To Synthesize Hydroxyapatite by Modified Low Temperature Method Loaded with Bletilla striata Polysaccharide as Antioxidant for the Prevention of Sarcopenia by Intramuscular Administration

Liang, Ya‐Jyun; Hong, Jia-Yu; Yang, I‐Hsuan; Zhou, Xin‐Ran; Lin, Yi‐Wen; Lin, Tzu‐Chieh; Hou, Chun‐Han; Lin, Feng‐Huei

doi:10.3390/antiox10030488

Cited by 16 publications

(7 citation statements)

References 38 publications

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“…It has high ornamental value ( Xi et al, 2020 ), and its tubers are used in traditional Chinese medicine to treat gastric ulcers, inflammation, silicosis tuberculosis and pneumogastric hemorrhage ( Zhang et al, 2021 ; Zhou et al, 2021 ). Several studies have confirmed that the anti-inflammatory, antioxidant, antibacterial, and anti-tumor effects exhibited by B. striata ( Li et al, 2018 ; Xu et al, 2019 ; Liang et al, 2021 ) occur as a result of its secondary metabolites, especially extractum, polysaccharides phenolic compound, and militarine present in the tubers ( Jiang et al, 2013 ). Therefore, it is of great significance to improve the accumulation of secondary metabolites in plants.…”

Section: Introductionmentioning

confidence: 99%

Soil Microbial Communities Affect the Growth and Secondary Metabolite Accumulation in Bletilla striata (Thunb.) Rchb. f.

Xiao

Jiang

et al. 2022

Front. Microbiol.

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Bletilla striata (Thunb.) Rchb.f. is a perennial herb belonging to the Orchidaceae family. Its tubers are used in traditional Chinese medicine to treat gastric ulcers, inflammation, silicosis tuberculosis, and pneumogastric hemorrhage. It has been reported that different soil types can affect the growth of B. striata and the accumulation of secondary metabolites in its tubers, but the biological mechanisms underlying these effects remain unclear. In this study, we compared agronomic traits and the accumulation of secondary metabolites (extractum, polysaccharide, total phenol, militarine) in B. striata grown in sandy loam or sandy clay soil. In addition, we compared physicochemical properties and microbial communities between the two soil types. In pot experiments, we tested how irradiating soil or transplanting microbiota from clay or loam into soil affected B. striata growth and accumulation of secondary metabolites. The results showed that sandy loam and sandy clay soils differed significantly in their physicochemical properties as well as in the structure and composition of their microbial communities. Sandy loam soil had higher pH, SOM, SOC, T-Ca, T-N, T-Mg, T-Mn, T-Zn, A-Ca, A-Mn, and A-Cu than sandy clay soil, but significantly lower T-P, T-K, T-Fe, and A-P content. Sandy loam soil showed 7.32% less bacterial diversity based on the Shannon index, 19.59% less based on the Ace index, and 24.55% less based on the Chao index. The first two components of the PCoA explained 74.43% of the variation in the bacterial community (PC1 = 64.92%, PC2 = 9.51%). Similarly, the first two components of the PCoA explained 58.48% of the variation in the fungal community (PC1 = 43.67%, PC2 = 14.81%). The microbiome associated with sandy clay soil can promote the accumulation of militarine in B. striata tubers, but it inhibits the growth of B. striata. The accumulation of secondary metabolites such as militarine in B. striata was significantly higher in sandy clay than in sandy loam soil. Conversely, B. striata grew better in sandy loam soil. The microbiome associated with sandy loam soil can promote the growth of B. striata, but it reduces the accumulation of militarine in B. striata tubers. Pot experiment results further confirmed that the accumulation of secondary metabolites such as militarine was higher in soil transplanted with loam microbiota than in soil transplanted with clay microbiota. These results may help guide efforts to improve B. striata yield and its accumulation of specific secondary metabolites.

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Section: Introductionmentioning

confidence: 99%

Soil Microbial Communities Affect the Growth and Secondary Metabolite Accumulation in Bletilla striata (Thunb.) Rchb. f.

Xiao

Jiang

et al. 2022

Front. Microbiol.

