Tobacco usage interacts with postdisaster psychopathology on circadian salivary cortisol

Olff, Miranda; Meewisse, Marie-Louise; Kleber, Rolf J.; Velden, Peter G. van der; Drogendijk, Annelieke N.; Amsterdam, Jan van; Opperhuizen, Antoon; Gersons, Berthold P. R.

doi:10.1016/j.ijpsycho.2005.10.014

Cited by 33 publications

(16 citation statements)

References 56 publications

(54 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cortisol levels are also affected by smoking [41-43]. We did not take smoking habits into account in this study, but it should be in future studies.…”

Section: Discussionmentioning

confidence: 99%

Impulsivity and Saliva Cortisol in Patients with Suicide Attempt and Controls

et al. 2017

View full text Add to dashboard Cite

Objectives: The objective of this study was to prove concepts in the characterization of suicidal patients and the possible usefulness of those markers to potentially identify patients with a higher risk for suicidality. Methods: Patients with a recent suicide attempt were compared with patients suffering from depression, adjustment disorder, anxiety, or eating disorders without suicidality, healthy controls and remitted patients with a history of at least 1 suicide attempt (≥1 year). We analyzed impulsivity (Barratt Impulsivity Scale, BIS) and saliva cortisol concentrations. Results: Independently of suicidality and disease state patients display higher BIS scores than healthy controls. Saliva cortisol levels tend to be higher in patients in the acute disease state than in remitted patients and healthy controls. Conclusions: Saliva cortisol may be a useful marker that reveals alterations in nonsuicidal patients suffering from depression, adjustment disorder, anxiety, or eating disorders who might be at risk.

show abstract

“…Cortisol levels are also affected by smoking [41-43]. We did not take smoking habits into account in this study, but it should be in future studies.…”

Section: Discussionmentioning

confidence: 99%

Impulsivity and Saliva Cortisol in Patients with Suicide Attempt and Controls

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Alternately, pain, alcohol and opiate drug use were found to increase the cortisol response to acute stress (Coventry et al, 2001;Ehring et al, 2008;Stankiewicz et al, 2013). Furthermore, studies have shown that smoking is an independent risk factor for mental health problems in a post-disaster sample (Olff et al, 2006;van der Velden et al, 2007), and pain moderates the relationship between cortisol and the development of PTSD in a sample of injury victims (Ehring et al, 2008). Since we had no information about these variables, we do not know whether they may have influenced the association between cortisol level and PTSD symptoms.…”

Section: Discussionmentioning

confidence: 99%

The role of acute cortisol and DHEAS in predicting acute and chronic PTSD symptoms

Mouthaan

Sijbrandij²,

Luitse

et al. 2014

Psychoneuroendocrinology

Self Cite

View full text Add to dashboard Cite

SummaryBackground: Decreased activation of the hypothalamus-pituitary-adrenal (HPA) axis in response to stress is suspected to be a vulnerability factor for posttraumatic stress disorder (PTSD). Previous studies showed inconsistent findings regarding the role of cortisol in predicting PTSD. In addition, no prospective studies have examined the role of dehydroepiandrosterone (DHEA), or its sulfate form DHEAS, and the cortisol-to-DHEA(S) ratio in predicting PTSD. In this study, we tested whether acute plasma cortisol, DHEAS and the cortisol-to-DHEAS ratio predicted PTSD symptoms at 6 weeks and 6 months post-trauma. Methods: Blood samples of 397 adult level-1 trauma center patients, taken at the trauma resuscitation room within hours after the injury, were analyzed for cortisol and DHEAS levels. PTSD symptoms were assessed at 6 weeks and 6 months post-trauma with the Clinician Administered PTSD Scale. Results: Multivariate linear regression analyses showed that lower cortisol predicted PTSD symptoms at both 6 weeks and 6 months, controlling for age, gender, time of blood sampling, injury, trauma history, and admission to intensive care. Higher DHEAS and a smaller cortisol-to-DHEAS ratio predicted PTSD symptoms at 6 weeks, but not after controlling for the same variables, and not at 6 months. Conclusions: Our study provides important new evidence on the crucial role of the HPA-axis in response to trauma by showing that acute cortisol and DHEAS levels predict PTSD symptoms in survivors of recent trauma. #

