To compare the levels of salivary Interleukin 6 between oral potentially malignant disorders and oral squamous cell carcinoma

Abstract

To compare the levels of salivary Interleukin 6 between oral potentially malignant disorders and oral squamous cell carcinoma. After ethical clearance and informed consent, the saliva samples were collected from 20 patients of OPMD’S, 20 patients of OSCC and 10 controls. Salivary IL-6 levels were detected by enzyme linked Immunosorbent essay and appropriate statistical analysis was done. Significant differences in IL-6 concentration between OSCC, OPMD’S and controls were noted. Salivary IL-6 levels were higher in OSCC. The results of present study concluded that the level of salivary IL-6 in OSCC is significantly higher than oral potentially malignant disorders like OSMF and oral epithelial dysplasia and controls. This biomarker can be utilized as a major asset for early detection of cancer and can open a new horizon for treatment plans of targeted therapy.

Evaluation of Salivary Interleukin-6 in Patients with Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorders, Chronic Periodontitis and in Healthy Controls - A Cross-Sectional Comparative Study

“…Analogous with our study, a recent study done by Harshy et al . in 2022,[ 22 ] in comparing the levels of salivary IL-6 between 20 cases of OPMDs and OSCCs suggested that salivary IL-6 was statistically significant. In our study, there was statistical significance when comparing the salivary IL-6 between OSCC, OPMDs and CP and healthy controls which was not in accordance with the study done by St John et al .,[ 23 ] that indicated that IL-8 in saliva and IL-6 in serum hold the most promise as biomarkers for OSCC.…”