To investigate the efficacy of topical application of heparin sodium, benzyle nicotinate and nifedipine paste in external thrombosed prolapsed haemorrhoids

Abstract

Eighty-six patient (49males, 37 females) with acute thrombosed external prolapsed haemorrhoids from January 2019 to January 2022 were treated topically with heparin sodium plus benzyl nicotinate along with 0.5% nifedipine ointment paste (t.i.d.) for 8 wk. All the patients were advised to take a high-fibre diet and assessed post-treatment at 2, 4 and 8 weeks. The healing of external thrombosed haemorrhoids and any side effects were recorded. The patients were again followed up subsequently in the outpatient department for the period of 2years and contacted by phone every three months thereafter, while they were encouraged to come back if symptoms recurred. Seventy-nine of the 86 patients followed the instruction regularly and completed the 8-wk treatment course, of them 77 patients (85.2%) achieved a complete remission indicated by resolution of pain and swellings symptoms and resolution of the thrombosis of haemorrhoids. Of the remaining nine unhealed patients (14.8%), 5 opted to undergo haemorrhoidectomy and the other 4 to continue therapy for four additional weeks, resulting in healing and resolution of pain and swellings symptoms and resolution of the thrombosis of haemorrhoids.