TO COMPARE EFFICACY OF METFORMIN VERSUS INSULIN IN IMPROVING GLYCAEMIC CONTROL OF MATERNAL & PERINATAL OUTCOME IN GESTATIONAL DIABETES MELLITUS PATIENTS

Abstract

Background: Diabetes Mellitus is a great burden to society. According to ACOG, gestational diabetes mellitus is dened as, any degree of glucose intolerance that either commences, or is rst diagnosed in pregnancy Gestational diabetes mellitus pose many risks to the mother and the fetus and its consequences lead to increased maternal and fetal morbidity. Maternal complications includes increased risk of developing pre-eclampsia, preterm labour, chorioamnionitis,etc. The Fetal and Neonatal risks include Growth abnormalities like Macrosomia, Growth Restriction etc. Not enough studies are available to know the efcacy of Metformin. Our aim in this study was to compare efcacy of Metformin with Insulin. Methods: An interventional study of all women with GDM whose pregnancy was followed in the Department of Obstetrics and Gynaecology at Rohilkhand Medical College, Bareilly, U.P, India. Our study included 330 women diagnosed as Gestational Diabetes Mellitus who needed medical management for glycaemic control. Group A of 165 women were treated with Tab. Metformin 500 mg. Group B of 165 women were treated with subcutaneous Insulin. The baseline characteristics of both the groups were simi Results: lar with respect to age, enrolment, nulliparity etc. There was no signicant statistical difference (p value > 0.05) between the two groups in terms of maternal and perinatal outcomes with respect to indicators like complications, HbA1c, pre eclampsia, side effects, etc. Conclusion: In our study we conclude that both metformin and insulin were equally effective in achieving the glycemic control in GDM patients. Both groups were comparable in terms of incidence of maternal and neonatal outcomes and complications with no statistical signicant difference.