To RNA‐binding and beyond: Emerging facets of the role of Rbfox proteins in development and disease
Amartya Mukherjee,
Upendra Nongthomba
Abstract:The RNA‐binding Fox‐1 homologue (Rbfox) proteins represent an ancient family of splicing factors, conserved through evolution. All members share an RNA recognition motif (RRM), and a particular affinity for the GCAUG signature in target RNA molecules. The role of Rbfox, as a splice factor, deciding the tissue‐specific inclusion/exclusion of an exon, depending on its binding position on the flanking introns, is well known. Rbfox often acts in concert with other splicing factors, and forms splicing regulatory ne… Show more
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