TO EVALUATE EFFECT OF IV ESMOLOL (1MG/KG) COMPARED TO I.V. LABETALOL (0.5MG/KG) IN ATTENUATING PRESSOR RESPONSE DURING LARYNGOSCOPY & INTUBATION IN GENERAL ANESTHESIA

Abstract

BACKGROUND: Laryngoscopy and endotracheal intubation is invariable in G.A. and is associated with increased sympathomimetic response. The present study compared the efficacy of esmolol and labetalol in low doses for attenuation of pressor response. MATERIALS & METHODS:This is a Prospective, randomized, placebo controlled study in which 75 ASA Grade I and II patients aged 18-45 yrs. undergoing elective surgical procedures, requiring G.A. and orotracheal intubation were taken up for the study. Patients were allocated to any of the three groups of (25 each). Group C (Control) received 10ml of 0.9% saline IV, Group E (Esmolol) were given 1mg/kg of drug diluted with 0.9% saline 10ml IV, Group L (Labetalol) were given 0.5mg/kg of the drug diluted with 0.9% saline 10ml IV. All the patients were subjected to the same anesthesia technique. HR, SBP, DBP were recorded prior to intubation, then 1 minute, 3 min, 5 min and upto 10min post intubation. RESULTS: Compared to placebo, esmolol and labetalol significantly attenuated HR, SBP, DBP during laryngoscopy and intubation. CONCLUSION: In lower doses, labetalol is a better agent than esmolol in attenuating the sympathomimetic response to laryngoscopy and intubation.