Tobacco smoking, occupational exposure and bladder cancer in Argentina

Iscovich, José; Castelletto, R; Estève, Jacques; Muñóz, Núbia; Colanzi, Rony; Coronel, Ana Fuentes; Deamezola, I; Tassi, Valter; Arslan, Annie

doi:10.1002/ijc.2910400604

Cited by 92 publications

(37 citation statements)

References 21 publications

(21 reference statements)

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“…11). On the other hand, several older studies have not found statistically significant increases in risk associated with familial history of cancer (7,9,(29)(30)(31)(32)(33).…”

Section: Discussionmentioning

confidence: 93%

Risk of Bladder Cancer Associated with Family History of Cancer: Do Low-Penetrance Polymorphisms Account for the Increase in Risk?

Murta-Nascimento

Silverman

Kogevinas

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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The relationship between family history of cancer in firstdegree relatives and risk of bladder cancer was examined in the Spanish Bladder Cancer Study. Information on family history of cancer was obtained for 1,158 newly diagnosed bladder cancer cases and 1,244 controls included in 18 hospitals between 1998 and 2001. A total of 464 (40.1%) cases and 436 (35.1%) controls reported a family history of cancer in z1 relative [odds ratio (OR), 1.32; 95% confidence interval (95% CI), 1.11-1.59]; the OR was 1.23 (95% CI, 1.01-1.50) among those with only one relative affected and 1.67 (95% CI, 1.23-2.29) among those with z2 affected relatives (P trend = 0.0004). A greater risk of bladder cancer was observed among those diagnosed at age V45 years (OR, 2.67; 95% CI, 1.10-6.50) compared with those diagnosed over age 45 years (OR, 1.27; 95% CI, 1.06-1.52). The OR of bladder cancer among subjects reporting a family history of cancer of the bladder was 2.34 (95% CI, 0.95-5.77). Statistically significant associations emerged between bladder cancer risk and family history of cancer of the esophagus, lung, prostate, and brain. The OR of bladder cancer for those reporting family history of bladder cancer was 4.76 (95% CI, 1.25-18.09) among NAT2-slow acetylators and 1.17 (95% CI, 0.17-7.86) among NAT2-rapid/ intermediate acetylators (P interaction = 0.609). Among individuals with GSTM1 null and present genotypes, the corresponding ORs were 2.91 (95% CI, 0.44-19.09) and 4.21 (95% CI, 1.26-14.14), respectively (P interaction = 0.712). Limitations of our study are small sample size in subgroup analyses, reliability of family history data, and possible residual confounding by shared environmental exposures. Overall, our findings support the hypothesis that genetic factors play a role in bladder cancer etiology. Whether these correspond to low-penetrance cancer-predisposing polymorphisms acting together and/or interacting with environmental factors warrants further research. (Cancer Epidemiol Biomarkers Prev 2007;16(8):1595 -600)

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“…11). On the other hand, several older studies have not found statistically significant increases in risk associated with familial history of cancer (7,9,(29)(30)(31)(32)(33).…”

Section: Discussionmentioning

confidence: 93%

Risk of Bladder Cancer Associated with Family History of Cancer: Do Low-Penetrance Polymorphisms Account for the Increase in Risk?

Murta-Nascimento

Silverman

Kogevinas

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

show abstract

“…Most previous studies reported either null associations 2,6,[17][18][19][20][21][22][23][24] or slightly positive associations 4,5,[25][26][27][28][29] between consumption of alcoholic beverages and risk of bladder cancer. Our results regarding beverage-specific consumption are in agreement with some, but not all, previous studies.…”

