Tobacco heating system has less impact on bone metabolism than cigarette smoke

Weng, Weidong; Bovard, David; Zanetti, Filippo; Ehnert, Sabrina; Braun, Bianca; Uynuk-Ool, Tatiana; Histing, Tina; Hoeng, Julia; Nüssler, Andreas K.; Aspera-Werz, Romina H.

doi:10.1016/j.fct.2023.113637

Cited by 5 publications

(3 citation statements)

References 71 publications

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“…Several toxic components in tobacco smoke were the same as those in particulates. Nicotine and other toxic components in tobacco smoke can promote osteoclast differentiation, which was the superimposed harmful factor of COFs ( 44 ). Similarly, total LS BMD declines in drinkers were more severe than in non-drinkers.…”

Section: Discussionmentioning

confidence: 99%

Correlation between the non-use of cooking oil fume extractors and bone mineral density in population aged 45 years and older in China: a cross-sectional study

Zhang,

Shi,

Yuan

et al. 2024

Front. Endocrinol.

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IntroductionThe correlation between the non-use of cooking oil fumes (COFs) extractors and bone mineral density (BMD) have not been clarified. Consequently, this study attempted to explore the impact of non-use COFs extractors on BMD in population aged 45 years and older based on a cross-sectional study.MethodsThis study was a cross-sectional study within the framework of an ongoing prospective population-based cohort study in China. The multivariate linear regression models were used to evaluate the correlation between the non-use of fume extractors in family cooking and total lumbar spine (LS), femoral neck (FN), total hip BMD and levels of bone metabolism markers.ResultsA total of 3433 participants were included in the final analyses, of which 2607 (75.93%) participants used fume extractors. The results of models indicated that there were significant correlations of the non-use of fume extractors on total LS BMD (β = -0.024, 95% CI, -0.036, -0.012, p < 0.001), PINP (β = 4.363, 95% CI, 2.371, 6.356, p < 0.001) and ALP (β = 4.555, 95% CI, 2.593, 6.517, p < 0.001) levels.ConclusionsThis study verified that the use of fume extractors is an efficacious measure to prevent LS bone loss. For the sake of public bone health, people should install a fume extractor in the kitchen and use it routinely when cooking.

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Section: Discussionmentioning

confidence: 99%

Correlation between the non-use of cooking oil fume extractors and bone mineral density in population aged 45 years and older in China: a cross-sectional study

Zhang,

Shi,

Yuan

et al. 2024

Front. Endocrinol.

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“…The retear rates of the propensity score-matched cigarette smoker and heated tobacco smoker groups were not significantly different, but the odds ratio (OR) for retearing was slightly lower in the heated tobacco smoker group than in the cigarette smoker group according to the multivariable logistic regression analysis. Several independent investigations have shown that heated tobacco products are less hazardous to musculoskeletal tissue than conventional cigarettes 45,46 . Aspera-Werz et al 45 showed that heated tobacco product use had significantly less harmful effects on osteoblast differentiation than conventional cigarette smoking, implying a reduced burden of oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Heated Tobacco Products Have Detrimental Effects on Rotator Cuff Healing, Similar to Conventional Cigarettes

Yoon,

Choi,

Lim

et al. 2024

Journal of Bone and Joint Surgery

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Background: Cigarette smoking impairs rotator cuff healing, but no study, to our knowledge, has focused on the association between heated tobacco products and rotator cuff tears. Methods: This study retrospectively investigated 1,133 patients who underwent arthroscopic repair of symptomatic rotator cuff tears between March 2011 and April 2021. Patients were grouped on the basis of their smoking patterns as nonsmokers, cigarette smokers, and heated tobacco smokers. Propensity score matching was used to reduce selection bias, and 45 subjects were selected from each group via 1:1:1 matching. Functional scores and active range of motion were compared among the 3 groups preoperatively and at a 2-year follow-up. Postoperative magnetic resonance imaging was performed 6 months after the surgical procedure to assess structural integrity. Results: Except for sex, similar baseline characteristics were achieved after propensity score matching. There were no differences in the clinical scores or range of motion between the matched groups either preoperatively or at the 2-year follow-up. However, the retear rate for the matched nonsmoker group was significantly lower (8.9%) than those for the matched cigarette smoker group (31.1%) and the heated tobacco smoker group (28.9%) (p = 0.022). Multivariable logistic regression analysis revealed that the retear rates were 3.403 times higher for the cigarette smoker group and 3.397 times higher for the heated tobacco smoker group than that for the nonsmoker group. Conclusions: Heated tobacco users, like conventional cigarette smokers, have worse clinical outcomes with respect to rotator cuff healing than nonsmokers. Regardless of the type of cigarette, abstinence from smoking is necessary for patients undergoing rotator cuff repair surgery. Level of Evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

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“…With respect to the articles identified that described in vitro toxicological analyses of HTPs, articles were excluded from detailed discussion in this section of the review if they did not detail a direct quantitative comparison between the HTP(s) under investigation and other nicotine-or tobacco-containing products such as cigarettes and/or EVPs (i.e., statistical analyses were reported solely between the effects of the HTP and the negative control used) [64,65]; investigated any cell line not related to tissues of the oral cavity, respiratory tract, cardiovascular system or pluripotent stem cells [66][67][68][69][70][71][72]; attempted to investigate different human exposure scenarios using the same experimental methodology (i.e., sidestream smoke released by cigarettes being compared to aerosol produced by an HTP as a means of comparing bystander exposure between products) [67].…”

Section: In Vitro Toxicologymentioning

confidence: 99%

The Product Science of Electrically Heated Tobacco Products: An Updated Narrative Review of the Scientific Literature

Cordery,

Thompson,

Stevenson

et al. 2024

Cureus

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Heated tobacco products represent a novel category of tobacco products in which a tobacco consumable is heated to a temperature that releases nicotine from the tobacco leaf but not to a temperature sufficient to cause combustion. Heated tobacco products may therefore have the potential to be a less harmful alternative for adult smokers who would otherwise continue to smoke cigarettes, as their use should result in exposure to substantially fewer and lower levels of toxicants. This update represents a two-year extension to our previous narrative review, which covered peer-reviewed journal articles published up to August 31, 2021. The scientific evidence published between 2021 and 2023 continues to indicate that aerosols produced from heated tobacco products contain fewer and substantially lower levels of harmful and potentially harmful constituents and that these observed reductions consistently translate to reduced biological effects in both in vitro and in vivo toxicological studies. Biomarker and clinical data from studies in which product use is controlled within a clinical setting continue to suggest changes in levels of biomarkers of exposure, biomarkers of potential harm, and clinical endpoints indicating the potential for reduced harm with switching to exclusive use of heated tobacco products in adult smokers. Overall, the available peer-reviewed scientific evidence continues to indicate that heated tobacco products offer promise as a potentially less harmful alternative to cigarettes, and as such, the conclusions of our original narrative review remain valid.

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Tobacco heating system has less impact on bone metabolism than cigarette smoke

Cited by 5 publications

References 71 publications

Correlation between the non-use of cooking oil fume extractors and bone mineral density in population aged 45 years and older in China: a cross-sectional study

Correlation between the non-use of cooking oil fume extractors and bone mineral density in population aged 45 years and older in China: a cross-sectional study

Heated Tobacco Products Have Detrimental Effects on Rotator Cuff Healing, Similar to Conventional Cigarettes

The Product Science of Electrically Heated Tobacco Products: An Updated Narrative Review of the Scientific Literature

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