Tobacco smoke exposure and respiratory morbidity in young children

Snodgrass, A. M.; Tan, Kok Hian; Soh, Shu‐E; Goh, Anne; Bever, Hugo P. Van; Gluckman, Peter D.; Godfrey, Keith M.; Chong, Yap Seng; Saw, Seang‐Mei; Kwek, Kenneth; Teoh, Oon Hoe

doi:10.1136/tobaccocontrol-2015-052383

Cited by 29 publications

(20 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only 12.5% of the mothers smoked regularly prior to pregnancy and 2.3% continued to do so during their pregnancy. The authors did not examine the independent effects of smoking during pregnancy versus postnatally because of insufficient power to detect the differences [26]. An American study of 206 infants with severe bronchiolitis focused on tobacco smoke exposure and the severity of bronchiolitis (measured by low oxygen saturations), and reported that prenatal TSE was not significantly associated with lower oxygen saturation among infants hospitalized with bronchiolitis [25].…”

Section: Discussionmentioning

confidence: 99%

Prenatal and postnatal tobacco smoke exposure and risk of severe bronchiolitis during infancy

Behrooz

Balekian²,

Faridi

et al. 2018

Respiratory Medicine

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Prenatal and postnatal tobacco smoke exposure and risk of severe bronchiolitis during infancy

Behrooz

Balekian²,

Faridi

et al. 2018

Respiratory Medicine

View full text Add to dashboard Cite

show abstract

“…Literature has previously shown that offspring secondhand smoke exposure was associated with an increase in admission of respiratory diseases by 2 years of age (Snodgrass et al, 2016). We found that PTS was associated with infant frequent URIs, but the infants with frequent URIs were not significantly associated with CG methylation level of LMO2, GSTM1 , or IL10 in umbilical cord blood DNA.…”

Section: Discussionmentioning

confidence: 99%

Paternal Tobacco Smoke Correlated to Offspring Asthma and Prenatal Epigenetic Programming

Hsu

Chang

et al. 2019

Front. Genet.

View full text Add to dashboard Cite

Rationale: Little is known about effects of paternal tobacco smoke (PTS) on the offspring’s asthma and its prenatal epigenetic programming. Objective: To investigate whether PTS exposure was associated with the offspring’s asthma and correlated to epigenetic CG methylation of potential tobacco-related immune genes: LMO2, GSTM1 or/and IL-10 genes. Measurements and Main Results: In a birth cohort of 1,629 newborns, we measured exposure rates of PTS (23%) and maternal tobacco smoke (MTS, 0.2%), cord blood DNA methylation, infant respiratory tract infection, childhood DNA methylation, and childhood allergic diseases. Infants with prenatal PTS exposure had a significantly higher risk of asthma by the age of 6 than those without ( p = 0.026). The PTS exposure doses at 0, <20, and ≧20 cigarettes per day were significantly associated with the trend of childhood asthma and the increase of LMO2-E148 ( p = 0.006), and IL10_P325 ( p = 0.008) CG methylation. The combination of higher CG methylation levels of LMO2_E148, IL10_P325 , and GSTM1_P266 corresponded to the highest risk of asthma by 43.48%, compared to other combinations (16.67–23.08%) in the 3-way multi-factor dimensionality reduction (MDR) analysis. The LMO2_P794 and GSTM1_P266 CG methylation levels at age 0 were significantly correlated to those at age of 6. Conclusions: Prenatal PTS exposure increases CG methylation contents of immune genes, such as LMO2 and IL-10 , which significantly retained from newborn stage to 6 years of age and correlated to development of childhood asthma. Modulation of the LMO2 and IL-10 CG methylation and/or their gene expression may provide a regimen for early prevention of PTS-associated childhood asthma. Descriptor number: 1.10 Asthma Mediators. Scientific Knowledge on the Subject : It has been better known that maternal tobacco smoke (MTS) has an impact on the offspring’s asthma via epigenetic modification. Little is known about effects of paternal tobacco smoke (PTS) on the offspring’s asthma and its prenatal epigenetic programming. What This Study Adds to the Field : Prenatal tobacco smoke (PTS) can program epigenetic modifications in certain genes, such as LMO2 and IL-10 , and that these modifications are correlated to childhood asthma development. The higher the PTS exposure dose the higher the CG methylation levels are found. The combination of higher CG methylation levels of LMO2_E148, IL10_P325 and GSTM1...

show abstract

“…URTI in infants was defined as pediatrician-diagnosed common cold, cough, or throat infections during the first year of life. 23,27 Information about URTI was obtained by telephone interview at 3, 6, and 12 months postpartum follow-up. Mothers were asked whether and when their infant had seen a doctor since the last assessment.…”

Section: Urti Outcomementioning

confidence: 99%

Exposure to environmental tobacco smoke during pregnancy and infancy increased the risk of upper respiratory tract infections in infants: A birth cohort study in Wuhan, China

Chen

Huang

et al. 2020

Indoor Air

View full text Add to dashboard Cite

Respiratory tract infections are particularly prevalent in children younger than 5 years worldwide. 1 Considering its subtypes, upper respiratory tract infections (URTI) in young children are the most common reasons for consultation in primary care, and it is associated with a high burden of recurrent doctor visits and parental stress. [2][3][4] Epidemiological studies have shown that URTI during infancy is associated with an increased risk for developing wheeze, asthma, type 1 diabetes mellitus, and celiac diseases in later life. [5][6][7][8][9] Early occurrence of URTI could have different causes compared to those diagnosed in later childhood. 9-11 A better understanding of these risk factors is therefore essential to prevent and manage URTI in infants.

show abstract

Tobacco smoke exposure and respiratory morbidity in young children

Cited by 29 publications

References 29 publications

Prenatal and postnatal tobacco smoke exposure and risk of severe bronchiolitis during infancy

Prenatal and postnatal tobacco smoke exposure and risk of severe bronchiolitis during infancy

Paternal Tobacco Smoke Correlated to Offspring Asthma and Prenatal Epigenetic Programming

Exposure to environmental tobacco smoke during pregnancy and infancy increased the risk of upper respiratory tract infections in infants: A birth cohort study in Wuhan, China

Contact Info

Product

Resources

About