To Dye or Not to Dye: A Randomized, Clinical Trial of a Triple Dye/Alcohol Regime Versus Dry Cord Care

Janssen, Patricia A.; Selwood, Barbara L.; Dobson, Simon; Peacock, Donlim; Thiessen, Paul

doi:10.1542/peds.111.1.15

Cited by 94 publications

(57 citation statements)

References 12 publications

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“…Moreover, the agent has been clinically used as an antibacterial agent. In neonatal care, triple dye (a combination of brilliant green, proflavine hemisulfate, and gentian violet) is routinely used as a topical antibacterial agent on the umbilical stump of newborn babies, 28 with a recent review of the practice categorizing toxicity as rare. 29 In this pilot study, the proflavine concentration is significantly lower than that of commercial triple dye, 0.11% (w/v) (Kerr Triple Dye, Vista Pharm, Birmingham, Alabama).…”

Section: Discussionmentioning

confidence: 99%

Modular video endoscopy forin vivocross-polarized and vital-dye fluorescence imaging of Barrett’s-associated neoplasia

et al. 2013

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Abstract. A modular video endoscope is developed and tested to allow imaging in different modalities. This system incorporates white light imaging (WLI), cross-polarized imaging (CPI), and vital-dye fluorescence imaging (VFI), using interchangeable filter modules. CPI and VFI are novel endoscopic modalities that probe mucosal features associated with Barrett's neoplasia. CPI enhances vasculature, while VFI enhances glandular architecture. In this pilot study, we demonstrate the integration of these modalities by imaging areas of Barrett's metaplasia and neoplasia in an esophagectomy specimen. We verify that those key image features are also observed during an in vivo surveillance procedure. CPI images demonstrate improved visualization of branching blood vessels associated with neoplasia. VFI images show glandular architecture with increased glandular effacement associated with neoplasia. Results suggests that important pathologic features seen in CPI and VFI are not visible during standard endoscopic white light imaging, and thus the modalities may be useful in future in vivo studies for discriminating neoplasia from Barrett's metaplasia. We further demonstrate that the integrated WLI/CPI/VFI endoscope is compatible with complementary high-resolution endomicroscopy techniques such as the high-resolution microendoscope, potentially enabling two-step ("red-flag" widefield plus confirmatory high-resolution imaging) protocols to be enhanced. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Discussionmentioning

confidence: 99%

Modular video endoscopy forin vivocross-polarized and vital-dye fluorescence imaging of Barrett’s-associated neoplasia

et al. 2013

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“…20 Cord stumps of all infants were cultured, and community health nurses conducted postdischarge home visits to record signs of infection. Among infants receiving dry care only, bacterial colonization was significantly higher (E. coli, 34.2% vs. 22.1%; coagulase-negative staphylococci, 69.5% vs. 50.5%; GBS, 11.7% vs. 6.0%), particularly with S. aureus, (31.3% vs. 2.8%).…”

Section: Developed Country Studies Umbilical Cord Colonization Studiesmentioning

confidence: 99%

Role of antimicrobial applications to the umbilical cord in neonates to prevent bacterial colonization and infection: a review of the evidence

Mullany

Darmstadt

Tielsch

2003

The Pediatric Infectious Disease Journal

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In developing countries umbilical cord infections constitute a major cause of neonatal morbidity and pose significant risk for mortality, whereas outbreaks of cord infections continue to occur in developed country nurseries. Cord infections in developing countries can be prevented through increasing access to tetanus toxoid immunization during pregnancy, promoting clean cord care and reducing harmful cord applications and behaviors. Interventions introduced in both developed and developing countries to reduce exposure of the cord to infectious pathogens include clean cord cutting, hand-washing before and after handling the baby, bathing of the infant with antimicrobial agents and application of antimicrobials to the cord. Despite the importance of umbilical cord care, both traditionally and medically, there have been few randomized trials investigating the impact of different cord care regimens on rates of local or systemic infections, particularly in developing countries.This review examines available data on umbilical cord care, with a particular focus on those comparing rates of bacterial colonization and/or rates of cord infection among neonates receiving different umbilical cord care regimens. Although most investigators agree that topical antimicrobials reduce bacterial colonization of the cord, a firm relationship between colonization and infection has not been established. Further research in developed countries, including follow-up beyond hospital discharge, is required before advising on "best cord care practices." The paucity of published reports from developing countries indicates the need to investigate the impact of antimicrobial applications on cord and systemic infections in a community-based, prospective manner.

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“…Infection can be prevented by keeping the umbilical cord clean and dry, without applying anything, and this can help the umbilicus to fall off early (11,12). Furthermore, diapers should be fastened below the umbilical cord so that it will not be in contact with urine and faeces.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Knowledge and Attitude Changes of Mothers in Neonatal Care

Hamilçıkan¹,

Polat²,

Can³

et al. 2017

jpr

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ABS TRACT ÖZ Materials and Methods:Questionnaire forms designed on the subject of infant care and nutrition were given to mothers right after delivery. Before being discharged they were informed by the doctor and breastfeeding nurse about nutrition, infant care, and the most common mistakes. These forms were reapplied on the 15 th and 30 th days in neonatal polyclinic controls and the changes were evaluated. The correct information was repeated to the mothers who were detected to have misinformation and wrong attitudes in the evaluations in each form application period. Results: A total of 100 mothers and their infants were included in the study. No difference was determined in the nutrition rates of infants with food other than breast milk on the first day, 15 th and 30 th days. However, the breastfeeding rates obtained were higher on the 30 th day than on the 15 th , with an interval of two hours, and in general breastfeeding rates were low on the 15 th and 30 th days. The rates of bathing the infants with and without a bathtub net were determined to be high on the 15 th and 30 th days. The change in the infants' sleeping positions, the place of sleep, and the presence of rails/guards around the crib on the 15 th and 30 th days were not found to be significant compared to the 1 st day. There was a significant increase in the umbilical care rates on the 15 th and 30 th days. The increase in washing the clothes of the infants with soap powder, and the decrease in swaddling after the education were found to be significant. Furthermore, it was determined that the mothers received infant care information more frequently from the healthcare organisation

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To Dye or Not to Dye: A Randomized, Clinical Trial of a Triple Dye/Alcohol Regime Versus Dry Cord Care

Abstract: Omphalitis remains a clinical issue. Cessation of bacteriocidal care of the umbilical stump must be accompanied by vigilant attention to the signs and symptoms of omphalitis.

Cited by 94 publications

References 12 publications

Modular video endoscopy forin vivocross-polarized and vital-dye fluorescence imaging of Barrett’s-associated neoplasia

Modular video endoscopy forin vivocross-polarized and vital-dye fluorescence imaging of Barrett’s-associated neoplasia

Role of antimicrobial applications to the umbilical cord in neonates to prevent bacterial colonization and infection: a review of the evidence

Evaluation of the Knowledge and Attitude Changes of Mothers in Neonatal Care

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