Tobacco Tar Components That Stimulate Nerve Growth Factor (NGF) Synthesis/Secretion of Mouse Astroglial Cells in Culture

Murase, Kouhei; Shimizu, Yuma; Hayashi, Kyozo

doi:10.1271/bbb.58.900

Cited by 5 publications

(5 citation statements)

References 8 publications

(11 reference statements)

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“…Consistent with our findings, hericenones C, D, and E (10 mg/ mL) which were isolated from the fruiting body of Hericium erinaceus mushroom were able to stimulate the production of NGF to 100-319 pg/mL [21]. Nicotine, p-hydroquinones, 4methylcatechol were also identified as potent stimulators of NGF synthesis in vitro [22]. Notably, 4-methylcatechol was found to induce an increase in NGF in the adult rat heart and submaxillary gland [23].…”

Section: Discussionsupporting

confidence: 89%

Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells

et al. 2016

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Negletein has been shown to have therapeutic potential for inflammation-associated diseases, but its effect on neurite outgrowth is still unknown. The present study showed that negletein alone did not trigger PC12 cells to differentiate and extend neurites. When compared with the cells in the untreated control, a significant (P < 0.05) induction and a higher neurite outgrowth activity was observed when the cells were cotreated with negletein (10 µM) and a low dose of nerve growth factor (NGF; 5 ng/mL). The neurite outgrowth process was blocked by the tyrosine kinase receptor (Trk) inhibitor, K252a, suggesting that the neuritogenic effect was NGF-dependent. Negletein (10 µM) together with NGF (5 ng/mL) enhanced the phosphorylation of extracellular signal-regulated kinases (ERKs), protein kinase B (Akt), and cAMP response element-binding protein (CREB). The growth associated protein-43 (GAP-43) and the NGF level were also upregulated by negletein (10 µM) and a low dose of NGF (5 ng/mL). Negletein at nanomolar concentration also was found to be sufficient to mediate the survival of serum-deprived PC12 cells up to 72 h. Taken together, negletein might be useful as an efficient bioactive compound to protect neurons from cell death and promote neuritogenesis. © 2016 BioFactors, 42(6):591-599, 2016.

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Section: Discussionsupporting

confidence: 89%

Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells

et al. 2016

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“…Furthermore, fructose, which is increased due to the activation of the polyol pathway, leads to the formation of AGE precursors [73] ( Figure 2). Alpha-lipoic acid has additional actions such as stimulating nerve growth factor and promoting fiber regeneration [74,75].…”

Section: Oxidative Stress and Alpha-lipoic Acidmentioning

confidence: 99%

Alpha-Lipoic Acid and Diabetic Neuropathy

Vallianou¹,

Evangelopoulos²,

Koutalas³

2009

Rev Diabet Stud

109

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Diabetic neuropathy presents a major public health problem. It is defined by the symptoms and signs of peripheral nerve dysfunction in diabetic patients, in whom other causes of neuropathy have been excluded. Pathogenetic mechanisms that have been implicated in diabetic neuropathy are: a) increased flux through the polyol pathway, leading to accumulation of sorbitol, a reduction in myo-inositol, and an associated reduced Na+-K+-ATPase activity, and b) endoneurial microvascular damage and hypoxia due to nitric oxide inactivation by increased oxygen free radical activity. Alpha-lipoic acid seems to delay or reverse peripheral diabetic neuropathy through its multiple antioxidant properties. Treatment with alpha-lipoic acid increases reduced glutathione, an important endogenous antioxidant. In clinical trials, 600 mg alpha-lipoic acid has been shown to improve neuropathic deficits. This review focuses on the relationship of alpha-lipoic acid and auto-oxidative glycosylation. It discusses the impact of alpha-lipoic acid on hyperglycemia-induced oxidative stress, and examines the role of alpha-lipoic acid in preventing glycation process and nerve hypoxia.

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“…Second, studies suggest that PQQ supplementation enhances memory and cognitive performance, particularly in tasks related to memory and learning. These effects may be related to the promotion of nerve growth factor (NGF) production (35,36) and mitochondrial function (37). PQQ stimulates the production of NGF, an essential protein for the growth, maintenance, and repair of nerve cells (neurons), and PQQ supports mitochondria, including those in brain cells, by increasing PGC-1α gene expression, which is a transcriptional coactivator and central inducer of mitochondrial biogenesis.…”

Section: Molecular Mechanism Of Pqq Effectsmentioning

confidence: 99%

The effects of pyrroloquinoline quinone disodium salt on brain function and physiological processes

Ikemoto,

Mohamad Ishak,

Akagawa

2024

J. Med. Invest.

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Pyrroloquinoline quinone disodium salt (PQQ) is a red trihydrate crystal that was approved as a new food ingredient by FDA in 2008. Now, it is approved as a food in Japan and the EU. PQQ has redox properties and exerts antioxidant, neuroprotective, and mitochondrial biogenesis effects. The baseline intake level of PQQ is considered to be 20 mg / day. PQQ ingestion lowers blood lipid peroxide levels in humans, suggesting antioxidant activity. In the field of cognitive function, double-blind, placebo-controlled trials have been conducted. Various improvements have been reported regarding general memory, verbal memory, working memory, and attention. Furthermore, a stratified analysis of a population with a wide range of ages revealed unique effects in young people (20-40 years old) that were not observed in older adults (41-65 years old). Specifically, cognitive flexibility and executive speed improved more rapidly in young people at 8 weeks. Co-administration of PQQ and coenzyme Q10 further enhanced these effects. In an open-label trial, PQQ was shown to improve sleep and mood. Additionally, PQQ was found to suppress skin moisture loss and increase PGC-1α α expression. Overall, PQQ is a food with various functions, including brain health benefits.

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Tobacco Tar Components That Stimulate Nerve Growth Factor (NGF) Synthesis/Secretion of Mouse Astroglial Cells in Culture

Cited by 5 publications

References 8 publications

Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells

Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells

Alpha-Lipoic Acid and Diabetic Neuropathy

The effects of pyrroloquinoline quinone disodium salt on brain function and physiological processes

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