Data on factors contributing to the development of postoperative cardiac complications (myocardial infarction, heart failure, cardiac arrhythmias) in non-cardiosurgical operations are presented. Hypotension and blood loss are usually distinguished among such factors, but less attention is paid to the role of neuroendocrine reactions, in particular, hyperactivation of the sympathoadrenal system; the protective effect of anesthesia, in particular, regional anesthesia: epidural anesthesia and spinal anesthesia. Therefore, the review focuses on the description of the protective effects of regional anesthesia and their mechanisms, in particular, the prevention of the development of postoperative neurogenic dystrophy of internal organs, including the cardiovascular system.