To initiate or not to initiate: A critical assessment of eIF2A, eIF2D, and MCT‐1·DENR to deliver initiator tRNA to ribosomes
Daisy J. Grove,
Paul J. Russell,
Michael G. Kearse
Abstract:Selection of the correct start codon is critical for high‐fidelity protein synthesis. In eukaryotes, this is typically governed by a multitude of initiation factors (eIFs), including eIF2·GTP that directly delivers the initiator tRNA (Met‐tRNAiMet) to the P site of the ribosome. However, numerous reports, some dating back to the early 1970s, have described other initiation factors having high affinity for the initiator tRNA and the ability of delivering it to the ribosome, which has provided a foundation for f… Show more
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