To study the prescription pattern of antibiotics in medicine intensive care unit at tertiary care hospital

Abstract

Background: Drug utilization studies are crucial and create a positive awareness about proper use of drugs. Analysing the pattern of prescriptions is important in the settings of intensive care units where patients receive multiple antibiotics. The objective of this study was to analyse the use of antibiotics in a Medicine Intensive Care Unit (MICU) of Government Medical College and Hospital, Aurangabad, Maharashtra, India, a tertiary health care centre.Methods: Total 988 number of patients admitted in MICU from January 2017 to June 2018 were enrolled in the study and fulfilling inclusion criteria. Demographic details, disease state and prescription of antibiotic was recorded.Results: Out of 988, n=700 patients received antibiotics. Most common diseases for which patients were admitted in MICU included OP poisoning (24.86%), snake bite (15.14%), bilateral pneumonitis (12.71%), HELLP syndrome (12.14%), and the least common conditions were chronic obstructive pulmonary disease (COPD), meningitis, sepsis with multiple organ dysfunction syndrome (MODS), Guillen barre syndrome (GBS), lung abscess etc., Most common single antibiotic used in the studied cases was ceftriaxone (21.42%) followed by either alone or in combination piperacillin and tazobactam (12.04%), metronidazole (11.85%) etc.Conclusions: Total 700 patients received systemic antibiotics in present study bringing the incidence of systemic antibiotics use in MICU to be 70.85%. Ceftriaxone and combination of piperacillin and tazobactam are most commonly used antibiotics in MICU of the hospital. All patients admitted in this MICU received antibiotics as per the standard protocols of the hospital.

New Antibiotic Prescription Pattern in Critically Ill Patients (“Ant-critic”): Prospective Observational Study from an Indian Intensive Care Unit

“… 10 – 14 In only other published study that looked into antibiotic prescription pattern in an Indian ICU, 70.85% of patients were reported to receive antibiotics during ICU stay. 19 However, the rate of empirical prescription (93.12%) in this study is substantially higher compared to 45–71% reported in earlier studies. 12 – 14 This high rate of empirical prescription could possibly reflect high burden of infections (both perceived and real), widely prevailed culture of fear-based prescription of antibiotic and lack of regulation on antibiotic prescription.…”

Study of Prescribing Pattern of Antimicrobial Agents in Medicine Intensive Care Unit of a Tertiary Care Hospital

“…Moreover, generic drugs are more cost-effective than the branded one [31]. In our study, male to female ratio was 1.25, whereas in studies conducted by John et al [13] and Naikwadi et al [14], it was 1.9 and 1.4, respectively. Similar male preponderance has been shown in previous studies [15,16].…”

“…found mean age to be 34.16±14.13 [14] while Mangrulkar et al showed In MICU, patients are always in critical condition, so they frequently receive drugs by the parental route to combat the emerging lifethreatening situation. The most common dosage form used for AMA was injection (76.08%), which is similar to a study by Pandiamunian and Somasundaram (72.56%) [20].…”