Tobacco smoke diminishes neurogenesis and promotes gliogenesis in the dentate gyrus of adolescent rats

Bruijnzeel, Adrie W.; Bauzo, Rayna M.; Munikoti, Vikram; Rodrick, Gene B.; Yamada, Hidetaka; Fornal, Casimir A.; Ormerod, Brandi K.; Jacobs, Barry L.

doi:10.1016/j.brainres.2011.07.041

Cited by 30 publications

(18 citation statements)

References 78 publications

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“…Factors possibly affecting group variability were nicotine and benzodiazepine use. In the control group, nicotine-exposed subjects had fewer NPCs in the whole DG and pes , according to the literature in lower mammals (6,71). Nicotine effect could not be tested in antidepressant-treated MDDs, which had only one smoker; untreated MDDs had double the number of non-smokers than controls, possibly blunting control-MDD differences in NPCs.…”

Section: Discussionmentioning

confidence: 62%

Hippocampal Angiogenesis and Progenitor Cell Proliferation Are Increased with Antidepressant Use in Major Depression

Boldrini

Hen

Underwood

et al. 2012

Biological Psychiatry

283

236

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Background Adult neurogenesis is coupled to angiogenesis in neurogenic niches in the dentate gyrus (DG) and increased by antidepressants in rodents. We hypothesized that, in major depressive disorder (MDD), antidepressants increase neural progenitor cells (NPCs) and capillaries in the human DG. Methods NPCs and capillaries, detected on hippocampal sections by immunohistochemistry for nestin, were quantified by stereology in matched MDDs (untreated, n=12), MDD treated with selective serotonin reuptake inhibitors (MDD*SSRI, n=6) or tricyclic antidepressants (MDD*TCA, n=6) and nonpsychiatric controls (n=12), all confirmed by psychological autopsy. Results MDD*SSRI had a larger capillary area and more NPCs versus MDDs (p=.034 and p=.008, respectively) and controls (p=.010 and p=.002, respectively) in the whole DG, more NPCs in the anterior (pes, p=.042) and central (mid-body, p=.004) DG, and greater capillary area in the pes (p=.002) and mid-body (p=.021). NPC number and capillary area correlated positively in the whole sample (R2=.454, p<.001) and in treated subjects (R2=.749, p=.001). We found no NPCs or antidepressant-related angiogenesis in CA1 and parahippocampal gyrus. DG volume correlated positively with NPC number (p=.004) and capillary area (p<.001), and differed between groups in whole hippocampus (p=.013) and mid-body (p=.036). Age negatively correlated with NPC number (p=.042), capillary area (p=.037) and bifurcations (p=.030). No sex effect was detected. Conclusions Antidepressants increase human hippocampal NPCs and angiogenesis selectively in the anterior and mid DG. These results raise the possibility of a causal relationship between angiogenesis and neurogenesis, as seen in other proliferating tissues, and support their possible role in the mechanism of action of antidepressants.

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Section: Discussionmentioning

confidence: 62%

Hippocampal Angiogenesis and Progenitor Cell Proliferation Are Increased with Antidepressant Use in Major Depression

Boldrini

Hen

Underwood

et al. 2012

Biological Psychiatry

283

236

View full text Add to dashboard Cite

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“…Embryonic neural progenitors have nicotinic cholinergic receptors (Atluri et al 2001; Schneider et al 2002) but nicotine does not show any marked antiproliferative or apoptotic effects even at concentrations up to 100 μM (Culbreth et al 2012). In contrast, nicotine does elicit apoptosis in undifferentiated stem cells (Berger et al 1998), and impairs neurogenesis in the adolescent or adult hippocampus (Bruijnzeel et al 2011; Cho and Kim 2010). Contrarily, nicotine increases proliferation in induced pluripotent stem cells (Ishizuka et al 2012)!…”

Section: Discussionmentioning

confidence: 99%

Diverse neurotoxicants target the differentiation of embryonic neural stem cells into neuronal and glial phenotypes

et al. 2016

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The large number of compounds that need to be tested for developmental neurotoxicity drives the need to establish in vitro models to evaluate specific neurotoxic endpoints. We used neural stem cells derived from rat neuroepithelium on embryonic day 14 to evaluate the impact of diverse toxicants on their ability to differentiate into glia and neurons: a glucocorticoid (dexamethasone), organophosphate insecticides (chlorpyrifos, diazinon, parathion), insecticides targeting the GABAA receptor (dieldrin, fipronil), heavy metals (Ni2+, Ag+), nicotine and tobacco smoke extract. We found three broad groupings of effects. One diverse set of compounds, dexamethasone, the organophosphate pesticides, Ni2+ and nicotine, suppressed expression of the glial phenotype while having little or no effect on the neuronal phenotype. The second pattern was restricted to the pesticides acting on GABAA receptors. These compounds promoted the glial phenotype and suppressed the neuronal phenotype. Notably, the actions of compounds eliciting either of these differentiation patterns were clearly unrelated to deficits in cell numbers: dexamethasone, dieldrin and fipronil all reduced cell numbers, whereas organophosphates and Ni2+ had no effect. The third pattern, shared by Ag+ and tobacco smoke extract, clearly delineated cytotoxicity, characterized major cell loss with suppression of differentiation into both glial and neuronal phenotypes; but here again, there was some selectivity in that glia were suppressed more than neurons. Our results, from this survey with diverse compounds, point to convergence of neurotoxicant effects on a specific “decision node” that controls the emergence of neurons and glia from neural stem cells.

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“…VLNTX downregulates activity at the mu-opioid receptor (Mannelli et al, 2004) that is selectively involved with dopamine response to hedonic stimuli (Wise, 2008), as well as to smoking and tobacco reinforcement (Domino et al, 2012;Liu & Jernigan, 2011). Clonidine moderates positive and negative smoking reinforcement through alpha-2-adrenergic agonism and GABA(B) receptor modulation (Bruijnzeel et al, 2011;Vlachou et al, 2011), though its clinical use is limited by orthostatic hypotension (Herman & Sofuoglu, 2010). A synergistic action on cigarette craving and smoking would explain the stronger efficacy of VLNTX + clonidine than each medication separately and allow use of lower doses of each drug, with reduced adverse events.…”

Section: Discussionmentioning

confidence: 99%

Smoking and Opioid Detoxification: Behavioral Changes and Response to Treatment

Mannelli

Peindl

et al. 2013

Nicotine & Tobacco Research

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Tobacco smoke diminishes neurogenesis and promotes gliogenesis in the dentate gyrus of adolescent rats

Cited by 30 publications

References 78 publications

Hippocampal Angiogenesis and Progenitor Cell Proliferation Are Increased with Antidepressant Use in Major Depression

Hippocampal Angiogenesis and Progenitor Cell Proliferation Are Increased with Antidepressant Use in Major Depression

Diverse neurotoxicants target the differentiation of embryonic neural stem cells into neuronal and glial phenotypes

Smoking and Opioid Detoxification: Behavioral Changes and Response to Treatment

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