To Compare and Evaluate Laryngeal Changes in Patients with Dysphonia in Laryngopharyngeal Reflux (LPR) before and after Treatment with Proton Pump Inhibitors (PPI) and Prokinetic Drugs

Jain, Sharad; Gupta, Sarita; Ramalingam, W.V.B.S.

doi:10.1007/s12070-020-02323-9

Cited by 1 publication

(2 citation statements)

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“…Belafsky et al reported that RFS > 7 has a 95% predictive value for LPR 40 . Various studies have further reported RFS to correlate well with RSI in monitoring the response to anti‐reflux therapy 61–63 . In our study, 14 (58.3%) patients with LPR indicated by RFS also had GERD confirmed by 24‐h esophageal pH monitoring.…”

Section: Discussionsupporting

confidence: 65%

“…40 Various studies have further reported RFS to correlate well with RSI in monitoring the response to anti-reflux therapy. [61][62][63] In our study, 14 (58.3%) patients with LPR indicated by RFS also had GERD confirmed by 24-h esophageal pH monitoring. This supports the likelihood of LPR in post-irradiated patients with NPC, which has been under attention in the past.…”

Section: Discussionsupporting

confidence: 53%

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The prevalence of gastroesophageal reflux disease and laryngopharyngeal reflux in patients with dysphagia after radiotherapy for nasopharyngeal carcinoma

Ku,

Vlantis,

Hui

et al. 2024

Head & Neck

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BackgroundThe prevalence of gastroesophageal reflux disease (GERD) and laryngopharyngeal reflux (LPR) in post‐irradiated patients with nasopharyngeal carcinoma (NPC) is unknown.Materials and methodsIn a cross‐sectional study, 31 NPC and 12 control patients completed questionnaires for GERD/LPR before esophageal manometry and 24‐h pH monitoring. The DeMeester score and reflux finding score (RFS) were used to define GERD and LPR, respectively. Risk factors were identified.Results51.6% of NPC and 8.3% of control patients, and 77.4% of NPC and 33% of control patients, were GERD‐positive and LPR‐positive, respectively. The GERD/LPR questionnaire failed to identify either condition in patients with NPC. No parameter differences in esophageal manometry or pneumonia incidence were noted between GERD/LPR‐positive and GERD/LPR‐negative patients. Post radiotherapy duration, high BMI, lack of chemotherapy, and dysphagia were positive risk factors for GERD/LPR.ConclusionsA high prevalence of GERD/LPR in patients with post‐irradiated NPC exists, but reflux symptoms are inadequate for diagnosis.

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Section: Discussionsupporting

confidence: 65%