To study physical compatibility between dibasic calcium phosphate and cohesive actives using powder rheometer and thermal methods

Abstract

Binary mixtures of DCP's were prepared by addition of 0% w/w to 50% w/w of the API in each powder blend. Powder rheological analysis were conducted using FT4 powder rheometer, rotational shear cell and empirical approaches such as angle of repose (AOR), Hausner ratio (HR) and Carr's index (CI). Thermal analysis was conducted using differential scanning calorimetry (DSC) and thermal effusivity. Morphological studies were conducted using Scanning Electron Microscopy (SEM) to determine the fundamental differences between powder materials. Result/Conclusions: Powder rheometer showed distinctive understanding in the flowability behavior of binary mixtures with addition of increasing proportion of API's than empirical approaches. Thermal approaches revealed the potential interaction of water of crystallization DCP-D while such interaction was absent in DCP-A. Binary mixtures prepared using DCP-D were better flowable while blends containing DCP-A were better in stability (physical), compressibility and permeability. This study allows the scientist to understand the powder packing of different blends with their flowability and compressibility parameter and helps selection of appropriate form of hydrate for relevant API.

To Evaluate the Effect of Solvents and Different Relative Humidity Conditions on Thermal and Rheological Properties of Microcrystalline Cellulose 101 Using METHOCEL™ E15LV as a Binder

“…With the advancement in technology, new methods such as shear cell (30,31), avalanche testing (32), cohesivity determination (33), torque rheometer (34), penetrometry (35), atomic force microscopy (36), and powder rheometer (37) have been successfully used, but no specific method has still been standardized for the assessment of powder flow properties. Powder rheometer has shown reproducible and acceptable results in measuring the dynamic, bulk, and shear properties of powders (38,39).…”

A Quantitative Approach to Understand Raw Material Variability

“…The permeability of a granular material is influenced by particle properties such as size, shape, surface texture, and stiffness as well as bulk properties such as cohesion and bulk density. Permeability is typically measured as the pressure drop across a powder bed over a range of consolidation states, as achieved by the FT4 from Freeman Technology [37]. A schematic of the test and sample raw data that can be obtained are shown below in Fig.…”