To the mechanisms of the protective effects of regional anesthesia in relation to the development of postoperative cognitive dysfunction

Strashnov, Viktor I.; Иванович, Страшнов Виктор; Galstyan, David S.; Николаевич, Забродин Олег

doi:10.17816/rcf16262-68

Cited by 3 publications

(1 citation statement)

References 10 publications

(20 reference statements)

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“…RA has been found to be more effective in providing pain management in upper limb surgery than in GA.[ 5 ] Furthermore, it has been observed to reduce the incidence of postoperative cognitive dysfunction and mitigate the probability of adverse effects such as deep vein thrombosis, pneumonia, and pulmonary embolism. [ 6 7 ] PN blocks are frequently utilized in surgical procedures involving the upper extremities, particularly in patients suffering from perioperative pain in the upper extremity. [ 8 ] To perform RA of the upper extremity, the anesthesiologist must be well-versed in the anatomy of the brachial plexus (BP) to optimize block selection and placement.…”

Section: Upper Limbmentioning

confidence: 99%

Regional anesthesia for geriatric population

Al Harbi,

Alshaghroud,

Aljahdali

et al. 2023

Saudi J Anaesth

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Advancements in modern health care over 20 years have substantially increased the average lifespan in developed countries, and the fastest growing population is the elderly population. The proportion of people in Saudi Arabia aged 60 or more is predicted to be 25 percent of the total population of 40 million by the end of 2050. Moreover, the number of people aged 80 or more is expected to reach 1.6 million or 4 percent of the total population in the same period. Improvements in surgical techniques, anesthesia, and intensive care units make surgical interventions in older and sicker patients possible. It is estimated that over half of the population older than 65 years will require surgical intervention at least once during the remainder of their lives. Therefore, elderly patients are becoming an even larger part of anesthetic practice. Regional anesthesia (RA) is frequently used in elderly patients, especially during orthopedic surgery, genitourologic and gynecologic procedures, and hernia repair. Although age can no longer be considered a contraindication to anesthesia and surgery, anesthesia-related morbidity and mortality remain higher among elderly than among young adult surgical patients. Undoubtedly, peripheral nerve (PN) blocks improve analgesia and reduce opioid consumption and their associated side effects. This is beneficial in the perioperative care of elderly patients who may have less physiologic reserve to withstand the side effects of general anesthesia (GA).

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Section: Upper Limbmentioning

confidence: 99%

Regional anesthesia for geriatric population

Al Harbi,

Alshaghroud,

Aljahdali

et al. 2023

Saudi J Anaesth

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Etiology and Pathogenesis of Postoperative Cognitive Dysfunction (Review)

Неймарк

Shmelev

Rakhmonov

et al. 2023

Obŝaâ reanimatologiâ

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Impairment of higher mental functions can complicate the course of the postoperative period even after short and minimally invasive, including laparoscopic, surgical procedures. Postoperative cognitive dysfunction signiﬁcantly challenges patients’ quality of life, negating real success of surgical intervention and anesthetic support. In some cases, early postoperative cognitive dysfunction may be one of the main predictors of persistent cognitive impairment.The purpose of the review. To contemplate etiology, pathogenesis and the current perspective of postoperative cognitive dysfunction.We analyzed 96 publications in various databases (PubMed, Medline, RSCI and others), including 67 papers published over the past 5 years.The review provides an overview of current deﬁnitions and classiﬁcation of postoperative cognitive dysfunction, data on the prevalence, polyethyology and risk factors, potential impact of the type of anesthesia and surgical intervention on the development of postoperative cognitive dysfunction. Various pathogenetic mechanisms of higher mental functions impairment alongside with available eﬀective pharmacotherapies to correct them were considered.Conclusion. Numerous adverse factors of the perioperative period, such as neurotoxic eﬀects of general anesthetics, neuroinﬂammation in response to operational stress and surgical trauma, impaired autoregulation of the cerebral blood ﬂow, imperfect oxygen homeostasis, interactions of neurotransmitter, etc., can potentially cause postoperative cognitive dysfunction. Further deeper insights into etiology and pathogenesis of early postoperative cognitive dysfunction are relevant and necessary to improve prevention strategies and identify most eﬀective pharmacotherapies to correct such disorders.

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A change in cognitive abilities after general anesthesia

Morozov,

Sorokovikova,

Alutin

et al. 2023

Vrach

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The paper analyzes the current Russian and foreign literature on postoperative cognitive dysfunction (PCD). According to the statistics, after surgery under general anesthesia, some degree of cognitive dysfunction occurs in approximately 50% of the patients. At this moment, there are effective methods for PCD prevention and treatment. At the same time it is necessary to note that the type of a surgical intervention should be primarily taken into account in clinical practice, because in some cases the selection of the optimal type of anesthesia plays a more important role in the prevention of PCD, as compared to other options.

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To the mechanisms of the protective effects of regional anesthesia in relation to the development of postoperative cognitive dysfunction

Cited by 3 publications

References 10 publications

Regional anesthesia for geriatric population

Regional anesthesia for geriatric population

Etiology and Pathogenesis of Postoperative Cognitive Dysfunction (Review)

A change in cognitive abilities after general anesthesia

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