To study the effect of injection dexmedetomidine for prevention of pain due to propofol injection and to compare it with injection lignocaine

Sapate, Manisha; Andurkar, Ujjwala; Markandeya, Mugdha; Gore, Rajesh; Thatte, W. S.

doi:10.1016/j.bjane.2013.10.008

Cited by 13 publications

(14 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The analgesic effect of lignocaine may occur because of a local anaesthetic effect or an inhibitory effect on the enzymatic cascade which leads to release of kinin. 8 Different concentrations of lignocaine were used in different studies. Optimal dose of lidocaine using control, 20 mg, 30 mg and 40 mg lidocaine was studied.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Lignocaine, Pethidine, Ketamine and Placebo for Prevention of Pain on Propofol Injection

2021

View full text Add to dashboard Cite

Background: Pain caused by propofol injection is a common occurrence. Aims and Objectives: The aim of this study was to compare and evaluate the efficacy of three drugs, lignocaine, pethidine and ketamine for prevention of pain during propofol injection. Materials and Methods: This double blind, placebo-controlled, parallel multi-arm study was done after written informed consent and ethics clearance. Hundred patients of ASA I and II, 18-65 years of age, and with body mass index 18-30 kg/m2 were included. Exclusion criteria were significant cardiovascular or hepatic diseases, renal insufficiency, and a history of allergy to the study drugs. Group A (Normal Saline), Group B (Ketamine 25 mg), Group C (Lignocaine 20 mg) and Group D (Pethidine 25 mg) were pre-treated with 2 ml of the study agents before propofol injection. The primary outcome was the incidence of pain with propofol injection and the secondary outcomes were the induction time, pain scores at various time intervals, the incidence of recall of pain after surgery, haemodynamic changes and adverse effects. Results: There were highly significant differences (p<0.001) in the incidences of pain during propofol injection in group A and the other three groups. The difference in incidence of pain was also significant between Group C and other groups. The differences in the pain scores (p<0.001) and recall of pain (p<0.05) between group A and the other three groups were significant. Conclusion: Lidocaine may be considered as a good choice for the purpose of reduction of pain during propofol injection.

show abstract

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Lignocaine, Pethidine, Ketamine and Placebo for Prevention of Pain on Propofol Injection

2021

View full text Add to dashboard Cite

show abstract

“…The increase in the local vein permeability and dilation may be due to the lipid solvent of propofol activating the plasma kallikrein-kinin system leading to release of bradykinin, which further intensifies the propofol injection pain. 7,[11][12][13] However, Ando et al 14 were of the opinion that propofol causes vascular pain that occurs in response to prostanoids, particularly PG E 2 .…”

Section: Discussionmentioning

confidence: 99%

“…The study drug was prepared by a colleague not involved in the study by diluting the drug with normal saline. A pneumatic tourniquet at 70 mm Hg was applied to achieve venous occlusion of the forearm 7 and ketamine was injected over 10 seconds. Then, the tourniquet was removed and the first 25% of the calculated dose (2.5 mg/kg) of propofol was injected over 20 seconds.…”

Section: Methodsmentioning

confidence: 99%

Low dose ketamine pretreatment for alleviation of propofol injection pain- A study

2020

IJCA

View full text Add to dashboard Cite

Introduction: One of the most important disadvantages of propofol injection is intense burning pain. The present study was conducted with the aim to assess the effect of low dose Ketamine (100 µg/kg) in the alleviation of pain on propofol injection. Materials and Methods: Patients who underwent surgical procedures under general anaesthesia were allocated into two groups viz. Group K (n=35) -pre-treatment with ketamine 100µg/kg (1ml) and Group S (n=35)-pre-treatment with 0.9% normal saline (1ml) in this double-blinded, randomized study. After venous occlusion, ketamine was injected over 10 seconds, after which the occlusion was removed and over 20 seconds, the first 25% of the calculated dose of propofol was injected. The evaluation of the severity of pain was done by the verbal rating scale (VRS) during the injection of the induction agent for every 5 seconds and graded as 0 to 3.The data were recorded and analysedusing unpaired't' test and chi-square test as and where appropriate. Results:The demographic profiles were comparable between the two groups. It was observed that 42.9% of patients in normal saline and 80% in ketamine groups experienced no pain (p<0.05) while 31.4% and 17.1% of patients in normal saline and in ketamine groups respectively felt mild pain. No significant haemodynamic changes were observed in both the groups (p>0.05). Conclusion: It may be concluded that pre-treatment with low dose ketamine with a tourniquet just before propofol injection, significantly reduced the incidence and degree of propofol induced pain without significant adverse hemodynamic effects.

