To study the efficacy and tolerability of fenugreek seed powder as add-on therapy with metformin in patients of type-2 diabetes mellitus

Kaur, Manmeet; Singh, Namita; Sharma, Geeta; Singh, Davinder

doi:10.18203/2319-2003.ijbcp20160748

Cited by 11 publications

(15 citation statements)

References 11 publications

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“…Glycemia control was associated with a reduction in risk of infection [25]; the results of the study, conducted by Kaur and et al (2016) [26], are pertinent to that study. In the study by Kaur et al, fenugreek seed powder was used as an add-on therapy along with metformin and evaluated in 60 Type 2 diabetes mellitus (DM) patients for 12-week duration.…”

Section: Discussionmentioning

confidence: 94%

“…In the study by Kaur et al, fenugreek seed powder was used as an add-on therapy along with metformin and evaluated in 60 Type 2 diabetes mellitus (DM) patients for 12-week duration. At the end of 12 weeks, the intervention group (in which 1 g of fenugreek seed powder was used as an add-on therapy to the metformin) showed a statistically significant decrease in fasting, postprandial blood sugar levels and HbA1c levels, as compared to those in the control group who received only metformin (p< 0.05) [26].…”

Section: Discussionmentioning

confidence: 96%

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Prebiotic prophylaxis of ventilator-associated pneumonia: A randomized clinical trial

et al. 2018

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Introduction: There is evidence of the curing effects of prebiotics in promoting growth of bifid bacterium in the digestive system and the central role of bacteria colonization in the pathogenesis of ventilator-associated pneumonia (VAP). The purpose of this study was to evaluate the effects of administration of a prebiotic, namely fenugreek seeds, on VAP prevention and clinical outcomes in critically ill patients. Methods: In this study, 60 mechanically ventilated patients were randomly divided into 2 groups (n=30 per group). Group 1 was given fenugreek seed powder by gavage, twice a day in addition to routine care, while group 2 received only routine care. Demographic and clinical data were recorded and clinical responses to the primary component (prevalence of VAP) and secondary component (other clinical factors) were interpreted. Data were analyzed via SPSS v.20, using student t-test, chi-square test, repeated measure ANOVA, and Wilcoxon test. Result: There was a significant reduction of patients diagnosed with VAP, as well as clostridium difficileassociated diarrhea and some complications of mechanical ventilation, in group 1 when compared to group 2. In addition, improvement in VAP was significantly greater for group 1 as compared with group 2. Mortality rates were not different between the two groups. Conclusion: The present study demonstrated that daily diet with fenugreek seeds can be used as an add-on therapy with other medications in prevention of VAP. As a result, the use of fenugreek seeds in the treatment plan of patients undergoing long-term intubation is recommended.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 96%

Prebiotic prophylaxis of ventilator-associated pneumonia: A randomized clinical trial

et al. 2018

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“…These findings were based on the findings of other scientists on the use of fenugreek for treating gastrointestinal disorders and in cooking [19]. Furthermore, the relationship between elevated blood glucose and deleted gastric emptying led to a study, conducted by Kaur and et al (2016), confirming the results of the previous article [20]. This study on 60 Type 2 diabetes mellitus patients demonstrated that simultaneous use of fenugreek seeds and metformin tablets for 12-week duration improved fasting blood glucose (FBS) and GI side effects of metformin (such as heartburn, nausea, abdominal pain, bloating and diarrhea), as compared to those in the control group who received only metformin (p< 0.05) [20].…”

Section: Discussionmentioning

confidence: 95%

“…Furthermore, the relationship between elevated blood glucose and deleted gastric emptying led to a study, conducted by Kaur and et al (2016), confirming the results of the previous article [20]. This study on 60 Type 2 diabetes mellitus patients demonstrated that simultaneous use of fenugreek seeds and metformin tablets for 12-week duration improved fasting blood glucose (FBS) and GI side effects of metformin (such as heartburn, nausea, abdominal pain, bloating and diarrhea), as compared to those in the control group who received only metformin (p< 0.05) [20]. Fenugreek seeds induced selective stimulation of useful intestinal microflora, improved and adjusted the microbial microflora ratio of the intestine, increased mucosal secretion, and decreased GI complications of metformin tablets.…”