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“…They were tested on the treadmill and their grip strength, and the antioxidant supplement employed in this study was Bletilla striata (BSP). Finally, the authors observed that BSP improved grip strength, muscular mass, and muscular endurance in these rats (Table 1) [100].…”

Section: Sarcopenia Antioxidant Supplementation and Exercisementioning

confidence: 87%

“…Regular exercise is an essential strategy to avoid sarcopenia, but many older individuals are unwilling to exercise due to sarcopenia's complicated nature, with its disease-related and age-related signs [99]. Liang et al (2021) studied male Sprague-Dawley rats. Lipopolysaccharide (LPS) muscle injury was used to produce ROS and sarcopenia.…”

Section: Sarcopenia Antioxidant Supplementation and Exercisementioning

confidence: 99%

An Overview of Physical Exercise and Antioxidant Supplementation Influences on Skeletal Muscle Oxidative Stress

2021

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One of the essential injuries caused by moderate to high-intensity and short-duration physical activities is the overproduction of reactive oxygen species (ROS), damaging various body tissues such as skeletal muscle (SM). However, ROS is easily controlled by antioxidant defense systems during low to moderate intensity and long-term exercises. In stressful situations, antioxidant supplements are recommended to prevent ROS damage. We examined the response of SM to ROS generation during exercise using an antioxidant supplement treatment strategy in this study. The findings of this review research are paradoxical due to variances in antioxidant supplements dose and duration, intensity, length, frequency, types of exercise activities, and, in general, the lack of a regular exercise and nutrition strategy. As such, further research in this area is still being felt.

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“…Additionally, BSP fraction exhibited signi cant gastroprotective effects against ethanol-induced gastric mucosal lesion in rats by decreasing pro-in ammatory cytokines production, relieving oxidative stress and inhibiting MAPK/NF-κB pathways (Zhang et al 2019). The antioxidant effect was also con rmed that BSP could suppress lipopolysaccharide-induced ROS generation in C2C12 myoblasts (Liang et al 2021). Interestingly, some evidences showed that BSP had good anti-in ammatory and antioxidant effects to enhance endothelial cell proliferation and wound healing, suggesting its potential role in the recovery of tissue repair (Chen et al 2020a;Chen et al 2020b;Lai et al 2018).…”

Section: Introductionmentioning

confidence: 85%

Bletilla striata polysaccharides protect against mercury-induced oxidative damage to Drosophila midguts via modulation of sestrin

Chen

Wen

2022

Preprint

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Oxidative stress was one of the major causes of heavy metal-induced toxicity in organisms including Drosophila melanogaster. Bletilla striata polysaccharide (BSP) with anti-oxidative property has been recently recognized as a novel player in the management of oxidative stress response in organisms. Here, we took Drosophila midgut as a model to evaluate the protective effects of BSP (50 µg/mL) on mercury chloride-induced gastrointestinal adversities. As a result, BSP was found to significantly improve the survival rates and climbing ability of flies exposed to mercury. Further study demonstrated that BSP significantly alleviated the mercury-induced injury to midgut epithelium, at least partly, through increasing antioxidant enzyme activity (glutathione-S-transferase and superoxide dismutase), decreasing reactive oxidative species production, inhibiting cell apoptosis, restoring intestinal epithelial barrier and regulating stem cell-mediated tissue regeneration. Additionally, oxidative stress responsive gene sestrin was involved in the protection of BSP against mercury-induced oxidative damage to midguts. This study suggested that BSP has great potential for future application in the treatment and prevention of heavy metal-induced gastrointestinal adversities in mammals.

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To Synthesize Hydroxyapatite by Modified Low Temperature Method Loaded with Bletilla striata Polysaccharide as Antioxidant for the Prevention of Sarcopenia by Intramuscular Administration

Cited by 16 publications

References 38 publications

Soil Microbial Communities Affect the Growth and Secondary Metabolite Accumulation in Bletilla striata (Thunb.) Rchb. f.

Soil Microbial Communities Affect the Growth and Secondary Metabolite Accumulation in Bletilla striata (Thunb.) Rchb. f.

An Overview of Physical Exercise and Antioxidant Supplementation Influences on Skeletal Muscle Oxidative Stress

Bletilla striata polysaccharides protect against mercury-induced oxidative damage to Drosophila midguts via modulation of sestrin

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