To Evaluate the Effect of Chronic Obstructive Pulmonary Disease on Retinal and Choroidal Thicknesses Measured by Optical Coherence Tomography

Alim, Sait; Demir, Helin Deniz; Yılmaz, Ayşe; Demir, Selim; Güneş, Alper

doi:10.1155/2019/7463815

Cited by 7 publications

(6 citation statements)

References 25 publications

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“…have found no significant difference between the COPD patients and the control group in terms of CMT. [ 3 9 ] The CMT values obtained in the current work are attributed to the active autoregulatory mechanisms in the retinal circulation. [ 14 ] In addition, compared with choroidal circulation the retinal circulation is more sensitive to blood PaO 2 levels and responds to changes in blood oxygen levels more rapidly and actively to protect the central retinal functions.…”

Section: Discussionmentioning

confidence: 74%

“…[ 10 ] Similarly, Alim et al . [ 3 ] reported that the severe COPD patients demonstrated significantly reduced SCFT compared with the healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous studies have investigated the effects of chronic hypoxia on retinal and choroidal circulation in the course of chronic diseases, such as obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD). [ 3 4 5 6 7 8 9 10 ] In addition, we have encountered case series evaluating the effects of acute high-altitude exposure on ocular microcirculation. Currently, no study has evaluated choroidal thickness in healthy individuals living at high altitudes.…”

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confidence: 99%

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Evaluation of macular and choroidal thickness in healthy residents living at high altitude

Gök¹,

Karaman²,

Erdem

2022

Indian Journal of Ophthalmology

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Purpose: Assessment of long-term effects of high altitude on choroidal thickness. Methods: This prospective cross-sectional study included 88 and 79 age- and sex-matched healthy individuals who were living at sea-level (SL group) and high-altitude (HA group), respectively. Participants were required to have resided in the same place for at least 10 years. Spectral-domain optical coherence tomography (SD-OCT) scans were conducted in two different and were performed within the same time (08:00 am to 10:00 am). Central macular thickness (CMT) and choroidal thickness were measured at five different points (i.e., at the central fovea and 1 mm and 2 mm temporal and nasal of the fovea). Blood hemoglobin (Hb), red blood cell (RBC), hematocrit (Htc) levels, blood oxygen saturation, heart rate, and body mass index (BMI) were compared between groups statistically. Results: The HA group had a mean age of 47.5 ± 13.3 years, whereas the SL group was 48.7 ± 13.4 years ( P = 0.57). There was no significant difference between the groups in terms of CMT. Subfoveal choroidal thickness (SCFT) was 282.73 ± 87.82 mm in the HA group and 310.49 ± 74.73 in the SL group ( P = 0.02). The choroid was found to be thinner at all the measured locations in the HA group except the 2 mm nasal point of the fovea. However, only the difference at an SFCT was statistically significant. Furthermore compared with the SL group statistically significant higher Hb, RBC, Htc levels were determined in the HA group. In the multiple linear regression model analysis, age was found an only effective confounder factor for SCFT ( P = 0.001, 95% CI 4.132–2.476). Conclusion: The systemic adaptive changes due to chronic high altitude exposure may cause structural changes in the choroidal vascular network. The current study results revealed significant thinning only at SFCT. Large-scale longitudinal studies are needed to obtain more definitive data on this subject.

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Section: Discussionmentioning

confidence: 74%

“…[ 10 ] Similarly, Alim et al . [ 3 ] reported that the severe COPD patients demonstrated significantly reduced SCFT compared with the healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Evaluation of macular and choroidal thickness in healthy residents living at high altitude

Gök¹,

Karaman²,

Erdem

2022

Indian Journal of Ophthalmology

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“…Corroboratory genetic evidence for this was also observed, with genetic predisposition to lower FEV1 and FVC being associated with thinner RNFL and PS layers. Thinning of the RNFL and choroid have been associated with COPD in a number of cross-sectional studies (81)(82)(83)(84)(85). OCT studies in the context of infectious pneumonia are few in number and mostly relate to SARS-CoV-2 (COVID-19), which is variably reported to be associated with reduced macular thickness and RNFL thinning (86), as well as increased RNFL and GCC thickness compared to controls (87).…”

Section: Discussionmentioning

confidence: 99%

Insights into human health from phenome- and genome-wide analyses of UK Biobank retinal optical coherence tomography phenotypes

