobacco Use and Cessation in HIV-Infected Individuals

Cited by 44 publications

References 65 publications

Substance use in older HIV-infected patients

Substance use in older HIV-infected patients

Survival among HIV-Infected and HIV-Uninfected Individuals with Common Non–AIDS-Defining Cancers

Mediators of a smoking cessation intervention for persons living with HIV/AIDS

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