Tobacco smoking and breastfeeding: Effect on the lactation process, breast milk composition and infant development. A critical review

Napierała, Marek; Mazela, Jan; Merritt, T. Allen; Florek, Ewa

doi:10.1016/j.envres.2016.08.002

Cited by 155 publications

(137 citation statements)

References 119 publications

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“…However, its protection of smokers’ offspring seems to be limited. Smokers do tend to have a shorter breastfeeding period than the non‐smokers and chemicals in the tobacco smoke delivered via breastmilk can also negatively impact postnatal brain development in smokers’ offspring …”

Section: Potential Cellular Mechanismsmentioning

confidence: 99%

“…Smokers do tend to have a shorter breastfeeding period than the non-smokers 79 and chemicals in the tobacco smoke delivered via breastmilk can also negatively impact postnatal brain development in smokers' offspring. 80 It needs to be noted that in animal models the increased oxidative stress and reduced antioxidants in the brain are only present in the male offspring from SE dams. 17,18 Thus, the levels of brain markers for oxidative stress injury, mitochondrial injury and cell death are increased in the male offspring, but not their female littermates.…”

Section: Oxidative Stress In the Brainmentioning

confidence: 99%

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What lessons have we learnt about the impact of maternal cigarette smoking from animal models?

Chan

Oliver

Chen

2019

Clin Exp Pharma Physio

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Maternal first‐ or second‐hand tobacco smoking during pregnancy is still common albeit that the detrimental effects to the unborn child are well known. Maternal tobacco cigarette smoking can affect multiple organ systems in the offspring, rendering them at increased risk of various conditions throughout life (eg. intrauterine underdevelopment, asthma, substance abuse, diabetes). However, this review will only focus on its impact on the brain and the related molecular changes in the offspring based on evidence from animal studies. Although epidemiological studies have identified the associations between maternal cigarette smoke exposure (SE) and brain disorders, animal models can help identify the underlying mechanisms and test interventions. Human studies have found that maternal SE is closely linked to small brain size and changes in brain structure and associated with a high risk of cognitive defects. Animal models suggest that this may be due to increased brain oxidative stress and inflammation during the neonatal period, leading to increased brain cell apoptosis in adulthood. There is a distinct gender bias of such impacts, where male offspring are more affected than females. Female offspring seem to have developed the adaptation by increasing endogenous antioxidant levels. Indeed, animal studies have shown that using antioxidant supplementation during pregnancy can improve neurological outcomes in male offspring, however, the efficacy in humans is yet to be confirmed. Furthermore, some animal studies suggested nicotine as the key player in intrauterine underdevelopment due to maternal SE, while human clinical trials using nicotine replacement therapy do not support this mechanism. This review will discuss the possible reasons.

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Section: Potential Cellular Mechanismsmentioning

confidence: 99%

Section: Oxidative Stress In the Brainmentioning

confidence: 99%

What lessons have we learnt about the impact of maternal cigarette smoking from animal models?

Chan

Oliver

Chen

2019

Clin Exp Pharma Physio

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“…The rest forms a mixture of inorganic and organic compounds . IARC has shown that 70 of the identified compounds have carcinogenic activity, 16 of which have been included into Group 1 (substances with proven carcinogenicity to humans) . The best known are: benzo(a)pyren (B/a/P), N‐nitrosonornicotine (NNN), 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK), formaldehyde and polonium‐210 (Table ) .…”

Section: Toxicity Of Tobacco Smokementioning

confidence: 99%

“…7,26 IARC has shown that 70 of the identified compounds have carcinogenic activity, 16 of which have been included into Group 1 (substances with proven carcinogenicity to humans). [27][28][29] The best known are: benzo(a)pyren (B/a/P), N-nitrosonornicotine (NNN), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), formaldehyde and polonium-210 (Table 1). 7 To exert their carcinogenic potential a majority of these carcinogens requires metabolic activation by means of mixed function oxidases (MFO).…”

Section: Toxicity Of Tobacco Smokementioning

confidence: 99%

Molecular and health effects in the upper respiratory tract associated with tobacco smoking other than cigarettes

Szyfter

Napierała

Florek

et al. 2018

Intl Journal of Cancer

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The objective of the review was to compare molecular and health effects of tobacco smoking using cigars, cigarillos, pipe and water pipe in relation to the effects of cigarette smoking. In this review we will focus on the upper respiratory tract. Mechanisms of interaction of tobacco smoke constituents after products other than cigarettes are similar to these associated with cigarette smoking. Carcinogenic activity was demonstrated for any type of tobacco smoking, although the risk of developing head and neck squamous cell carcinoma (HNSCC) remains lower in users of cigars, traditional pipe and water pipe as compared to cigarette smoking. Nevertheless, there is no way of safe tobacco smoking.

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“…Human milk is a rich source of macro-and micronutrients, and a unique matrix of bioactive compounds that contribute to the development of intestinal microbiota, immune maturation, and organ development (Ballard and Morrow 2013;Walker and Iyengar 2015). However, its chemical composition may be prone to alterations driven by the maternal lifestyle, diet, and exposure to contaminants (Čechová et al 2016;Napierala et al 2016;Grzunov Letinić et al 2016;Torregrosa Paredes et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Rare-earth elements in human colostrum milk

Poniedziałek

Rzymski

Pięt

et al. 2017

Environ Sci Pollut Res

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Rare-earth elements (REEs) are used in a growing number of applications, and their release to environment has increased over the decades. Knowledge of REEs in human milk and factors that could possibly influence their concentration is scarce. This study evaluated the concentrations of 16 REEs (Ce, Eu, Er, Gd, La, Nd, Pr, Sc, Sm, Dy, Ho, Lu, Tb, Tm, Y, and Yb) in human colostrum milk collected from Polish women (n = 100) with the ICP-OES technique. The concentrations (mean ± SD) of Pr (41.9 ± 13.2 μg L −1 ), Nd (11.0 ± 4.0 μg L −1 ), La (7.1 ± 5.2 μg L −1 ), and Er (2.2 ± 0.8 μg L −1 ) were found above detection limits. The total mean ± SD concentration of detected REEs was 60.9 ± 17.8 μg L −1 . Current smokers displayed significantly increased Nd concentrations compared to women who had never smoked. No other associations between REEs in colostrum milk and age, diet in pregnancy (food supplement use and frequency of fish, meat, and vegetable consumption) or place of living (urban/rural) were found. This study adds to general understanding of the occurrence and turnover of REEs in women and human fluids.

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Tobacco smoking and breastfeeding: Effect on the lactation process, breast milk composition and infant development. A critical review

Cited by 155 publications

References 119 publications

What lessons have we learnt about the impact of maternal cigarette smoking from animal models?

What lessons have we learnt about the impact of maternal cigarette smoking from animal models?

Molecular and health effects in the upper respiratory tract associated with tobacco smoking other than cigarettes

Rare-earth elements in human colostrum milk

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