Section: Discussionmentioning

confidence: 99%

Alcohol consumption and risk of bladder cancer in Los Angeles County

Jiang

Castelao

Groshen

et al. 2007

Intl Journal of Cancer

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The role of alcoholic beverages in bladder carcinogenesis is still unclear, with conflicting evidence from different studies. We investigated the relationship between alcohol consumption and bladder cancer, and the potential interaction between alcohol consumption and other exposures. In a population-based case-control study conducted in Los Angeles County, 1,586 pairs of cases and their matched neighborhood controls were interviewed. Data were analyzed to determine whether bladder cancer risk differs by alcohol consumption, and whether different alcoholic beverages have different effects. The risk of bladder cancer decreased with increasing frequency (p for trend 5 0.003) and duration of alcohol consumption (p for trend 5 0.017). Subjects who drank more than 4 drinks per day had a 32% lower (odds ratio, 0.68; 95% confidence interval, 0.52-0.90) risk of bladder cancer than those who never drank any alcoholic beverage. Beer (p for trend 5 0.002) and wine (p for trend 5 0.054) consumption were associated with reduced risk of bladder cancer, while hard liquor was not. The reduction in risk was mostly seen among shorter-term smokers who urinated frequently. Alcohol consumption was strongly associated with a reduced risk of bladder cancer. The effect was modified by the type of alcoholic beverage, cigarette smoking and frequency of urination. ' 2007 Wiley-Liss, Inc.

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“…We found that the new age-and smoking-adjusted summary odds ratio was 1.35 (95 percent CI: 0.96, 1.91). Associations between specific alcoholic beverages and bladder cancer risk were reported in nine studies without consistent results (12)(13)(14)(15)(16)(17)(18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%

Alcohol Consumption and Bladder Cancer Risk: Results from the Netherlands Cohort Study

Volovics¹,

Dorant²,

Goldbohm³

et al. 2001

American Journal of Epidemiology

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Although several epidemiologic studies have been conducted on alcohol consumption and bladder cancer risk, the risk according to quantity and type of alcohol consumed is not clear. The authors investigated these associations in a large prospective cohort study on diet and cancer among 120,852 subjects in the Netherlands aged 55-69 years at baseline (1986). Subjects completed a questionnaire on risk factors for cancer, including alcohol consumption. Follow-up for incident cancer was established by record linkage to cancer registries. The case-cohort analysis was restricted to a follow-up period of 6.3 years and was based on 594 cases with bladder cancer and 3,170 subcohort members. The authors corrected for age and smoking in multivariable analyses. The incidence rate ratios for men who consumed <5, 5-<15, 15-<30, and ≥30 grams of alcohol per day were 1.49, 1.52, 1.16, and 1.63 compared with nondrinkers, respectively (p for trend = 0.13). Alcohol consumed from beer, wine, and liquor was associated with moderately elevated risks, although most were not statistically significant. The incidence rate ratios for women varied around unity. The results of this study do not suggest an important association between alcohol consumption and bladder cancer risk. Although several epidemiologic studies have been conducted to investigate the association between alcohol consumption and bladder cancer risk, the risk according to quantity and type of alcohol consumed is still not clear. In a recent meta-analysis of these studies, a slightly elevated risk of bladder cancer was demonstrated for men currently drinking alcohol compared with abstainers (1). In this metaanalysis, however, no data were available to explore the influence of quantity and types of alcoholic beverages consumed. These results prompted us to investigate these associations in more detail in the ongoing Netherlands Cohort Study. MATERIALS AND METHODS CohortThe study design has been described in detail previously (2). The study population originated from 204 municipal population registries throughout the Netherlands, and the cohort includes 58,279 men and 62,573 women who were aged 55-69 years at baseline (1986). We used the case-cohort approach for data processing and analysis (3). A subcohort of 3,500 subjects was randomly sampled from the cohort after baseline exposure measurement and was followed up to obtain vital status information. No subcohort members were lost to follow-up during the follow-up period. Follow-upFollow-up for incident cancer was established by record linkage to cancer registries and the Dutch database of pathology reports (4), and follow-up was more than 95 percent complete (5). The present analysis was restricted to 6.3 years of follow-up. After we excluded prevalent cases, 3,346 subcohort members and 619 incident cases with microscopically confirmed carcinomas of the bladder, ureters, renal pelvis, or urethra were identified. Because the overwhelming majority of tumors occurred in the bladder, and because the renal pelvis and ureter are ...

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Tobacco smoking, occupational exposure and bladder cancer in Argentina

Cited by 92 publications

References 21 publications

Risk of Bladder Cancer Associated with Family History of Cancer: Do Low-Penetrance Polymorphisms Account for the Increase in Risk?

Risk of Bladder Cancer Associated with Family History of Cancer: Do Low-Penetrance Polymorphisms Account for the Increase in Risk?

Alcohol consumption and risk of bladder cancer in Los Angeles County

Alcohol Consumption and Bladder Cancer Risk: Results from the Netherlands Cohort Study

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