Tobacco, alcohol use and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: The Liver Cancer Pooling Project

Petrick, Jessica L.; Campbell, Peter T.; Koshiol, Jill; Thistle, Jake E.; Andreotti, Gabriella; Freeman, Laura E. Beane; Buring, Julie E.; Chan, Andrew T.; Chong, Dawn Q.; Doody, Michele M.; Gapstur, Susan M.; Gaziano, J. Michael; Giovannucci, Edward; Graubard, Barry I.; Lee, I-Min; Liao, Linda M.; Linet, Martha S.; Palmer, Julie R.; Poynter, Jenny N.; Purdue, Mark P.; Robien, Kim; Rosenberg, Lynn; Schairer, Catherine; Sesso, Howard D.; Sinha, Rashmi; Stampfer, Meir J.; Stefanick, Marcia L.; Wactawski‐Wende, Jean; Zhang, Xuehong; Zeleniuch‐Jacquotte, Anne; Freedman, Neal D.; McGlynn, Katherine A.

doi:10.1038/s41416-018-0007-z

Cited by 161 publications

(160 citation statements)

References 50 publications

(63 reference statements)

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“…All possible cancer cases were further confirmed through review of medical and pathological records by a study physician who was blinded to exposure data, extracted information from the medical charts regarding the presence of underlying cirrhosis diagnosed by histopathology or by appropriate cross‐sectional imaging, presence of viral hepatitis (i.e., HBV/HCV infection), and the histological subtype of the cancer. Additional data on HBV/HCV infection status were also available from a nested case‐control study of HCC in the NHS/HPFS (26 cases and 78 controls), which were derived from laboratory blood tests …”

Section: Methodsmentioning

confidence: 99%

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Dietary Patterns and Risk of Hepatocellular Carcinoma Among U.S. Men and Women

Yang

Simon

et al. 2019

Hepatology

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Although adherence to healthy dietary guidelines has been associated with a reduced risk of several health outcomes, including cardiovascular diseases, type 2 diabetes, and some cancers, little is known about the role of dietary patterns in the development of hepatocellular carcinoma (HCC). We prospectively assessed the associations of three key commonly used a priori dietary patterns—the Alternative Healthy Eating Index‐2010 (AHEI‐2010), Alternate Mediterranean Diet (AMED), and Dietary Approaches to Stop Hypertension (DASH)—with risk of incident HCC in the Health Professionals Follow‐Up Study (HPFS) and the Nurses’ Health Study (NHS), two large prospective cohort studies. Diet was assessed almost every 4 years using validated food frequency questionnaires (FFQs). Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards regression. During up to 32 years of follow‐up, 160 incident HCC cases were identified. After adjustment for most HCC risk factors, participants in the highest tertile of Alternative Healthy Eating Index‐2010 (AHEI‐2010) had a multivariable HR of 0.61 (95% CI, 0.39‐0.95; Ptrend = 0.03), compared with those in the lowest tertile. There was a suggestive, but nonsignificant, inverse association for Alternate Mediterranean Diet (AMED; HR = 0.75; 95% CI, 0.49‐1.15; Ptrend = 0.18) and a null association for Dietary Approaches to Stop Hypertension (DASH; HR = 0.90; 95% CI, 0.59‐1.36; Ptrend = 0.61) in relation to the risk of HCC development. Conclusion: Our findings suggest that better adherence to the AHEI‐2010 may decrease the risk of developing HCC among U.S. adults. Future studies are needed to replicate our results, examine these associations in other populations, and elucidate the underlying mechanisms.

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Section: Methodsmentioning

confidence: 99%

“…Additional data on HBV/HCV infection status were also available from a nested case-control study of HCC in the NHS/HPFS (26 cases and 78 controls), which were derived from laboratory blood tests. (21)…”

Section: Assessment Of Primary Hccmentioning

confidence: 99%

Dietary Patterns and Risk of Hepatocellular Carcinoma Among U.S. Men and Women

Yang

Simon

et al. 2019

Hepatology

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“…All possible cancer cases were further confirmed by a study physician who was blinded to exposure data and extracted information from the medical or pathological reports regarding the presence of underlying cirrhosis diagnosed by histopathology or by appropriate cross‐sectional imaging, the presence of HBV or HCV infections and the histological subtypes of the cancer. Additional data on HBV/HCV infection status were also available from a nested case–control study of HCC in the NHS/HPFS (26 HCC cases and 78 noncases), which were derived from laboratory blood tests . Considering potential unreported cancer deaths, we further searched state vital statistics records, the National Death Index …”