Section: Discussionmentioning

confidence: 99%

Effects of fenugreek seed powder on enteral nutrition tolerance and clinical outcomes in critically ill patients: A randomized clinical trial

et al. 2018

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Background: Enteral nutrition (EN) intolerance is a common complication in critically ill patients that contributes to morbidity and mortality. Based on the evidence of curing effects of fenugreek seeds in some gastrointestinal disorders, this study aimed to determine the effects of fenugreek seed powder on enteral nutrition tolerance and clinical outcomes in critically ill patients. Materials & Methods: A randomized, double-blinded clinical trial of 5-day duration was conducted on 60 mechanically ventilated patients divided in 2 groups (n=30). Group 1 was given fenugreek seed powder by gavage, twice a day in addition to routine care, while Group 2 received only routine care. Enteral nutrition tolerance and clinical outcomes were measured throughout the study. Demographic and clinical data were recorded and clinical responses to the primary outcome (enteral nutrition tolerance) and secondary outcome (other clinical factors) were interpreted. Data were analyzed using the independent t-test, Chi-squared test, covariance analysis, and repeated measure ANOVA via SPSS statistical software (v. 20); statistical significance was set at p< 0.05. Results: Patients who were fed with the fenugreek seed powder showed a significant improvement in enteral nutrition tolerance, as well as some complications of mechanical ventilation for Group 1, as compared with Group 2. The mortality rates were not different between the two groups. Conclusion: This study shows the beneficial effects of fenugreek seeds on food intolerance in critically ill patients and that the seed powder can be used as an add-on therapy with other medications. Thus, the use of fenugreek seeds to treat mechanically ventilated patients is recommended.

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“…Furthermore, GIMM produces short-chain fatty acids instead of lactic acid in the body which reduces gastrointestinal complications of drugs 17 . Indeed, fenugreek (herbal agent) has been and is a common herbal medicine in the field of diabetes 18 .…”

Section: Introductionmentioning

confidence: 99%

Effects of fenugreek seed powder on stress-induced hyperglycemia and clinical outcomes in critically ill patients: A randomized clinical trial

et al. 2018

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Introduction: Stress-induced hyperglycemia (SIH) is commonly observed in critically ill patients and associated with poor clinical outcome for patients. Fenugreek seed powder has long been known as an anti-diabetic drug since its pharmaceutical properties were demonstrated. Materials: The study herein was a parallel, randomized controlled clinical trial consisting of 60 adult patients randomly divided into 2 groups (n=30 per group). The study was conducted in Sabzevar, Iran in April 2015. The intervention group received 3 g of fenugreek seed powder by gavage, twice a day, in addition to routine care. The control group received only routine care. In the beginning, a daily evaluation of fasting and postprandial blood sugar was conducted for 10 days. Secondary components (prevalence of pneumonia; length of intensive care unit (ICU) stay, length of hospital stay, ventilator days, APACHE II score, and mortality rate) were measured until the time of hospital discharge or death. Data were analyzed via SPSS v.20 using Student's t-test (paired and unpaired), chi-square test, repeated measure ANOVA, and Wilcoxon test. Results: In during 10 days of treatment, there was a significant fall in mean glucose levels in 2 groups. However, this improve was more significant in Intervention group in compared to control group (p<0.001). Conclusion: The present study suggests that daily diet with fenugreek seeds can be used as an add-on therapy with other medications in the management of SIH in critically ill patients.

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To study the efficacy and tolerability of fenugreek seed powder as add-on therapy with metformin in patients of type-2 diabetes mellitus

Cited by 11 publications

References 11 publications

Prebiotic prophylaxis of ventilator-associated pneumonia: A randomized clinical trial

Prebiotic prophylaxis of ventilator-associated pneumonia: A randomized clinical trial

Effects of fenugreek seed powder on enteral nutrition tolerance and clinical outcomes in critically ill patients: A randomized clinical trial

Effects of fenugreek seed powder on stress-induced hyperglycemia and clinical outcomes in critically ill patients: A randomized clinical trial

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