To compare the expression of p53 with hormonal receptor status in breast carcinoma: An immunohistochemical study

Abstract

Background: Breast carcinoma is the most common malignancy in women in the world. This study evaluated the expression of ER, PR and p53 in breast carcinoma and its correlation with age, size, lymph node status and other parameters. Methods: 103 histologically proven Breast carcinoma cases were subjected to IHC for ER,PR and p53. Result: Total cases of breast cancer were 103. All the cases were between 21-60 years with tumour size varying from 0.5->5cm. Maximum cases were of grade III. Metastatic carcinomatous deposits in lymph nodes were seen in 53 cases. Tumors were separated into 4 categories depending on ER/PR expression with ER-ve/PR-ve category having maximum number of cases. As the tumour grade increased lesser was the ER PR expression. P53 positivity was noted in 60 cases comprising of 58.3%. Significant correlation was noted while comparing p53 with lympho vascular invasion (p=0.042) but not with age, tumour size, tumour grade and lymph node status. Significant correlation was also noted while correlating p53 and ER/PR expression with tumour size (p = 0.036) but not with tumour grade, lympho vascular invasion and lymph node status. Conclusion:In the present study it was observed that ER PR status is inversely proportional to p53 expression. It is concluded that p53 has direct relationship with tumour grade, tumour size, lymphovascular invasion. Thus p53 helps to provide prognostic information and better treatment options