Section: Methodsmentioning

confidence: 99%

“…Additional data on HBV/HCV infection status were also available from a nested case-control study of HCC in the NHS/HPFS (26 HCC cases and 78 noncases), which were derived from laboratory blood tests. 31 Considering potential unreported cancer deaths, we further searched state vital statistics records, the National Death Index. 32…”

Section: Ascertainment Of Hccmentioning

confidence: 99%

A prospective study of dairy product intake and the risk of hepatocellular carcinoma in U.S. men and women

Yang

Sui

et al. 2019

Intl Journal of Cancer

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Although increasing dairy product intake has been associated with risk of several cancers, epidemiological studies on hepatocellular carcinoma are sparse and have yielded inconsistent results. We prospectively assessed the associations of dairy products (total, milk, butter, cheese and yogurt) and their major components (calcium, vitamin D, fats and protein) with the risk of hepatocellular carcinoma development among 51,418 men and 93,427 women in the Health Professionals Follow‐Up Study and the Nurses' Health Study. Diets were collected at baseline and updated every 4 years using validated food frequency questionnaires. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards regression model. During up to 32 years of follow‐up, a total of 164 hepatocellular carcinoma cases were documented. After adjustment for most known hepatocellular carcinoma risk factors, higher total dairy product intake was associated with an increased risk of hepatocellular carcinoma (highest vs. lowest tertile, HR = 1.85, 95% CI: 1.19–2.88; ptrend = 0.009). For the same comparison, we observed significant positive associations of high‐fat dairy (HR = 1.81, 95% CI: 1.19–2.76; ptrend = 0.008) and butter (HR = 1.58, 95% CI: 1.06–2.36; ptrend = 0.04) with hepatocellular carcinoma risk. There was a nonsignificant inverse association between yogurt intake and hepatocellular carcinoma risk (HR = 0.72, 95% CI: 0.49–1.05; ptrend = 0.26). Our data suggest that higher intake of high‐fat dairy foods was associated with higher, whereas higher yogurt consumption might be associated with lower risk of developing hepatocellular carcinoma among U.S. men and women.

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“…However, there was high heterogeneity among the studies included . More recently, two different studies reported a positive association between smoking and iCCA (HR = 1.47, 95% CI 1.07‐2.02 and OR = 1.46, 95% CI 1.28‐1.66 respectively) . A meta‐analysis of eleven case‐control studies reported an increased risk also for eCCA in smokers, compared to non‐smokers (summary RR = 1.23; 95% C 1.01‐1.50) .…”

Section: Risk Factorsmentioning

confidence: 99%

Cholangiocarcinoma: Epidemiology and risk factors

Khan

Tavolari

Brandi

2019

Liver International

465

495

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Cholangiocarcinoma (CCA) is a heterogeneous disease arising from a complex interaction between host‐specific genetic background and multiple risk factors. Globally, CCA incidence rates exhibit geographical variation, with much higher incidence in parts of the Eastern world compared to the West. These differences are likely to reflect differences in geographical risk factors as well as genetic determinants. Of note, over the past few decades, the incidence rates of CCA appear to change and subtypes of CCA appear to show distinct epidemiological trends. These trends need to be interpreted with caution given the issues of diagnosis, recording and coding of subtypes of CCA. Epidemiological evidences suggest that in general population some risk factors are less frequent but associated with a higher CCA risk, while others are more common but associated with a lower risk. Moreover, while some risk factors are shared by intrahepatic and both extrahepatic forms, others seem more specific for one of the two forms. Currently some pathological conditions have been clearly associated with CCA development, and other conditions are emerging; however, while their impact in increasing CCA risk as single etiological factors has been provided in many studies, less is known when two or more risk factors co‐occur in the same patient. Moreover, despite the advancements in the knowledge of CCA aetiology, in Western countries about 50% of cases are still diagnosed without any identifiable risk factor. It is therefore conceivable that other still undefined etiologic factors are responsible for the recent increase of CCA (especially iCCA) incidence worldwide.

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Tobacco, alcohol use and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: The Liver Cancer Pooling Project

Abstract: These findings suggest that, in this relatively healthy population, smoking cessation and light-to-moderate drinking may reduce the risk of HCC.

Cited by 161 publications

References 50 publications

Dietary Patterns and Risk of Hepatocellular Carcinoma Among U.S. Men and Women

Dietary Patterns and Risk of Hepatocellular Carcinoma Among U.S. Men and Women

A prospective study of dairy product intake and the risk of hepatocellular carcinoma in U.S. men and women

Cholangiocarcinoma: Epidemiology and risk factors

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