show abstract

“…An additional weakness of the study is the absence of information on cigarette smoking. Tobacco use elevates cortisol levels (Steptoe & Ussher, 2006), and may interact with posttraumatic major depression to affect HPA axis parameters (Olff et al, 2006b). Although the distribution of depression did not differ between responder and non-responder groups, tobacco use may have been a relevant covariate and should be examined in future studies.…”

Section: Discussionmentioning

confidence: 99%

Cortisol metabolic predictors of response to psychotherapy for symptoms of PTSD in survivors of the World Trade Center attacks on September 11, 2001

Yehuda

Bierer

Sarapas

et al. 2009

Psychoneuroendocrinology

View full text Add to dashboard Cite

Background A proportion of subjects with symptoms of posttraumatic stress disorder (PTSD) are unresponsive to specialized psychotherapy, but a biological basis for this has not been described. To observe whether differences in cortisol or its metabolites predict or correlate with response to therapy for PTSD symptoms, cortisol and its metabolites were measured from urine samples at pre-treatment, at the conclusion of psychotherapy, and at 3-month follow-up. Methods 28 survivors of the World Trade Center attack on September 11, 2001 seeking psychological treatment for PTSD symptoms received four sessions of either exposure therapy or supportive counseling, followed by up to 10 sessions of prolonged exposure in a specialized PTSD treatment program at a private hospital serving the New York City metropolitan area. 24-hr mean integrated cortisol excretion was assessed by radioimmunoassay (RIA); urinary free cortisol and metabolites cortisone, 5α–tetrahydrocortisol (5α-THF), 5β–tetrahydrocortisol, and tetrahydrocortisone were assessed by gas chromatography-mass spectrometry (GCMS); and indices of enzyme activities for 5α–and 5β–reductase and for the 11β–hydroxysteroid dehydrogenases were derived from the metabolite and glucocorticoid measures. Results 5α-reductase activity was significantly lower at pre-treatment among non-responders, whereas there were no significant pre-treatment differences between responders and non-responders in any other hormone or metabolite level. In repeated-measures analyses across the three time points, 5α-reductase activity, as well as 5α-THF and total glucocorticoids, significantly differed between responders and non-responders. For urinary cortisol measured by RIA, there was a significant group × time interaction indicating that, although not different at pre-treatment, urinary cortisol levels declined over time in the non-responder group, such that by follow-up, lowered cortisol significantly distinguished non-responders from responders. Indices of 5α-reductase activity, including 5α-THF and total glucocorticoids, were significantly negatively correlated with avoidance symptom severity at pre-treatment. At follow-up, indices of 5α-reductase activity were significantly negatively correlated with severity of all three PTSD symptom clusters and with total PTSD severity scores. Conclusion Lower 5α–reductase activity is associated with avoidance severity and predicts non-responsiveness to psychological treatment for PTSD symptomatology. Relatively diminished 5α–reductase activity may mark a state of primary vulnerability, perhaps via attenuated peripheral catabolism of cortisol resulting in the suppression of hypothalamic-pituitary-adrenal axis responsiveness. Lower cortisol levels appear later in the progression to chronic, treatment-resistant PTSD.

show abstract

Tobacco usage interacts with postdisaster psychopathology on circadian salivary cortisol

Cited by 33 publications

References 56 publications

Impulsivity and Saliva Cortisol in Patients with Suicide Attempt and Controls

Impulsivity and Saliva Cortisol in Patients with Suicide Attempt and Controls

The role of acute cortisol and DHEAS in predicting acute and chronic PTSD symptoms

Cortisol metabolic predictors of response to psychotherapy for symptoms of PTSD in survivors of the World Trade Center attacks on September 11, 2001

Contact Info

Product

Resources

About