To incise or not and where: SET-domain methyltransferases know

Yancoskie, Michelle N.; Maritz, Corina; Eijk, Patrick van; Reed, Simon H.; Naegeli, Hanspeter

doi:10.1016/j.tibs.2022.10.003

Cited by 2 publications

(4 citation statements)

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“…H3K4me3 modification frequently accumulates at the promoters of active genes and is generally known as a histone modification associated with transcriptional activation 34 . There are also H3K4me3 not associated with transcriptional activation, 35,36 and their contribution to the specific three‐dimensional architecture of the genome involving various chromatin remodeling factors, transcription factors, and DNA‐cleaving enzymes, and so on has been reported 37 . These three‐dimensional structures include not only those associated with transcriptional activation but also those associated with DNA recombination and repair 37 …”

Section: Histone Modificationsmentioning

confidence: 99%

“…34 There are also H3K4me3 not associated with transcriptional activation, 35,36 and their contribution to the specific three-dimensional architecture of the genome involving various chromatin remodeling factors, transcription factors, and DNA-cleaving enzymes, and so on has been reported. 37 These three-dimensional structures include not only those associated with transcriptional activation but also those associated with DNA recombination and repair. 37 In 2019, Xia et al 38 reported a comprehensive study of H3K4me3 and H3K27me3 methylome in human oocytes and preimplantation embryos using CUT&RUN.…”

Section: Exploring the Genome-wide H3k4me3 Landscape Of Preimplantati...mentioning

confidence: 99%

“…37 These three-dimensional structures include not only those associated with transcriptional activation but also those associated with DNA recombination and repair. 37 In 2019, Xia et al 38 reported a comprehensive study of H3K4me3 and H3K27me3 methylome in human oocytes and preimplantation embryos using CUT&RUN. Based on the changes in H3K4me3 in humans through preimplantation development they revealed (Figure 2), let us look at the similarities and differences with the previously reported murine cases.…”

Section: Exploring the Genome-wide H3k4me3 Landscape Of Preimplantati...mentioning

confidence: 99%

“… 37 These three‐dimensional structures include not only those associated with transcriptional activation but also those associated with DNA recombination and repair. 37 …”

Section: Histone Modificationsmentioning

confidence: 99%

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Current status of genome‐wide epigenetic profiling of mammalian preimplantation embryos

Ikeda

2023

Reprod Medicine & Biology

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BackgroundGenome‐wide information on epigenetic modifications in mammalian preimplantation embryos was an unexplored sanctuary of valuable research insights protected by the difficulty of its analysis. However, that is no longer the case, and many epigenome maps are now available for sightseeing there.MethodsThis review overviews the current status of genome‐wide epigenetic profiling in terms of DNA methylome and histone modifications in mammalian preimplantation embryos.Main findingsAs the sensitivity of methods for analyzing epigenetic modifications increased, pioneering work began to explore the genome‐wide epigenetic landscape in the mid‐2010s, first for DNA methylation and then for histone modifications. Since then, a huge amount of data has accumulated, revealing typical epigenetic profiles in preimplantation development and, more recently, changes in response to environmental interventions.ConclusionsThese accumulating data may be used to improve the quality of preimplantation embryos, both in terms of their short‐term developmental competence and their subsequent long‐term health implications.

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Section: Histone Modificationsmentioning

confidence: 99%

Section: Exploring the Genome-wide H3k4me3 Landscape Of Preimplantati...mentioning

confidence: 99%

Section: Exploring the Genome-wide H3k4me3 Landscape Of Preimplantati...mentioning

confidence: 99%

“… 37 These three‐dimensional structures include not only those associated with transcriptional activation but also those associated with DNA recombination and repair. 37 …”

Section: Histone Modificationsmentioning

confidence: 99%

See 2 more Smart Citations