To fit or not to fit: death decisions from morphogen fields

Merino, Marisa M.; González‐Gaitán, Marcos

doi:10.1016/j.tcb.2022.09.003

Cited by 3 publications

(5 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Genetic studies have shown that Dally is required to establish a Dpp gradient in the wing disk, and that the levels of Dpp are significantly reduced in clones that lack Dally. [57][58][59] Additional studies demonstrated that Dally regulates the Dpp gradient by stabilizing this morphogen on the cell surface, and delaying the degradation of the Dpp-Dpp receptor complexes with the consequent signal enhancement. 25 Dpp plays a key role in the regulation of germ line differentiation in the stem cell niche of the Drosophila ovary.…”

Section: Two Glypicans Have Been Identified In Caenorhabditis Elegansmentioning

confidence: 98%

“…The morphogen Dpp, a Drosophila BMP, promotes the growth of the wing disc during development. Genetic studies have shown that Dally is required to establish a Dpp gradient in the wing disk, and that the levels of Dpp are significantly reduced in clones that lack Dally 57–59 . Additional studies demonstrated that Dally regulates the Dpp gradient by stabilizing this morphogen on the cell surface, and delaying the degradation of the Dpp‐Dpp receptor complexes with the consequent signal enhancement 25 …”

Section: Glypican Functionmentioning

confidence: 99%

See 1 more Smart Citation

Glypicans, 35 years later

Filmus

2023

Proteoglycan Research

View full text Add to dashboard Cite

Glypicans are a family of proteoglycans that are bound to the cell surface by a glycosylphosphatidylinositol anchor. These proteoglycans are highly conserved during evolution, and the mammalian genome contains six members of the family.Glypicans carry two to four heparan sulfate chains that are inserted near the carboxy terminus. The crystal structure reveals a densely packed cylindrical shape that is parallel to the cell surface. The functions of glypicans are mediated by the heparan sulfate chains and/or the core protein. One of the main functions of these proteoglycans is the regulation of the signaling pathways triggered by hedgehogs, Wnts, fibroblast growth factors, and bone morphogenetic proteins. Glypicans can either stimulate or inhibit the interaction of these growth factors with their signaling receptors. Studies in Drosophila have also shown that glypicans can regulate hedgehog, Wnt, and bone morphogenetic factor gradient formation. In addition, glypicans play important roles in the establishment of synapses and in neuron guidance and migration. Glypican mutations cause several developmental syndromes, and overexpression of these proteins contribute to the progression of various cancer types. In particular, glypican-3 is currently being used as a marker for the diagnosis of hepatocellular carcinomas, and it is being targeted by several immunotherapeutic approaches for the treatment of this malignancy.

show abstract

Section: Two Glypicans Have Been Identified In Caenorhabditis Elegansmentioning

confidence: 98%

Section: Glypican Functionmentioning

confidence: 99%

Glypicans, 35 years later

Filmus

2023

Proteoglycan Research

View full text Add to dashboard Cite

show abstract

Section: Cell Competition In Primary and Secondary Cancer Growthmentioning

confidence: 99%

“…In the literature, a great number of studies show that the bases of these competitive behaviours are of different natures [ 14 , 41 , 62 , 63 , 69 , 71 , 72 , 73 , 77 , 81 , 87 , 88 , 89 ]. Cells can battle for growth factors and also space; furthermore, signalling levels and growth rates seem to play a big role in the game [ 62 , 65 , 69 , 77 , 81 , 87 , 88 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 ]. For instance, during organ growth in Drosophila, and in vertebrates, cells with “wrong” morphogen signalling levels are eliminated from the growing field in order to maintain wild-type size or pattern [ 87 , 88 , 99 ].…”

Section: Cell Competition In Primary and Secondary Cancer Growthmentioning

confidence: 99%

“…That is, the Dpp gradient scales with tissue size [ 116 , 120 ]. To fulfil this job, there is a mechanism which tunes the

during organ growth, keeping the gradient and tissue proportional [ 87 , 88 , 116 , 125 , 126 , 127 ]. In this particular organ (i.e., wing), Dpp signalling scaling failure leads to defects in tissue size and pattern formation [ 87 , 88 , 116 , 126 , 128 , 129 ].…”

Section: Scaling Phenomena During Development Adulthood and Tumorigen...mentioning

confidence: 99%

See 1 more Smart Citation

Stemming Tumoral Growth: A Matter of Grotesque Organogenesis

Merino

García‐Sanz

2023

Cells

View full text Add to dashboard Cite

The earliest metazoans probably evolved from single-celled organisms which found the colonial system to be a beneficial organization. Over the course of their evolution, these primary colonial organisms increased in size, and division of labour among the cells became a remarkable feature, leading to a higher level of organization: the biological organs. Primitive metazoans were the first organisms in evolution to show organ-type structures, which set the grounds for complex organs to evolve. Throughout evolution, and concomitant with organogenesis, is the appearance of tissue-specific stem cells. Tissue-specific stem cells gave rise to multicellular living systems with distinct organs which perform specific physiological functions. This setting is a constructive role of evolution; however, rebel cells can take over the molecular mechanisms for other purposes: nowadays we know that cancer stem cells, which generate aberrant organ-like structures, are at the top of a hierarchy. Furthermore, cancer stem cells are the root of metastasis, therapy resistance, and relapse. At present, most therapeutic drugs are unable to target cancer stem cells and therefore, treatment becomes a challenging issue. We expect that future research will uncover the mechanistic “forces” driving organ growth, paving the way to the implementation of new strategies to impair human tumorigenesis.

show abstract

Azot expression in the Drosophila gut modulates organismal lifespan

Merino

2022

Communicative & Integrative Biology

View full text Add to dashboard Cite

Cell Competition emerged in Drosophila as an unexpected phenomenon, when confronted clones of fit vs unfit cells genetically induced. During the last decade, it has been shown that this mechanism is physiologically active in Drosophila and higher organisms. In Drosophila , Flower (Fwe) eliminates unfit cells during development, regeneration and disease states. Furthermore, studies suggest that Fwe signaling is required to eliminate accumulated unfit cells during adulthood extending Drosophila lifespan. Indeed, ahuizotl ( azot ) mutants accumulate unfit cells during adulthood and after physical insults in the brain and other epithelial tissues, showing a decrease in organismal lifespan. On the contrary, flies carrying three functional copies of the gene, unfit cell culling seems to be more efficient and show an increase in lifespan. During aging, Azot is required for the elimination of unfit cells, however, the specific organs modulating organismal lifespan by Azot remain unknown. Here we found a potential connection between gut-specific Azot expression and lifespan which may uncover a more widespread organ-specific mechanism modulating organismal survival.

show abstract

To fit or not to fit: death decisions from morphogen fields

Cited by 3 publications

References 13 publications

Glypicans, 35 years later

Glypicans, 35 years later

Stemming Tumoral Growth: A Matter of Grotesque Organogenesis

Azot expression in the Drosophila gut modulates organismal lifespan

Contact Info

Product

Resources

About