Zekavat,

Jorshery,

Shweikh

et al. 2023

Preprint

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The human retina is a complex multi-layered tissue which offers a unique window into systemic health and disease. Optical coherence tomography (OCT) is widely used in eye care and allows the non-invasive, rapid capture of retinal measurements in exquisite detail. We conducted genome- and phenome-wide analyses of retinal layer thicknesses using macular OCT images from 44,823 UK Biobank participants. We performed phenome-wide association analyses, associating retinal thicknesses with 1,866 incident ICD-based conditions (median 10-year follow-up) and 88 quantitative traits and blood biomarkers. We performed genome-wide association analyses, identifying inherited genetic markers which influence the retina, and replicated our associations among 6,313 individuals from the LIFE-Adult Study. And lastly, we performed comparative association of phenome- and genome- wide associations to identify putative causal links between systemic conditions, retinal layer thicknesses, and ocular disease. Independent associations with incident mortality were detected for photoreceptor thinning and ganglion cell complex thinning. Significant phenotypic associations were detected between retinal layer thinning and ocular, neuropsychiatric, cardiometabolic and pulmonary conditions. Genome-wide association of retinal layer thicknesses yielded 259 loci. Consistency between epidemiologic and genetic associations suggested putative causal links between thinning of the retinal nerve fiber layer with glaucoma, photoreceptor segment with AMD, as well as poor cardiometabolic and pulmonary function with PS thinning, among other findings. In conclusion, retinal layer thinning predicts risk of future ocular and systemic disease. Furthermore, systemic cardio-metabolic-pulmonary conditions promote retinal thinning. Retinal imaging biomarkers, integrated into electronic health records, may inform risk prediction and potential therapeutic strategies.

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“…Choroidal thinning in patients with COPD is due to decreased choroidal blood flow and decreased ocular perfusion pressure [24]. The chronic inflammation and hypoxia in subjects with COPD may lead to an increase in the diameter of the retinal veins, impaired hemodynamics, lower retinal arterial oxygen saturation causing thinning of the retinal nerve fiber layer, and subfoveal choroidal thickness [25,26].…”

Section: Chronic Obstructive Pulmonary Diseasementioning

confidence: 99%

Ocular manifestations of common pulmonary diseases - A narrative review

Singh

Deokar

Sinha

et al. 2023

Monaldi Arch Chest Dis

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Ocular involvement can be a comorbidity of several pulmonary disorders. A knowledge of these manifestations is essential for early diagnosis and treatment. Hence, we aimed to review the common ocular manifestations of Asthma, COPD, sarcoidosis, obstructive sleep apnea and lung cancer. The ocular manifestations of bronchial asthma include allergic keratoconjunctivitis and dry eye. The inhaled corticosteroids used in the management of asthma can lead to cataract formation. COPD is associated with ocular microvascular changes due to chronic hypoxia and spill over of systemic inflammation into the eyes. However, its clinical significance is yet to be known. Ocular involvement is very common in sarcoidosis, seen in 20% of cases of pulmonary sarcoidosis. It can involve almost any anatomical structure of the eye. Studies have shown the association of obstructive sleep apnea (OSA) with floppy eye syndrome, glaucoma, nonarteritic anterior ischemic optic neuropathy, keratoconus, retinal vein occlusion and central serous retinopathy. However, though association has been established, causality remains to be proven. The effect of positive airway pressure (PAP) therapy used in the treatment of OSA on the above ocular conditions is yet to be known. The PAP therapy can itself lead to irritation and dry eyes. Lung cancer can involve the eyes by direct invasion of nerves, ocular metastasis or as a part of paraneoplastic syndrome. The purpose of this narrative review is to raise awareness about the association between ocular and pulmonary disorders to facilitate early detection and treatment of these conditions.

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To Evaluate the Effect of Chronic Obstructive Pulmonary Disease on Retinal and Choroidal Thicknesses Measured by Optical Coherence Tomography

Cited by 7 publications

References 25 publications

Evaluation of macular and choroidal thickness in healthy residents living at high altitude

Evaluation of macular and choroidal thickness in healthy residents living at high altitude

Insights into human health from phenome- and genome-wide analyses of UK Biobank retinal optical coherence tomography phenotypes

Ocular manifestations of common pulmonary diseases - A narrative review

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