Tobacco-alcohol amblyopia: A rare complication of prolonged alcohol abuse

Prakash, Jyoti; Ryali, Vssr; Srivastava, Kalpana; Bhat, Pallavi; Shashikumar, R; Singal, Ankit

doi:10.4103/0972-6748.98424

Cited by 11 publications

(6 citation statements)

References 6 publications

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“…Tobacco use has been associated with changes in mitochondrial morphology, resulting in a decrease in ciliary activity and resultant cell death [ 6 ]. Additionally, both tobacco and alcohol impair vascular circulation systemically, including decreasing blood flow to the optic nerve with chronic overuse [ 7 ]. As in our patient, the visual acuity can often drop to as low as 20/400 in combined tobacco-alcohol toxic optic neuropathy.…”

Section: Discussionmentioning

confidence: 99%

Choroidal Neovascularization and Toxic Optic Neuropathy Secondary to Tobacco Use: A Case Report

Islam

Khurshid

2020

Cureus

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Tobacco and alcohol dependence are known to cause choroidal neovascularization and toxic optic neuropathy, although these typically occur in isolation. In this case report, we describe a 54-year-old male who presented with a juxtafoveal choroidal neovascular membrane (CNVM) in the left eye. Over the course of the next two years, his vision worsened significantly in both eyes, and he developed decreased color vision and paracentral scotomas. Impaired photoreceptor response was detected on full-field electroretinography in both eyes. MRI of the brain and orbits was normal, and laboratory tests for optic neuropathy were within normal limits, except for highly elevated cotinine and nicotine levels. He was in the habit of chewing tobacco nearly constantly, and he admitted to drinking 15-20 alcoholic beverages per week. He was diagnosed with choroidal neovascularization and optic atrophy due to tobacco and alcohol overuse. The effects of tobacco and alcohol use on the health of the choroidal vasculature and optic nerve are discussed in the article.

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Section: Discussionmentioning

confidence: 99%

Choroidal Neovascularization and Toxic Optic Neuropathy Secondary to Tobacco Use: A Case Report

Islam

Khurshid

2020

Cureus

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“…Hayreh et al 37 did not show any association with smoking. Smoking with/without alcohol leads to dysfunction of electron transport chain of mitochondria leading to cell death with damage to papillomacular bundle because of combined toxic cyanide and formic acid levels along with nutritional deficiency of vitamin B12, folate, thiamine, etc 3839. It is initially manifested as a change in colour vision and later on causes progressive decline in visual acuity leading to a central fixation scotoma.…”

Section: Nicotinementioning

confidence: 99%

Illicit drugs: Effects on eye

2019

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There is a myriad of changes that can be produced in the eye by toxic drugs ranging from mild/no symptoms to severe loss of vision from endophthalmitis. The routes of administration include oral ingestion, smoking, nasal inhalation, intravenous injection, topical application or application to other mucosal surfaces. It is important to recognize certain clinical signs and symptoms in the eye produced by these toxins. This article describes in brief some of the ocular effects of commonly abused drugs. For identification of a particular poisoning, in addition to the clinical presentation, pulse, blood pressure, respiration and body temperature, pupillary size, pupillary reaction to light, ocular convergence and nystagmus can be useful indicators of the type of drug the patient is exposed to. Unmasking these features help the clinician in an early and accurate diagnosis of the offending drug as well as timely management.

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“…Toxic Optic Neuropathies represent a type of disorder in which progressive, bilateral, and unpainful decrease of visual acuity appears [2,4,5,8]. Among the most important modifications is the affectation of the chromatic sense, described by most authors, which appears early and consists in the fact that patients notice that certain colors, particularly red, are less bright [2,8]; additionally, the visual field exam emphasizes the presence of a scotoma, initially nasal located, which increases in dimensions, surrounding the fixation point and the preservation of the peripheral visual field.…”

Section: Introductionmentioning

confidence: 99%

Tobacco-Alcohol Toxic Optic Neuropathy

Constantin¹,

Ion²,

Constantin

2019

rjo

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Purpose. To present the case of a 34-year-old man with sudden bilateral decrease of visual acuity, followed by a complete and fast recovery. Material and methods. We reported a case of an apparently healthy 34-year-old patient with sudden and unpainful decrease of visual acuity, presumed of toxic etiology. The patient was treated at the debut of the symptomatology, thus having a favorable evolution during hospitalization, with the full recovery of his visual acuity, without complications. Conclusions. Tobacco-Alcohol Toxic Optic Neuropathy has an unknown pathophysiological mechanism that allows very good recovery of visual acuity, if treated early.

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Tobacco-alcohol amblyopia: A rare complication of prolonged alcohol abuse

Cited by 11 publications

References 6 publications

Choroidal Neovascularization and Toxic Optic Neuropathy Secondary to Tobacco Use: A Case Report

Choroidal Neovascularization and Toxic Optic Neuropathy Secondary to Tobacco Use: A Case Report

Illicit drugs: Effects on eye

Tobacco-Alcohol Toxic Optic Neuropathy

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