Background: Anxiety and depressive disorders affect Multiple Sclerosis (MS) patients since the early stages of the disease. Although the presence of these symptoms is widely recognized, the beginning and the psychological mechanisms at the basis of these disorders have rarely been examined in detail. This observational study aims to assess the presence of emotional distress in the early stages of the disease in patients with relapsing-remitting MS (MS-RR) and to check similarities and dissimilarities with a shared conceptual framework: the "curve of change" of the Kübler-Ross model. Thirtysix RR-MS patients were examined at 1 and 24 months after the diagnosis, and they were asked to answer to the questionnaire "State-Trait Anxiety Inventory (STAI X-1 and X-2) for the evaluation of anxiety, Beck Depression Inventory 2 nd Edition (BDI-II)", for the assessment of depressive symptoms. Results: STAI X-1 scores were signifi cantly higher than the BDI II during the fi rst 6 months, while the mean BDI II resulted higher from the 18 th to the 22 th month, especially on the cognitive domain. Conclusions: The study showed that psychological symptoms follow a clearly time course in newly diagnosed patients. During the fi rst six months we found high levels of anxiety with a decrease until the fi rst year of MS disclosure. From the fi rst year on depressive symptoms begin to increase with a signifi cant involvement of the cognitive domain. During the 20 th month the depressive symptomatology reaches its highest level. The time course of the anxiety and depression symptoms in RR-MS patients is in accordance with the Kübler-Ross model.