show abstract

“…[ 9 ] We observed a higher overall incidence of PIP as compared to other authors with dexmedetomidine. [ 6 10 ] This might be due to the pertinent difference in our study design consisting of slow IV administration of dexmedetomidine without venous occlusion. The venous occlusion slows the systemic release of the drug thereby allowing the analgesics to act upon the endothelial nociceptors, the key site of local anti-nociceptive action.…”

Section: Discussionmentioning

confidence: 99%

“…[ 19 ] Sapate et al in their study to compare dexmedetomidine with lignocaine to alleviate the PIP used IV bolus as the mode of dexmedetomidine administration. [ 10 ] However, they utilised a lower dose of 0.2 μg/kg along with venous occlusion to prevent/slow the systemic release. Rapid IV bolus injection of dexmedetomidine is associated with biphasic BP response with initial hypertension (α-2B adrenoceptor mediated) followed by prolonged hypotension (α-2A adrenergic receptor mediated), bradycardia and even sinus arrest.…”

Section: Discussionmentioning

confidence: 99%

Dexmedetomidine versus ketamine infusion to alleviate propofol injection pain: A prospective randomized and double-blind study

et al. 2015

View full text Add to dashboard Cite

Background and Aims:The use of propofol as the most common induction agent and the high prevalence of propofol injection pain (PIP) highlight the significance of finding the ideal combination of drug, dosage and mode of administration of premedicants to alleviate PIP. A number of bolus drugs with variable efficacy have been studied to reduce PIP. The aim of our study was to assess the efficacy of single dose intravenous (IV) infusion of dexmedetomidine 0.5 μg/kg compared with ketamine 0.5 mg/kg to alleviate PIP.Methods:In this prospective, randomised and double-blind study, 108 patients undergoing elective surgeries under general anaesthesia were randomly allocated to two groups: Group D to receive dexmedetomidine 0.5μg/kg or Group K to receive ketamine 0.5 mg/kg in 20 ml of normal saline over 10 min. Immediately after the infusion, 1% propofol 2 mg/kg IV was injected over 25 s. The patients were assessed for pain every 5 s by asking the question ‘does it hurt?’ until the loss of consciousness. The pain scoring was done using McCririck and Hunter scale. Statistical analysis was done using SPSS 17.0.Results:The incidence of PIP and moderate-severe PIP was higher with Group D (79.6%; 16.7%) compared with Group K (40.7; 1.9%) (P < 0.001; 0.016). No patient in either group had arm withdrawal upon propofol injection. The incidence of hypertension and tachycardia was statistically significant in Group K as compared to Group D (P = 0.027).Conclusion:There was no difference in elimination of the arm withdrawal response and in incidence of moderate to severe PIP between the groups.

show abstract

To study the effect of injection dexmedetomidine for prevention of pain due to propofol injection and to compare it with injection lignocaine

Cited by 13 publications

References 11 publications

A Comparative Study of Lignocaine, Pethidine, Ketamine and Placebo for Prevention of Pain on Propofol Injection

A Comparative Study of Lignocaine, Pethidine, Ketamine and Placebo for Prevention of Pain on Propofol Injection

Low dose ketamine pretreatment for alleviation of propofol injection pain- A study

Dexmedetomidine versus ketamine infusion to alleviate propofol injection pain: A prospective randomized and double-blind study

Contact Info

Product

Resources

About