Tobacco smoking and cytokine levels in human epicardial adipose tissue: Impact of smoking cessation

Mach, Lukáš; Bedáňová, Helena; Souček, Miroslav; Karpíšek, Michal; Němec, Petr; Orban, Marek

doi:10.1016/j.atherosclerosis.2016.10.022

Cited by 17 publications

(13 citation statements)

References 31 publications

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“…Of note, it is widely recognized that there is a negative interaction between adiponectin and TNF- α , investigated by in vivo study from Maeda et al [ 70 ]. In human epicardial adipose tissue, tobacco smoking induces elevated levels of TNF- α and IL-6, creating the proinflammatory profile [ 71 ]. In vitro experiments have shown that TNF- α stimulates nuclear factor-kappa B (NF- κ B), PI-3 kinase, and jun-N-terminal kinase cascades, subsequently enhancing lipolysis in periadipocytes [ 72 ].…”

Section: Link Between Cigarette Smoking and Adipose Tissue In Athementioning

confidence: 99%

Cigarette Smoking and Adipose Tissue: The Emerging Role in Progression of Atherosclerosis

Wang

2017

Mediators of Inflammation

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Smoking is an established risk factor for atherosclerosis through several underlying pathways. Moreover, in the development of atherosclerotic plaque formation, obesity, defined as excess fat mass accumulation, also plays a vital role in dyslipidemia and insulin resistance. Substantial evidence shows that cigarette smoking induces multiple pathological effects in adipose tissue, such as differentiation of adipocytes, lipolysis, and secretion properties in adipose tissue. Therefore, there is an emerging speculation in which adipose tissue abnormality induced by smoking or nicotine is likely to accelerate the progression of atherosclerosis. Herein, this review aims to investigate the possible interplay between smoking and adipose tissue dysfunction in the development of atherosclerosis.

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Section: Link Between Cigarette Smoking and Adipose Tissue In Athementioning

confidence: 99%

Cigarette Smoking and Adipose Tissue: The Emerging Role in Progression of Atherosclerosis

Wang

2017

Mediators of Inflammation

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“…In smokers we can observe changes in some cytokines and chemokines, and also T-cells and NK cells [ 11 ]. In smokers a decreased number and impaired function of NK cells was observed [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

The influence of KIR gene presence/absence polymorphisms on the development of periodontal disease in smokers and non-smokers

Mazurek−Mochol

Majorczyk

Banach

et al. 2017

cejoi

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IntroductionPeriodontal diseases are highly prevalent inflammatory, multifactorial diseases. Smoking is one of the most important environmental risk factors for the development and severity of periodontal disease. Killer cell immunoglobulin-like receptors (KIRs) are members of the immunoglobulin (Ig) superfamily and play an essential role in the regulation of NK cell activity, allowing natural killer (NK) cells to sense and respond to human leukocyte antigen (HLA) class I. The aim of this study was to evaluate the influence of KIR gene presence/absence polymorphisms on the development of periodontal disease in smokers and non-smokers.Material and methodsThis study enrolled 400 Caucasian subjects (age range 25-69 years) from the West Pomeranian region of Poland. The subjects were categorized into four subgroups (smoking and non-smoking patients with periodontal disease; smoking and non-smoking subjects without periodontal disease – control subjects).ResultsThe differences of KIR gene frequencies between non-smoking patients and non-smoking control subjects as well as smoking patients and control subjects were not statistically significant. In multivariate regression analysis advanced age of patients and smoking were independent factors associated with increased frequency of periodontal disease.ConclusionsThe results of this study suggest that the main factor associated with increased risk of periodontal disease is smoking, whereas KIR presence/absence polymorphism is not a significant factor involved in the pathogenesis of periodontal disease.

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“…The association between EFV and smoking has not been elucidated. However, epicardial adipose tissue levels of TNF- α and IL-6 were significantly elevated in current smokers when compared with never smokers and former smokers 28 ) , which supports the mechanism that epicardial adipose tissue in smokers could contribute to the pathogenesis of adverse effects of tobacco smoking.…”

Section: Discussionmentioning

confidence: 64%

Clinical Characteristics of Nonobese Patients with Acute Coronary Syndrome and Increased Epicardial Fat Volume

Harada

Suzuki

Matsunaga

et al. 2018

JAT

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Aim: Increased epicardial fat volume (EFV) is an independent risk factor for acute coronary syndrome (ACS). Although EFV increases with body mass index (BMI), some ACS patients have an increased EFV but normal BMI. We here investigated the clinical characteristics of nonobese ACS patients with an increased EFV.Methods: A total of 197 Japanese patients hospitalized for ACS was evaluated for EFV, abdominal visceral fat area (VFA), and lipid and glucose profiles. Control subjects comprised 141 individuals who were suspected of having ACS but whose coronary computed tomography findings were normal.Results: EFV was increased in ACS patients compared with control subjects (120 ± 47 versus 95 ± 45 mL, P < 0.01). ACS patients were divided into four groups based on average EFV (120 mL) and a BMI obesity cutoff of 25 kg/m2. For the 30 nonobese ACS patients with an above-average EFV, EFV was positively correlated with VFA (r = 0.23, P = 0.031). These individuals were significantly older (74 ± 10 years) and tended to have a higher homeostasis model assessment–insulin resistance value (5.5 ± 3.8) compared with other ACS patients. Among nonobese study subjects, EFV was independently associated with ACS (odds ratio= 2.01, P = 0.021) and correlated with abdominal circumference (r = 0.26, P = 0.017).Conclusion: Nonobese ACS patients with an increased EFV were elderly and tended to manifest insulin resistance. Measurement of EFV may prove informative for evaluation of ACS risk among elderly nonobese individuals with an increased abdominal girth.

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Tobacco smoking and cytokine levels in human epicardial adipose tissue: Impact of smoking cessation

Cited by 17 publications

References 31 publications

Cigarette Smoking and Adipose Tissue: The Emerging Role in Progression of Atherosclerosis

Cigarette Smoking and Adipose Tissue: The Emerging Role in Progression of Atherosclerosis

The influence of KIR gene presence/absence polymorphisms on the development of periodontal disease in smokers and non-smokers

Clinical Characteristics of Nonobese Patients with Acute Coronary Syndrome and Increased Epicardial Fat Volume

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