To Investigate the Occurrence and Development of Colorectal Cancer Based on the PI3K/AKT/mTOR Signaling Pathway

Zhong, Jian‐Jiang; Ding, Shuang; Zhang, Xinyu; Di, Wenyu; Wang, Xiaohui; Zhang, Hui; Chen, Yiyang; Zhang, Yongxi; Hu, Yuhan

doi:10.31083/j.fbl2802037

Cited by 13 publications

(11 citation statements)

References 129 publications

(130 reference statements)

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“…Accumulated evidence revealed the importance of the PI3K/AKT/mTOR pathway in tumorigenesis, proliferation, and progression in CRC. [34][35][36] In conclusion, CRC exhibit significantly different m1A modifica-…”

Section: M1a Score Associated With Crc Prognosismentioning

confidence: 84%

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Landscape of N1‐methyladenosin (m1A) modification pattern in colorectal cancer

Jiang,

Tian,

et al. 2023

Cancer Reports

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BackgroundN1‐methyladenosine (m1A) is a recently identified mRNA modification. However, it is still unclear that how m1A alteration affects the development of colorectal cancer (CRC).AimsThe landscape of m1A modification patterns regarding tumor immune microenvironment (TIME) in CRC is a lack of knowledge. Thus, this study will utilize the public database to comprehensively evaluate of multiple m1A methylation regulators in CRC.Methods and resultsWe retrospectively analyzed 398 patients with CRC and 39 healthy people for negative control, using the The Cancer Genome Atlas (TCGA) database to evaluate m1A modification patterns regarding tumor immune microenvironment (TIME) in CRC. The m1Ascore was developed via principal component analysis. And its clinical value in prognosis of CRC was further explored. Our study revealed 12 key m1A‐related DEGs including CLDN3, MUC2 and CCDC85B which are identified associated with invasion and metastasis in CRC. The most important biological processes linked to weak immune response and poor prognosis were the regulation of RNA metabolism and RNA biosynthesis. Furthermore, we found that compared to patients with low m1A scores, those with high m1A scores had higher percentage, larger tumor burdens, and worse prognosis.ConclusionSignificantly diverse m1A modification patterns can be seen in CRC. Through its impact on TIME and immunological dysfunction, the heterogeneity of m1A alteration patterns influences the prognosis of CRC. This study provided novel insights into the m1A modification in CRC which might promote the development of personalized immunotherapy strategies.

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Section: M1a Score Associated With Crc Prognosismentioning

confidence: 84%

“…The phosphatidylinositol 3‐kinase (PI3K)/AKT pathway serves as the upper axis of the mTOR pathway. Accumulated evidence revealed the importance of the PI3K/AKT/mTOR pathway in tumorigenesis, proliferation, and progression in CRC 34–36 …”

Section: Discussionmentioning

confidence: 99%

Landscape of N1‐methyladenosin (m1A) modification pattern in colorectal cancer

Jiang,

Tian,

et al. 2023

Cancer Reports

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“…In CRC, mTOR significantly regulates proliferation, survival, growth, differentiation, and autophagy. 80 The PI3K/AKT/mTOR pathway is an intracellular signaling pathway composed of different kinases.…”

Section: Signaling Pathway In Angiogenesismentioning

confidence: 99%

“…Common in CRC, overactivation of mTOR signaling is strongly related to cancer progression, initiation, and DR. In CRC, mTOR significantly regulates proliferation, survival, growth, differentiation, and autophagy 80 . The PI3K/AKT/mTOR pathway is an intracellular signaling pathway composed of different kinases.…”

Section: Angiogenesis and Colorectal Cancermentioning

confidence: 99%

Anti‐angiogenesis in colorectal cancer therapy

Yang,

Zhang,

Bai

et al. 2024

Cancer Science

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The morbidity of colorectal cancer (CRC) has risen to third place among malignant tumors worldwide. In addition, CRC is a common cancer in China whose incidence increases annually. Angiogenesis plays an important role in the development of tumors because it can bring the nutrients that cancer cells need and take away metabolic waste. Various mechanisms are involved in the formation of neovascularization, and vascular endothelial growth factor is a key mediator. Meanwhile, angiogenesis inhibitors and drug resistance (DR) are challenges to consider when formulating treatment strategies for patients with different conditions. Thus, this review will discuss the molecules, signaling pathways, microenvironment, treatment, and DR of angiogenesis in CRC.

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“…PI3Ks are intracellular lipid kinases involved in the regulation of cell proliferation, differentiation and survival, that promote cell growth by inhibiting apoptosis in colorectal cancer cells and influences the effectiveness of chemotherapeutic agents ( 46 ).…”

Section: Role Of β-Catenin In the Transformation Of Precancerous Lesi...mentioning

confidence: 99%

Chemoprophylaxis of precancerous lesions in patients who are at a high risk of developing colorectal cancer (Review)

Ogurchenok,

Khalin,

Bryukhovetskiy

2024

Med Int

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The diagnostics of colorectal cancer (CRC) and precancerous lesions in the colon is one of the most urgent matters to be considered for the modern protocols of complex examination, recommended for use from the age of 45 years, and including both instrumental and laboratory methods of research: Colonoscopy, CT colonography, flexible sigmoidoscopy, fecal occult blood test, fecal immunohistochemistry test and stool DNA test Nevertheless, the removal of those precancerous lesions does not solve the issue, and, apart from the regular endoscopic monitoring of patients who are at a high risk of developing CRC, the pharmacological treatment of certain key pathogenic mechanisms leading to the development of CRC is required. The present review to discusses the function of β-catenin in the transformation of precancerous colorectal lesions into CRC, when collaborating with PI3K/AKT/mTOR signaling pathway and other mechanisms. The existing methods for the early diagnostics and prevention of discovered anomalies are described and categorized. The analysis of the approaches to chemoprophylaxis of CRC, depending on the results of endoscopic, morphological and molecular-genetic tests, is presented.

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To Investigate the Occurrence and Development of Colorectal Cancer Based on the PI3K/AKT/mTOR Signaling Pathway

Cited by 13 publications

References 129 publications

Landscape of N1‐methyladenosin (m1A) modification pattern in colorectal cancer

Landscape of N1‐methyladenosin (m1A) modification pattern in colorectal cancer

Anti‐angiogenesis in colorectal cancer therapy

Chemoprophylaxis of precancerous lesions in patients who are at a high risk of developing colorectal cancer (Review)

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