To study the mechanism of Cuscuta chinensis Lam. And Lycium barbarum L. in the treatment of asthenospermia based on network pharmacology

Wang, Jisheng; Bao, Binghao; Meng, Fanchao; Deng, Sheng; Dai, Hengheng; Feng, Junlong; Li, Haisong; Wang, Bin

doi:10.1016/j.jep.2021.113790

Cited by 19 publications

(19 citation statements)

References 24 publications

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“…In recent years, GTW has been widely used for the establishment of rat models of spermatogenic dysfunction (Zhao et al., 2016). Our previous study found that GTW administered via the stomach(40 mg kg −1 d −1 ) for 4 weeks can be used to establish a rat model of spermatogenic dysfunction (Wang et al., 2021b).…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, GTW has been widely used for the establishment of rat models of spermatogenic dysfunction (Zhao et al, 2016). Our previous study found that GTW administered via the stomach(40 mg kg −1 d −1 ) for 4 weeks can be used to establish a rat model of spermatogenic dysfunction (Wang et al, 2021b). Additionally, it is known that sperm motility mainly depends on the movement of the sperm flagellum, and the energy for this is mainly provided by mitochondrial oxidative phosphorylation or glycolysis (Guthrie & Welch, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Glucosides of Tripterygium wilfordii Hook F (GTW) are commonly used in the treatment of rheumatoid arthritis, but long‐term use of GTW impairs reproductive function. In this study, GTW was used to establish cell and rat models of spermatogenic dysfunction (Wang et al., 2021a). After establishing the models, LEV and the PI3K pathway inhibitor LY294002 were administered.…”

Section: Introductionmentioning

confidence: 99%

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The mechanism analysis using PI3K/AKT pathway for the effects of levocarnitine in the treatment of spermatogenic dysfunction

et al. 2021

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According to the World Health Organization, infertility is defined as the inability to conceive after 1 year of unprotected intercourse (Zegers-Hochschild et al., 2009). Worldwide, about 10%-15% of couples have infertility (Lotti & Maggi, 2018). The study of Agarwal et al.showed that male infertility rates were highest in Africa and Central/ Eastern Europe, whereas corresponding rates for North America, Australia, and Central and Eastern Europe varied from 4.5%-6%, 9% and 8%-12% respectively (Agarwal et al., 2015). While the most powerful negative predictive factor of fertility is increasing women's age at conception (Hart, 2016), other factors including lifestyle and environmental factors are believed to play an increasing role.Treatment measures include symptomatic treatments such as oestrogen receptor modulators, sperm nutrition agents and antibiotics, whose clinical efficacy remains to be proven (Cannarella et al., 2019;

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The mechanism analysis using PI3K/AKT pathway for the effects of levocarnitine in the treatment of spermatogenic dysfunction

et al. 2021

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“…The medication was thoroughly dissolved in deionized water to make suspension (0.6 g per ml) after being grounded into a powder form. The suspension was then kept at 4°C temperature and thoroughly shaken before use (Li et al, 2020; Wang, Bao, Meng, Deng, Dai, et al, 2021).…”

Section: Methodsmentioning

confidence: 99%

“…The NC group rats were given a daily dose of 10 ml of Zuoguiwan granules solution per kg of total body weight. The duration of intragastric administration was 7 days (Li et al, 2020; Wang, Bao, Meng, Deng, Dai, et al, 2021).…”

Section: Methodsmentioning

confidence: 99%

Zuogui Wan improves spermatogenesis of GC1‐spg cells through modulating AR‐related pathways

et al. 2022

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Zuogui Wan (ZGW) is a common prescription medication used in traditional Chinese medicine (TCM) to significantly improve the sperm quality and treat male infertility. This study evaluated the repair effect of ZGW and Levocarnitine (LEV) on GC1‐spg cell injury induced by Glucosides of Tripterygium WilforDII Hook (GTW). The results showed that the ultrastructure and apoptosis rate of GC1‐ spg cells in LEV and ZGW group were considerably better than GTW. The transcriptional and translational level of CYP1A1, CYP17A1, androgen receptor (AR), SRD5A2 and proliferating cell nuclear antigen (PCNA) in GC‐1spg cells of the LEV group were considerably elevated than GTW group (p < 0.05 or 0.01). Furthermore, the transcriptional and translational levels of CYP19A1, CYP17A1, AR, SRD5A2 and PCNA in GC‐1spg cells in ZGW group were found to be considerably elevated than the LEV group (p < 0.05 or 0.01). The findings indicate that ZGW and LEV could increase the expression of PCNA, CYP17A1, CYP19A1, SRD5A2 and AR at transcriptional and translational levels, inhibit GC‐1spg cell apoptosis and promoting cell proliferation, and the effect of ZGW was found to be significantly better than that of LEV.

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Wu-Zi-Yan-Zong-Wan protects mouse blood-testis barrier from Tripterygium wilfordii Hook. f. multiglycoside-induced disruption by regulating proinflammatory cytokines

Pan

Gao

Liu

et al. 2021

Journal of Ethnopharmacology

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To study the mechanism of Cuscuta chinensis Lam. And Lycium barbarum L. in the treatment of asthenospermia based on network pharmacology

Cited by 19 publications

References 24 publications

The mechanism analysis using PI3K/AKT pathway for the effects of levocarnitine in the treatment of spermatogenic dysfunction

The mechanism analysis using PI3K/AKT pathway for the effects of levocarnitine in the treatment of spermatogenic dysfunction

Zuogui Wan improves spermatogenesis of GC1‐spg cells through modulating AR‐related pathways

Wu-Zi-Yan-Zong-Wan protects mouse blood-testis barrier from Tripterygium wilfordii Hook. f. multiglycoside-induced disruption by regulating proinflammatory cytokines

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